Visceral Fat Accumulation and Its Relation to Plasma Hemostatic Factors in Healthy Men

Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 16 Số 3 - Trang 368-374 - 1996
M. Cigolini1, Giovanni Targher1, I. A. Bergamo Andreis1, M. Tonoli1, G. Agostino1, G. De Sandre1
1From the Institute of Clinical Medicine (M.C., M.T., G.A., G. De S.), the Department of Metabolic Diseases (G.T.), and the Institute of Radiology (I.A.B.A.), University of Verona, Verona, Italy.

Tóm tắt

Abstract The associations between abdominal visceral fat and the plasma hemostatic system were examined in 38-year-old healthy men (n=52) with a wide range of fatness and fat distribution. Plasma hemostatic factors and metabolic parameters, including glucose tolerance, were measured, and body fatness and adipose tissue distribution were assessed by using computed tomography. The men with more visceral fat (ie, higher than the median value [n=26]) had a less favorable metabolic profile than the men with less visceral fat (n=26). They also had significantly ( P <.05) higher plasma fibrinogen, factor VIII clotting activity, tissue-type plasminogen activator antigen, and plasminogen activator inhibitor–1 (PAI-1) activity (19.2±2.4 versus 8.5±1.6 AU/mL, P <.001) and lower basal tissue-type plasminogen activator activity. After adjustment for plasma insulin, the men with larger abdominal visceral fat area still had significantly higher plasma PAI-1 activity, but no difference was found in any of the other hemostatic factors. In multiple linear regression analysis, abdominal visceral fat area was a positive predictor of plasma PAI-1 activity, but it failed to show any significant association with other hemostatic factors after controlling for plasma insulin. These results suggest the presence of relationships between abdominal visceral fat and several plasma hemostatic factors that are largely mediated by concomitant alterations in plasma insulin concentration. In addition, our results suggest that abdominal accumulation of visceral fat is an independent predictor of plasma PAI-1 activity.

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Tài liệu tham khảo

10.1152/physrev.1994.74.4.761

10.1016/0049-3848(93)90221-9

10.1016/0140-6736(93)92062-X

10.1001/jama.1987.03400090067035

10.1161/atv91.14.1.8274478

10.1056/NEJM199503093321003

10.1136/hrt.66.5.351

10.1016/0021-9150(91)90167-2

10.1007/BF00403280

10.1016/0021-9150(92)90014-8

10.1016/0021-9150(94)90119-8

10.1111/j.1365-2362.1994.tb00977.x

10.1055/s-0038-1649589

10.1016/0026-0495(90)90164-8

10.1016/0026-0495(89)90241-2

10.1016/0895-4356(89)90067-X

10.1016/0895-4356(94)90298-4

10.1016/0268-9499(89)90028-3

10.1161/atv91.13.2.8427853

1993, Int J Obes, 17, 187

1986, Am J Physiol, 250, E736

1995, Int J Obes, 19, 92

World Health Organization. Diabetes mellitus: report of a WHO study group. Geneva Switzerland: World Health Organization; 1985. Technical report series 727.

10.1016/0049-3848(88)90029-1

10.1161/circ.88.5.8222095

10.1016/0140-6736(93)90998-V

10.1055/s-0038-1645996

10.1093/oxfordjournals.eurheartj.a059745

10.1097/00041433-199410000-00011

10.1016/0026-0495(94)90020-5

1993, Nutr Metab Cardiovasc Dis, 3, 165

10.1161/atv91.13.12.8241109

10.1161/atv91.14.8.8049187

10.1007/BF00400356

10.1161/01.ATV.10.6.1067

10.1161/atv91.12.1.1310024

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Thông tin xuất bản

Arteriosclerosis, Thrombosis, and Vascular Biology

Tập 16 Số 3

368-374

Thông tin tác giả