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Thiếu Vitamin D Tăng Thêm Rủi Ro Do Kháng Insulin Trong Các Khối U Kết Trực Tràng
Tóm tắt
Cả kháng insulin (IR) và thiếu vitamin D (VitDdef) đều được xem xét là các yếu tố nguy cơ đối với các khối u kết trực tràng (CRNs). Tuy nhiên, mối liên hệ giữa hai yếu tố này đối với CRNs còn chưa rõ ràng. Nghiên cứu nhằm xác định xem IR có phải là yếu tố nguy cơ cho CRNs hay không và liệu VitDdef có tạo ra rủi ro bổ sung cho CRNs hay không. Chúng tôi đã phân tích những phụ nữ không có triệu chứng và chưa từng nội soi đại tràng tham gia chương trình sàng lọc sức khỏe định kỳ. IR được định nghĩa là chỉ số đánh giá mô hình homeostatic về IR >3 và VitDdef được đặt là <20 ng/mL. Phân tích hồi quy logistic đa biến đã được thực hiện giữa những phụ nữ có và không có CRNs, được ghép cặp theo độ tuổi và chỉ số khối cơ thể, để điều tra mối liên hệ với CRNs trong IR, VitDdef và VitDdef kết hợp với IR. Chúng tôi đã phân tích 216 phụ nữ có CRNs và 216 phụ nữ không có CRNs. Một mối liên hệ đáng kể đã được tìm thấy giữa IR và CRNs (OR 1.838, 95 % CI 1.029–3.285, P = 0.040) nhưng không với VitDdef. IR tạo ra rủi ro cao hơn ở các CRNs giai đoạn tiến triển (OR 3.244, 95 % CI 1.588–6.631, P = 0.001) so với CRNs. Khi VitDdef được kết hợp với IR, rủi ro của cả CRNs và CRNs giai đoạn tiến triển đều tăng lên (OR 2.131, 95 % CI 1.077–4.216, P = 0.030 và OR 4.438, 95 % CI 2.058–9.571, P < 0.001, tương ứng). IR làm tăng nguy cơ mắc CRNs, và sự kết hợp của IR và VitDdef càng làm tăng thêm nguy cơ này. Vì cả VitDdef và IR đều là các yếu tố nguy cơ có thể điều chỉnh, những mối liên hệ như vậy có thể có ý nghĩa lâm sàng quan trọng trong phòng ngừa CRNs.
Từ khóa
#kháng insulin #thiếu vitamin D #khối u kết trực tràng #yếu tố nguy cơ #sức khỏe phụ nữTài liệu tham khảo
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