Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial

Steiner TJ, Stovner LJ, Vos T, Jensen R, Katsarava Z (2018) Migraine is first cause of disability in under 50s: will health politicians now take notice? J Headache Pain 19(1):17

Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A et al (2007) The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27(3):193–210

Vetvik KG, MacGregor EA (2017) Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol 16(1):76–87

Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia : an international journal of headache 38(1):1–211

Dodick DW (2018) A phase-by-phase review of migraine pathophysiology. Headache 58(Suppl 1):4–16

Waeber C, Moskowitz MA (2005) Migraine as an inflammatory disorder. Neurology 64(10 suppl 2):S9–S15

Peroutka SJ (2005) Neurogenic inflammation and migraine: implications for the therapeutics. Mol Interv 5(5):304–311

Bruno P, Carpino F, Carpino G, Zicari A (2007) An overview on immune system and migraine. Eur Rev Med Pharmacol Sci 11(4):245–248

Ramachandran R (2018) Neurogenic inflammation and its role in migraine. Semin Immunopathol 40(3):301–314

Pietrobon D (2005) Migraine: new molecular mechanisms. Neuroscientist 11(4):373–386

Ceylan M, Bayraktutan OF, Becel S, Atis O, Yalcin A, Kotan D (2016) Serum levels of pentraxin-3 and other inflammatory biomarkers in migraine: association with migraine characteristics. Cephalalgia 36(6):518–525

Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, Bakkers JT, Hofman PA, van Lew B, Middelkoop HA, van Buchem M, Ferrari MD, Kruit MC (2012) Structural brain changes in migraine. Jama 308(18):1889–1897

Sadeghi O, Nasiri M, Maghsoudi Z, Pahlavani N, Rezaie M, Askari G (2015) Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: a double-blind randomized clinical trial study in Iran. Iran J Neurol 14(2):74–80

Eren Y, Dirik E, Neselioglu S, Erel O (2015) Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study. Acta Neurol Belg 115(4):643–649

Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, Haghighi S, et al (2019) Vitamin D in migraine headache: a comprehensive review on literature. Neurol Sci

Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930

Anjum I, Jaffery SS, Fayyaz M, Samoo Z, Anjum S (2018) The Role of Vitamin D in Brain Health: A Mini Literature Review. Cureus 10(7):e2960-e

van Harten-Gerritsen AS, Balvers MG, Witkamp RF, Kampman E, van Duijnhoven FJ (2015) Vitamin D, Inflammation, and colorectal Cancer progression: a review of mechanistic studies and future directions for epidemiological studies. Cancer Epidemiol Biomark Prev 24(12):1820–1828

Helde-Frankling M, Bjorkhem-Bergman L (2017) Vitamin D in Pain Management. Int J Mol Sci 18(10):2170

Martin KR, Reid DM (2017) Is there role for vitamin D in the treatment of chronic pain? Ther Adv Musculoskelet Dis 9(6):131–135

Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M (2018) Serum vitamin D status in a Group of Migraine Patients Compared with Healthy Controls: a case-control study. Headache 58(10):1530–1540

Martami F, Razeghi Jahromi S, Togha M, Ghorbani Z, Seifishahpar M, Saidpour A (2018) The serum level of inflammatory markers in chronic and episodic migraine: a case-control study. Neurol Sci 39(10):1741–1749

Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L et al (2006) Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Headache: J Head Face Pain 46(2):200–207

Fidan I, Yuksel S, Ymir T, Irkec C, Aksakal FN (2006) The importance of cytokines, chemokines and nitric oxide in pathophysiology of migraine. J Neuroimmunol 171(1–2):184–188

Tietjen G, Khubchandani J, Khan A, Herial N (2010) Adiponectin and Inflammatory Cytokines in Young Women with Migraine

Yücel M, Kotan D, Çiftçi GG, Çiftçi I, Cikriklar H (2016) Serum levels of endocan, claudin-5 and cytokines in migraine. Eur Rev Med Pharmacol Sci 20(5):930–936

Uzar E, Evliyaoglu O, Yucel Y, Ugur Cevik M, Acar A, Guzel I et al (2011) Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine. Eur Rev Med Pharmacol Sci 15(10):1111–1116

Oliveira AB, Bachi ALL, Ribeiro RT, Mello MT, Tufik S, Peres MFP (2017) Unbalanced plasma TNF-α and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes. J Neuroimmunol 313:138–144

Jahromi SR, Abolhasani M, Ghorbani Z, Sadre-Jahani S, Alizadeh Z, Talebpour M et al (2017) Bariatric surgery promising in migraine control: a controlled trial on weight loss and its effect on migraine headache. Obes Surg:1–10

Mottaghi T, Askari G, Khorvash F, Maracy MR (2015) Effect of vitamin D supplementation on symptoms and C-reactive protein in migraine patients. J Res Med Sci 20(5):477–482

Gazerani P, Fuglsang R, Pedersen JG, Sorensen J, Kjeldsen JL, Yassin H et al (2019) A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine. Curr Med Res Opin 35(4):715–723

Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, Mittleman MA et al (2015) Simvastatin and vitamin D for migraine prevention: a randomized, controlled trial. Ann Neurol 78(6):970–981

