Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala

American Association for the Advancement of Science (AAAS) - Tập 308 Số 5719 - Trang 245-248 - 2005
Daniel Huber1,2, Pierre Veinante1,2, Ron Stoop1,2
1Department of Cellular Biology and Morphology and Centre for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.
2Neurophysiologie Cellulaire et Intégrée, Unité Mixte de Recherche 7519, CNRS, Université Louis Pasteur, Strasbourg, France.

Tóm tắt

Vasopressin and oxytocin strongly modulate autonomic fear responses, through mechanisms that are still unclear. We describe how these neuropeptides excite distinct neuronal populations in the central amygdala, which provides the major output of the amygdaloid complex to the autonomic nervous system. We identified these two neuronal populations as part of an inhibitory network, through which vasopressin and oxytocin modulate the integration of excitatory information from the basolateral amygdala and cerebral cortex in opposite manners. Through this network, the expression and endogenous activation of vasopressin and oxytocin receptors may regulate the autonomic expression of fear.

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We thank M. Raggenbass for introducing us to the exciting world of neuropeptides and F. Magara E. Welker M.-C. Broillet and P. Magistretti for critical reading and comments to the manuscript. Supported by grants from the Swiss National Science Foundation the Roche Research Foundation and the Novartis and Théodore Ott Foundations.

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American Association for the Advancement of Science (AAAS)

Tập 308 Số 5719

245-248

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