Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 789-796 - 2019
Jordan T. Gladman1, Roderick A. Corriveau1, Stephanie Debette2,3, Martin Dichgans4,5,6, Steven M. Greenberg, Perminder S. Sachdev7, Joanna M. Wardlaw8, Geert Jan Biessels9
1Department of Neuroscience, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
2University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, Bordeaux, France
3Department of Neurology, University Hospital of Bordeaux, Bordeaux, France
4Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany
5German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany
6Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
7Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia
8Centre for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Little France, Edinburgh
9Department of Neurology, G03.232, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands

Tóm tắt

AbstractThe research into vascular contributions to cognitive impairment and dementia (VCID) aims to understand the importance of cerebrovascular biology in cognitive decline. Prevention and treatment of VCID is poised to have major impact on dementia‐related disease burden and is thus a critical emerging objective in dementia research. This article presents VCID consortia focused on multidisciplinary approaches to identify key pathologic targets and develop diagnostic tools with the goal of bridging the divide between basic research and clinical trials. Members of these multi‐institute, multidisciplinary consortia provide a prospective on the history and emerging science of VCID and how VCID consortia can address some of the more complex questions in VCID and drive the field forward. These consortia, and others like them, are uniquely suited to tackle some of the most difficult obstacles in translating research to the clinic.

Tài liệu tham khảo

10.1016/j.jalz.2014.10.008 10.1007/s10571-016-0334-7 10.1038/nrdp.2018.3 10.1007/s00401-017-1717-7 10.1212/WNL.0000000000004717 10.1016/j.jalz.2015.12.007 10.1001/jama.2018.21442 10.1016/S0140-6736(15)60461-5 10.1016/j.jamda.2017.09.020 10.1016/j.dadm.2019.01.002 10.1161/01.STR.0000237236.88823.47 10.1212/WNL.43.2.250 10.1212/01.wnl.0000341271.90478.8e 10.1161/STR.0b013e3182299496 10.1016/j.jalz.2018.02.018 10.1038/nrclinonc.2016.162 10.1038/nrneph.2013.108 10.1016/j.jalz.2018.07.222 10.1016/j.dadm.2016.10.006 10.1002/ana.24621 10.1016/S1474-4422(16)00102-2 10.1161/STROKEAHA.117.018922 NINDS, 2017, NIH Consortium Takes Aim at Vascular Disease‐Linked Cognitive Impairment and Dementia 10.1161/STROKEAHA.117.017246 10.1093/cvr/cvy113 NIH, 2019, Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC) 10.1016/j.jalz.2013.12.013 10.1016/j.jalz.2016.06.004
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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 5

789-796

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