Vitamin E effect on controlled ovarian stimulation of unexplained infertile women

Springer Science and Business Media LLC - Tập 29 - Trang 325-328 - 2012
Nedim Cicek1, Ozlem Gun Eryilmaz1, Esma Sarikaya1, Cavidan Gulerman1, Yasemin Genc2
1Zekai Tahir Burak Women Education and Research Hospital, Obstetrics and Gynecology, Ankara, Turkey
2Department of Medical Statistics, Ankara University, Faculty of Medicine, Ankara, Turkey

Tóm tắt

To determine Vit E effect on the treatment outcomes of women with unexplained infertility undergoing controlled ovarian stimulation and intrauterine insemination (IUI). The study group (Group A, n = 53) underwent controlled ovarian stimulation with clomiphene citrate with Vit E administration, 400 IU/day p.o. while the control group (Group B, n = 50) underwent ovulation induction without Vit E. Treatment outcomes were compared between the groups. There were no significant differences between the two groups with respect to the demographic outcomes. The difference in endometrial thickness on the day of hCG administration was significant between the two groups (p = 0.001). The effect of receiving Vit E on the implantation and the ongoing pregnancy rates were assesed Odds Ratio (OR) and corresponding 95% Confidence Intervals (CI). Receiving Vit E was not significantly associated with the implantation and the ongoing pregnancy rates; OR = 1.22, 95% CI (0.44–3.4) and OR = 1.43, 95% CI (0.49–4.1), respectively. Vit E administration may improve the endometrial response in unexplained infertile women via the likely antioxidant and the anticoagulant effects. It may also modulate the antiestrogenic effect of clomiphene citrate and the problem of a thin endometrium in these cycles may be adjusted.

Tài liệu tham khảo

Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol. 2006;18:325–32.

Riley RC, Behrman HR. Oxygen radicals and reactive oxygen species in reproduction. Proc Soc Exp Biol Med. 1991;198:781–91.

Roselli M, Keller PJ, Dubey RK. Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum Reprod Update. 1998;4:3–24.

Sugino N, Karube-Harada A, Taketani T, et al. Withdrawl of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activationvia oxygen radicals in human endometrial stromal cells:potential relevance to mensturation. J Reprod Dev. 2004;50:215–25.

Palamanda JR, Kehrer JP. Involvement of vitamin E and protein thiols in the inhibition of microsomal lipid peroxidation by glutathione. Lipids. 1993;28(5):427–31.

Agarwal A, Sekhon LH. Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: ıs it justified? Indian J Urol. 2011;27(1):74–85.

Blot WJ, Li JY, Taylor PR, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence and disease-specific mortality in the general population. J Natl Canc Inst. 1993;85:1483–92.

Bouayed J, Bohn T. Exogenous antioxidants-double-edged swords in cellular redox state. Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev. 2010;3(4):228–37.

Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet. 1999;354:810–6.

Porter R, Whelan J. Biology of vitamin E. Ciba foundation symposium 101. Proceedings of a symposium on biology of vitamin E. London: Pitman; 1984. p. 1430–9.

WHO. World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization; 2010.

Lédée-Bataille N, Olivennes F, Lefaix JL, et al. Combined treatment by pentoxifylline and tocopherol for recipient women with a thin endometrium enrolled in an oocyte donation programme. Hum Reprod. 2002;17(5):1249–453.

Chandra A, Martinez GM, Mosher WD, Abma JC, Jones J. Fertility, family planning and reproductive health of U.S. women: data from the 2002 National Survey of Family Growth. Vital Health Stat. 2002;23(25):1–160.

Hull MG, Glazener CM, Kelly NJ, et al. Population study of causes, treatment and outcomes of infertility. Br Med J (Clin Res Ed). 1985;291:1693–7.

Letur-Konirsch H, Delanian S. Successful pregnancies after combined pentoxifylline-tocopherol treatment in women with premature ovarian failure who are resistant to hormone replacement therapy. Fertil Steril. 2003;79(2):430–41.

Paszkowski T, Traub AI, Robinson SY, McMaster D. Selenium dependant gluthatione peroxidase activity in human follicular fluid. Clin Chim Acta. 1995;236:173–80.

Tovar A, Ameho CK, Blumberg JB, et al. Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet. Nutr Metab (Lond). 2006;20(3):29.

Bromer JG, Aldad TS, Taylor HS. Defining the proliferative phase endometrial defect. Fertil Steril. 2009;91:698–704.

Siebert TI, Kruger TF, Lombard C. Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients. J Assist Reprod Genet. 2009;26(4):165–71.

Thông tin
Thông tin xuất bản

Springer Science and Business Media LLC

Tập 29

325-328

Thông tin tác giả