Visceral adipose tissue area is an independent risk factor for hepatic steatosis

Journal of Gastroenterology and Hepatology (Australia) - Tập 23 Số 6 - Trang 900-907 - 2008
Byung‐Joo Park1, Yoon Jun Kim2, Donghee Kim2, Won Kim2, Yeon-Ji Jung2, Jung‐Hwan Yoon2, Chung Y. Kim2, Young M. Cho3, Se H Kim4, Kyoung Bun Lee5, Ja June Jang5, Hyo S. Lee2
1Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
2Department of Internal Medicine and Liver Research Institute
3Division of Endocrinology and Metabolism
4Department of Radiology
5Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

Tóm tắt

AbstractBackground and Aim: Recent data indicate that hepatic steatosis is associated with insulin resistance, dyslipidemia and obesity (especially central body fat distribution). There have been few studies on the correlation between biopsy‐proven hepatic steatosis and the above factors in a disease‐free population. The aim of the present study was to evaluate the relation between hepatic steatosis assessed by biopsy and clinical characteristics including regional fat distribution measured by computed tomography (CT) in living liver donors.Methods: Laboratory data, liver/spleen Hounsfield ratio (L/S ratio), regional fat distribution by CT and liver status by biopsy were evaluated retrospectively in a total of 177 living liver donors without a history of alcohol intake.Results: The unpairedt‐test showed that age, triglycerides (TG), high density lipoprotein, total cholesterol, alanine aminotransferase, body mass index, L/S ratio, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) were associated with hepatic steatosis. In the multiple logistic regression analysis, VAT (odds ratio 1.031, 95% CI 1.013–1.048,P < 0.01) and TG (odds ratio 1.012, 95% CI 1.004–1.020,P < 0.01) were independent risk factors of hepatic steatosis. Subgroup analysis also showed that VAT was an independent risk factor in men (odds ratio 1.022, 95% CI 1.003–1.041,P < 0.05) and women (odds ratio 1.086, 95% CI 1.010–1.168,P < 0.05).Conclusion: Our results suggest that visceral abdominal adiposity is correlated with hepatic steatosis in healthy living liver donors.

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Thông tin xuất bản

Journal of Gastroenterology and Hepatology (Australia)

Tập 23 Số 6

900-907

Thông tin tác giả