Wang M (2013) Cortical spreading depression and calcitonin gene-related peptide: a brief review of current progress. Neuropeptides 47(6):463–466

Close LN, Eftekhari S, Wang M, Charles AC, Russo AFJC (2018) Cortical spreading depression as a site of origin for migraine: Role of CGRP 0333102418774299

(2015) Pathophysiology of Headaches From Molecule to Man. Paolo Martelletti RJ (ed). Springer, Cham

Vanmolkot F, De Hoon J (2007) Increased C-reactive protein in young adult patients with migraine. Cephalalgia 27(7):843–846

Kurth T, Ridker P, Buring J (2008) Migraine and biomarkers of cardiovascular disease in women. Cephalalgia 28(1):49–56

Hamed SA, Hamed EA, Eldin AME, Mahmoud NM (2010) Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis. J Stroke Cerebrovasc Dis 19(2):92–103

Tietjen GE, Khubchandani J (2015) Vascular biomarkers in migraine. Cephalalgia 35(2):95–117

Güzel I, Taşdemir N, Çelik Y (2013) Evaluation of serum transforming growth factor β1 and C-reactive protein levels in migraine patients. Neurol Neurochir Pol 47(4):357–362

Covelli V, Munno I, Pellegrino N, Altamura M, Decandia P, Marcuccio C, di Venere A, Jirillo E (1991) Are TNF-alpha and IL-1 beta relevant in the pathogenesis of migraine without aura? Acta Neurol 13(2):205–211

Perini F, D'andrea G, Galloni E, Pignatelli F, Billo G, Alba S et al (2005) Plasma cytokine levels in migraineurs and controls. Headache: J Head Face Pain 45(7):926–931

Malhotra R (2016) Understanding migraine: potential role of neurogenic inflammation. Ann Indian Acad Neurol 19(2):175–182

Olesen J (2008) The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. Pharmacol Ther 120(2):157–171

Al-Daghri NM, Bukhari I, Yakout SM, Sabico S, Khattak MNK, Aziz I et al (2018) Associations of serum nitric oxide with vitamin D and other metabolic factors in apparently healthy adolescents. Biomed Res Int 2018:1489132

Golden TN (2016) The role of inducible nitric oxide synthase in macrophage activation following acute lung injury

de Oliveira DL, Hirotsu C, Tufik S, Andersen ML (2017) The interfaces between vitamin D, sleep and pain. J Endocrinol 234(1):R23–R36

Linden J, Granasen G, Salzer J, Svenningsson A, Sundstrom P (2019) Inflammatory activity and vitamin D levels in an MS population treated with rituximab. Mult Scler J Exp Transl Clin 5(1):2055217319826598

Wang Y, Yang S, Zhou Q, Zhang H, Yi B (2019) Effects of vitamin D supplementation on renal function, inflammation and glycemic control in patients with diabetic nephropathy: a systematic review and meta-analysis. Kidney Blood Press Res 44(1):72–87

Filgueiras MS, Rocha NP, Novaes JF, Bressan J (2018) Vitamin D status, oxidative stress, and inflammation in children and adolescents: a systematic review. Crit Rev Food Sci Nutr 1–10

Chen N, Wan Z, Han SF, Li BY, Zhang ZL, Qin LQ (2014) Effect of vitamin D supplementation on the level of circulating high-sensitivity C-reactive protein: a meta-analysis of randomized controlled trials. Nutrients 6(6):2206–2216

Sepidarkish M, Farsi F, Akbari-Fakhrabadi M, Namazi N, Almasi-Hashiani A, Maleki Hagiagha A, Heshmati J (2019) The effect of vitamin D supplementation on oxidative stress parameters: a systematic review and meta-analysis of clinical trials. Pharmacol Res 139:141–152

Akbari M, Ostadmohammadi V, Lankarani KB, Tabrizi R, Kolahdooz F, Heydari ST et al (2018) The effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Horm Metab Res 50(4):271–279

Colotta F, Jansson B, Bonelli F (2017) Modulation of inflammatory and immune responses by vitamin D. J Autoimmun 85:78–97

Sarchielli P, Floridi A, Mancini M, Rossi C, Coppola F, Baldi A, Pini LA, Calabresi P (2006) NF-κB activity and iNOS expression in monocytes from internal jugular blood of migraine without Aura patients during attacks. Cephalalgia 26(9):1071–1079

Dursun E, Gezen-Ak D, Yilmazer S (2014) The influence of vitamin D treatment on the inducible nitric oxide synthase (INOS) expression in primary hippocampal neurons. Noro Psikiyatri Arsivi 51(2):163–168

Shipton EA, Shipton EE (2015) Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities. Pain Res Treat 2015:904967

Pradhan AA, Bertels Z, Akerman S (2018) Targeted nitric oxide synthase inhibitors for migraine. Neurotherapeutics 15(2):391–401

Andrukhova O, Slavic S, Zeitz U, Riesen SC, Heppelmann MS, Ambrisko TD et al (2014) Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol (Baltimore, Md) 28(1):53–64

Bikle D (2009) Nonclassic actions of vitamin D. J Clin Endocrinol Metab 94(1):26–34