Von willebrand factor antigen in assessment of vasculitis in patients with connective tissue diseases
Tóm tắt
Von Willebrand factor antigen (vWF:Ag) is synthesized and secreted by endothelial cells. In the present study we tried to assess the relationship between plasma level of vWF:Ag and vascular damage in patients with vasculitis. The study was carried out on 59 patients with connective tissue diseases. Vasculitis was diagnosed by biopsies of the skin. The patients with vasculitis had a significantly elevated level of vWF: Ag; however, no significant correlation between the amount of plasma vWF:Ag and the degree of vasculitis was found. The obtained results show that the plasma level of vWF: Ag may reflect the presence of vascular, especially endothelial, damage in patients with connective tissue diseases.
Tài liệu tham khảo
Jaffe, E.A., Hoyer, L.W., Nachman, R.L. Synthesis of antihemophilic factor antigen by cultured endothelial cells. J Clin Invest 1973, 52, 2757–2764.
Tuddenham, E.G.D., Lazarchick, J., Hoyer, L.W. Synthesis and release of factor VIII by cultured human endothelial cells. Br J Haematol 1981, 47, 617–626.
Brinkhous, K.M., Sultzer, D.L., Reddick, R.L., Griggs, T.R. Elevated plasma von Willebrand factor levels as an index of acute endothelial injury: use of a hypotonic injury model in rats (abstract). Fed Proc 1980, 39, 630.
Echberg, M.R., Nilsson, I.K., Linell, F. Significance of increased factor VIII in early glomerulonephritis. Ann Intern Med 1976, 83, 337–341.
Ciompi, M.L., Marotta, G., Puccetti, L., Remorini, E., Petrini, G., Zuccotti, M., Vispi, M., Baicchi, U., Lacconi, P. Behaviour of von Willebrand factor antigen in follow-up of polymyalgia rheumatica/giant cell arteritis, Scand J Rheumatol 1988, 17, 491–495.
Nusinow, S.R., Federici, A.B., Zimmerman, T.S., Curd, J.G. Increased von Willebrand factor antigen in the plasma of patients with vasculitis. Arthritis Rheum 1984, 27, 1405–1410.
Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980, 23, 581–590.
Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N., Winchester, R.J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1271–1277.
Arnett, F.C., Edworthy, S.M., Bloch, D.A., McShane, D.J., Fries, J.F., Cooper, N.S., Healey, L.A., Kaplan, S.R., Liang, M.H., Luthra, H.S., Medsger, T.A. Jr., Mitchell, D.M., Neustadt, D.H., Pinals, R.S., Schaller, J.G., Sharp, J.T., Wilder, R.L., Hunder, G.G. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31, 315–324.
Laurell, C.B. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 1966, 15, 45–52.
Alexander, E.L., Moyer, C., Travlos, G.S., Roths, J.B., Murphy, E.D. Two histopathologic types of inflammatory vascular disease in MRL/Mp autoimmune mice. Model for human vasculitis connective tissue disease. Arthritis Rheum 1985, 28, 1146–1155.
Belch, J.J.F., Zoma, A.A., Richards, I.M., McLaughlin, K., Forbes, C.D., Sturrock, R.D. Vascular damage and factor-VIII-related antigen in the rheumatic diseases. Rheumatol Int 1987, 7, 107–112.
Lee, P., Norman, C.S., Sukenik, S., Alderdice, C.A. The clinical significance of coagulation abnormalities in systemic sclerosis (scleroderma). J Rheumatol 1985, 12, 514–517.
Kloczko, J., Bielawiec, M., Galar, M., Wojtukiewicz, M., Von Willebrand factor antigen as a marker of vascular injury in patients with essential hypertension. In: Biofluid Mechanics, Ed.: Liepsch, D.W., Springer-Verlag, Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona 1990, 155–158.
Corda, G., Alberti, M., Caocci, L., Putzow, G., Mannocci, P.M. An increased factor VIII antigen as an indicator of endothelial damage in measles. Thromb Res 1979, 14, 805–810.
Kalaheh, M., Osborn, K., LeRoy, E. Increased factor VIII von Willebrand's factor activity in scleroderma and in Raynaud's phenomena. Ann Intern Med 1981, 94, 482–484.
Cunningham, T.J., Medcalf, R.L., Mathews, J.D., Muxirden, K.D. Platelet releasing activity in sera of patients with rheumatoid vasculitis. Ann Rheum Dis 1986, 45, 15–20.
Colli, S., Maderna, P., Tremoli, E., Colombo, F., Canesi, B. Platelet function in rheumatoid arthritis. Scand J Rheumatol 1982, 11, 139–143.