Variability in the Human Entorhinal Region May Confound Neuropsychiatric Diagnoses

Cells Tissues Organs - Tập 157 Số 3 - Trang 226-237 - 1996
Helmut Heinsen1, E. Gössmann1, U. Rüb2, Wolfgang Eisenmenger3, Mark A. Bauer4, G. Ulmar4, B. Bethke5, Michael Schüler6, Holger Schmitt7, M. Götz8, U. Lockemann9, Klaus Püschel9
1Morphologische Hirnforschung, Universitäts-Nervenklinik, Würzburg,
2ervenkrankenhaus des Bezirks Unterfranken, Lohr,
3Institut für Rechtsmedizin der Universität, München,
4Psychiatrisches Landeskrankenhaus, Wiesloch,
5Institut für Pathologie, Klinikum Bayreuth
6Nervenkrankenhaus des Bezirks Oberfranken, Bayreuth,
7Institut für Neuropathologie, Heidelberg,
8Institut für Pathologie, Klinikum Aschaffenburg,
9Institut für Rechtsmedizin, Hamburg, Germany

Tóm tắt

The human entorhinal region consists of a number of areas; however, there is no generally accepted nomenclature for these cytoarchitectonic fields, and the designation of its constituent layers or strata is a matter of controversy. Here, we consider a hitherto neglected adjacent field, the preamygdaloid claustrocortex. Its medial subfield has a small common border with the rostromedial entorhinal region (width maximal 2 mm). Both fields are cytoarchitectonically rather similar. The rostromedial oral entorhinal field lacks ascending terminal islands. Its unusually small pre-alpha cells are arranged in a thin band or small clusters consisting of pyramidal, triangular, or polymorphic cells. The conspicuous chromophilic pre-beta cell clusters are composed of a variety of cell types, including groups of ‘immature’ spindle-shaped or bipolar nerve cells. Furthermore, a rare sulcus within the entorhinal region (central sulcus of the entorhinal region: observed in 4% of the 450 brains examined) is associated with an unusual lamination of the entorhinal layers in its wall and floor. Both the specific shape and arrangement of neurones in the claustrocortical-rostral entorhinal border region and the unusual lamination within the rare central entorhinal sulcus are regarded as reflecting neurodevelopmental disturbances characteristic of schizophrenic brains. In contrast, our observations in a large sample of serially sectioned brains from controls, schizophrenics, and patients suffering from neuropsychiatric diseases other than schizophrenia do not support this assumption.

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Cells Tissues Organs

Tập 157 Số 3

226-237

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