Vinorelbine-related acute cardiopulmonary toxicity

Cancer Chemotherapy and Pharmacology - Tập 43 - Trang 180-182 - 1999
Nataly Karminsky1, Ofer Merimsky1, Fleix Kovner1, Moshe Inbar1
1Department of Oncology, The Tel-Aviv Sourasky Medical Center, Tel-Aviv, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel, , IL

Tóm tắt

Three cases of possible acute cardiopulmonary toxicity following the administration of vinorelbine are reported. The symptoms mimicked acute cardiac ischemia. However, neither ECG changes nor elevations of serum enzymes were observed. The outcome is favorable in 90% of patients developing this adverse event. The putative mechanism remains to be elucidated.