Virus interference. I. The interferon

The Royal Society - Tập 147 Số 927 - Trang 258-267 - 1957
A. Isaacs1, J. Lindenmann1
1National Institute for Medical Research, London

Tóm tắt

During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after 3 h incubation and thereafter it was released into the surrounding fluid.

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