The Dynamic in vivo Distribution of Bone Marrow-Derived Mesenchymal Stem Cells after Infusion Tập 169 Số 1 - Trang 12-20 - 2001
Jizong Gao, James E. Dennis, Raymond F. Muzic, Magnus Lundberg, Arnold I. Caplan
Bone marrow-derived mesenchymal stem cells (MSCs) have the potential to
differentiate along different mesenchymal lineages including those forming bone,
cartilage, tendon, fat, muscle and marrow stroma that supports hematopoiesis.
This differentiation potential makes MSCs candidates for cell-based therapeutic
strategies for mesenchymal tissue injuries and for hematopoietic disorders by
both local ... hiện toàn bộ
Vimentin and Epithelial-Mesenchymal Transition in Human Breast Cancer – Observations in vitro and in vivo Tập 185 Số 1-3 - Trang 191-203 - 2007
Maria I. Kokkinos, Razan Wafai, M. K. Wong, Donald F. Newgreen, Erik W. Thompson, Mark Waltham
Breast cancer is a highly prevalent disease among women worldwide. While the
expression of certain proteins within these tumours is used for prognosis and
selection of therapies, there is a continuing need for additional markers to be
identified. A considerable amount of current literature, based predominantly on
cell culture systems, suggests that a major mechanism responsible for the
progression... hiện toàn bộ
The Origin, Formation and Developmental Significance of the Epicardium: A Review Tập 169 Số 2 - Trang 89-103 - 2001
Jörg Männer, José M. Pérez‐Pomares, David Macías, Ramón Muñoz‐Chápuli
Questions on the embryonic origin and developmental significance of the
epicardium did not receive much recognition for more than a century. It was
generally thought that the epicardium was derived from the outermost layer of
the primitive myocardium of the early embryonic heart tube. During the past few
years, however, there has been an increasing interest in the development of the
epicardium. Th... hiện toàn bộ
Impaired Intramembranous Bone Formation during Bone Repair in the Absence of Tumor Necrosis Factor-Alpha Signaling Tập 169 Số 3 - Trang 285-294 - 2001
Louis C. Gerstenfeld, T. J. Cho, Tamiyo Kon, Toshimi Aizawa, J. Cruceta, Bruce Graves, Thomas A. Einhorn
Tumor necrosis factor-alpha (TNF-α) is known to mediate bone resorption;
however, its role in osteogenesis has not been fully elucidated. In order to
investigate the direct role of TNF-α signaling in the recruitment and
differentiation of osteoblasts, two separate models of bone repair were used,
marrow ablation and simple transverse fractures. These models were carried out
in the tibiae of both w... hiện toàn bộ
Influence of Platelet-Rich Plasma on Chondrogenic Differentiation and Proliferation of Chondrocytes and Mesenchymal Stem Cells Tập 189 Số 5 - Trang 317-326 - 2009
Anja Drengk, Antonia Zapf, Ewa K. Stürmer, K. M. Stürmer, Karl‐Heinz Frosch
Background/Aims: Autologous chondrocyte (CC) transplantation has the
disadvantages of requiring two surgical interventions and in vitro expansion of
cells, implying the risk of cellular dedifferentiation. Our clinical aim is to
develop a one-step procedure for autologous CC transplantation, i.e. harvesting,
isolation and reimplantation of CC performed in one single surgical procedure.
Plate... hiện toàn bộ
Effects of Ovarian Steroids on Vaginal Smears in the Rat Tập 133 Số 3 - Trang 192-199 - 1988
G.S. Monies, Enrique H. Luque
A correspondence between the appearance of vaginal smears and the layers of the
epithelium from which the cells had desquamated was established in untreated
rats during the estrous cycle, in control ovariectomized rats and in spayed rats
injected with either estrogen or progesterone. The technique for preparing and
staining the smears (modified Shorr’s staining procedure) is outlined. A
simplified... hiện toàn bộ
Pathophysiological Mechanisms in Osteoarthritis Lead to Novel Therapeutic Strategies Tập 174 Số 1-2 - Trang 34-48 - 2003
Charles J. Malemud, Najmul Islam, Tariq M. Haqqi
Osteoarthritis (OA) is a debilitating, progressive disease of diarthrodial
joints associated with aging. At the molecular level, OA is characterized by an
imbalance between anabolic (i.e. extracellular matrix biosynthesis) and
catabolic (i.e. extracellular matrix degradation) pathways in which articular
cartilage is the principal site of tissue injury responses. The pathophysiology
of OA also invo... hiện toàn bộ
Secreted Proteins of the Oviduct Tập 166 Số 2 - Trang 165-179 - 2000
W.C. Buhi, Idania M. Alvarez, Andrew J. Kouba
During late follicular development and estrus, the mammalian oviduct undergoes
specific physiological and biochemical modifications which contribute to an
optimization of the microenvironment for fertilization and early cleavage-stage
embryonic development. These changes appear to be hormonally regulated by
ovarian steroids, most importantly, estrogen. The hundreds of macromolecules
found within t... hiện toàn bộ