Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 2 - Trang 182-191 - 2016
Virginia Boccardi1, Marta Baroni1, Francesca Mangialasche2, Patrizia Mecocci1
1Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
2Aging Research Center, Karolinska Institutet/Stockholm University, Stockholm, Sweden

Tóm tắt

AbstractIntroductionVitamin E family, composed by tocopherols and tocotrienols, is a group of compounds with neuroprotective properties. The exact role in the pathogenesis and the benefit of vitamin E as treatment for Alzheimer's disease (AD) are still under debate.MethodsA literature search in PubMed, Medline, and Cochrane databases has been carried out. All types of studies, from bench and animal models to clinical, were included.ResultsHigh plasma vitamin E levels are associated with better cognitive performance, even if clear evidence of their ability to prevent or delay cognitive decline in AD is still lacking. Each vitamin E form is functionally unique and shows specific biological functions. Tocotrienols seem to have superior antioxidant and anti‐inflammatory properties compared with tocopherols.DiscussionThe benefit of vitamin E as a treatment for AD is still under debate, mainly because of the inconsistent findings from observational studies and the methodological limitations of clinical trials.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 2

182-191

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