Vitamin D receptor regulates TGF-β signalling in systemic sclerosis

Gabrielli, 2009, Scleroderma, N Engl J Med, 360, 1989, 10.1056/NEJMra0806188

Varga, 2007, Systemic sclerosis: a prototypic multisystem fibrotic disorder, J Clin Invest, 117, 557, 10.1172/JCI31139

Beyer, 2012, Innovative antifibrotic therapies in systemic sclerosis, Curr Opin Rheumatol, 24, 274, 10.1097/BOR.0b013e3283524b9a

Kowal-Bielecka, 2009, EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR), Ann Rheum Dis, 68, 620, 10.1136/ard.2008.096677

Haroon, 2012, Vitamin D and its emerging role in immunopathology, Clin Rheumatol, 31, 199, 10.1007/s10067-011-1880-5

Cutolo, 2013, Further emergent evidence for the vitamin D endocrine system involvement in autoimmune rheumatic disease risk and prognosis, Ann Rheum Dis, 72, 473, 10.1136/annrheumdis-2012-202538

Messa, 2011, Recent insights into vitamin D and its receptor, J Nephrol, 24, S30, 10.5301/JN.2011.7767

Yee, 2005, Vitamin D receptor modulators for inflammation and cancer, Mini Rev Med Chem, 5, 761, 10.2174/1389557054553785

Arnson, 2011, Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: a retrospective cohort study and review of the literature, Autoimmun Rev, 10, 490, 10.1016/j.autrev.2011.02.002

Belloli, 2011, Vitamin D in systemic sclerosis, Clin Rheumatol, 30, 145, 10.1007/s10067-010-1564-6

Calzolari, 2009, Hypovitaminosis D in systemic sclerosis, J Rheumatol, 36, 2844, 10.3899/jrheum.090439

Caramaschi, 2010, Very low levels of vitamin D in systemic sclerosis patients, Clin Rheumatol, 29, 1419, 10.1007/s10067-010-1478-3

Gambichler, 2011, Significantly decreased serum 25-hydroxyvitamin d levels in a large german systemic sclerosis cohort, J Rheumatol, 38, 2492, 10.3899/jrheum.110695

Rios Fernandez, 2010, Vitamin D deficiency in a cohort of patients with systemic scleroderma from the south of Spain, J Rheumatol, 37, 1355, 10.3899/jrheum.091143

Rios-Fernandez, 2012, Bone mass and vitamin D in patients with systemic sclerosis from two Spanish regions, Clin Exp Rheumatol, 30, 905

Vacca, 2009, Vitamin D deficiency and insufficiency in 2 independent cohorts of patients with systemic sclerosis, J Rheumatol, 36, 1924, 10.3899/jrheum.081287

Szyszka, 2012, New vitamin D analogs as potential therapeutics in melanoma, Expert Rev Anticancer Ther, 12, 585, 10.1586/era.12.40

Slatopolsky, 1999, New analogs of vitamin D3, Kidney Int Suppl, 73, S46, 10.1046/j.1523-1755.1999.07305.x

Sprague, 2003, Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism, Kidney Int, 63, 1483, 10.1046/j.1523-1755.2003.00878.x

Akhmetshina, 2008, Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts, Arthritis Rheum, 58, 2553, 10.1002/art.23677

Kronke, 2012, The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis, Ann Rheum Dis, 71, 1081, 10.1136/annrheumdis-2011-200745

Akhmetshina, 2010, Decreased lymphatic vessel counts in patients with systemic sclerosis: association with fingertip ulcers, Arthritis Rheum, 62, 1513, 10.1002/art.27406

Beyer, 2012, beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis, Ann Rheum Dis, 71, 761, 10.1136/annrheumdis-2011-200568

Dees, 2011, Platelet-derived serotonin links vascular disease and tissue fibrosis, J Exp Med, 208, 961, 10.1084/jem.20101629

Horn, 2012, Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis, Arthritis Rheum, 64, 2724, 10.1002/art.34444

Akhmetshina, 2012, Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis, Nat Commun, 3, 735, 10.1038/ncomms1734

Dees, 2012, JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor beta in systemic sclerosis, Arthritis Rheum, 64, 3006, 10.1002/art.34500

Dees, 2013, The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis, Ann Rheum Dis

Zerr, 2012, Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease, Blood, 120, 2909, 10.1182/blood-2012-01-403428

Beyer, 2012, Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis, Ann Rheum Dis, 71, 1019, 10.1136/annrheumdis-2011-200862

Dees, 2011, Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis, Ann Rheum Dis, 70, 1304, 10.1136/ard.2010.134742

Palumbo, 2011, The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis, Ann Rheum Dis, 70, 1320, 10.1136/ard.2010.148296

Li, 1997, Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia, Proc Natl Acad Sci USA, 94, 9831, 10.1073/pnas.94.18.9831

Beyer, 2013, Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis, Ann Rheum Dis, 72, 1255, 10.1136/annrheumdis-2012-202544

Beyer, 2013, Activation of pregnane X receptor inhibits experimental dermal fibrosis, Ann Rheum Dis, 72, 621, 10.1136/annrheumdis-2012-202476

Tomcik, 2013, Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-beta signalling to prevent fibrosis, Ann Rheum Dis, 10.1136/annrheumdis-2013-eular.585

Khodzhigorova, 2012, Inhibition of sumoylation prevents experimental fibrosis, Ann Rheum Dis, 71, 1904, 10.1136/annrheumdis-2012-201746

Bergmann, 2011, Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway, Ann Rheum Dis, 70, 2191, 10.1136/ard.2010.147140

Marquart, 2010, Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis, Arthritis Rheum, 62, 3467, 10.1002/art.27642

Reich, 2012, Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis, Ann Rheum Dis, 71, 737, 10.1136/annrheumdis-2011-200412

Kramer, 2013, Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis, Ann Rheum Dis, 72, 614, 10.1136/annrheumdis-2012-201615

Weingartner, 2012, Pomalidomide is effective for prevention and treatment of experimental skin fibrosis, Ann Rheum Dis, 71, 1895, 10.1136/annrheumdis-2012-201784

LeRoy, 1974, Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast, J Clin Invest, 54, 880, 10.1172/JCI107827

Avouac, 2012, Increased risk of osteoporosis and fracture in women with systemic sclerosis: a comparative study with rheumatoid arthritis, Arthritis Care Res (Hoboken), 64, 1871, 10.1002/acr.21761

Shinjo, 2011, Low bone mass in juvenile onset sclerosis systemic: the possible role for 25-hydroxyvitamin D insufficiency, Rheumatol Int, 31, 1075, 10.1007/s00296-010-1421-6

Beyer, 2010, Animal models of systemic sclerosis: prospects and limitations, Arthritis Rheum, 62, 2831, 10.1002/art.27647

Ito, 2013, A nonclassical vitamin D receptor pathway suppresses renal fibrosis, J Clin Invest, 123, 4579, 10.1172/JCI67804

Xiong, 2012, Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition, Am J Physiol Renal Physiol, 303, F1107, 10.1152/ajprenal.00151.2012

Zhang, 2010, Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system, J Am Soc Nephrol, 21, 966, 10.1681/ASN.2009080872

Ding, 2013, A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response, Cell, 153, 601, 10.1016/j.cell.2013.03.028

Slominski, 2013, 20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo, J Clin Endocrinol Metab, 98, E298, 10.1210/jc.2012-3074