The Dynamic in vivo Distribution of Bone Marrow-Derived Mesenchymal Stem Cells after Infusion Tập 169 Số 1 - Trang 12-20 - 2001
Jizong Gao, James E. Dennis, Raymond F. Muzic, Magnus Lundberg, Arnold I. Caplan
Bone marrow-derived mesenchymal stem cells (MSCs) have the potential to differentiate along different mesenchymal lineages including those forming bone, cartilage, tendon, fat, muscle and marrow stroma that supports hematopoiesis. This differentiation potential makes MSCs candidates for cell-based therapeutic strategies for mesenchymal tissue injuries and for hematopoietic disorders by bot...... hiện toàn bộ Vimentin and Epithelial-Mesenchymal Transition in Human Breast Cancer – Observations in vitro and in vivo Tập 185 Số 1-3 - Trang 191-203 - 2007
Maria I. Kokkinos, Razan Wafai, M. K. Wong, Donald F. Newgreen, Erik W. Thompson, Mark Waltham
Breast cancer is a highly prevalent disease among women worldwide. While the expression of certain proteins within these tumours is used for prognosis and selection of therapies, there is a continuing need for additional markers to be identified. A considerable amount of current literature, based predominantly on cell culture systems, suggests that a major mechanism responsible for the pro...... hiện toàn bộ The Origin, Formation and Developmental Significance of the Epicardium: A Review Tập 169 Số 2 - Trang 89-103 - 2001
Jörg Männer, José M. Pérez‐Pomares, David Macías, Ramón Muñoz‐Chápuli
Questions on the embryonic origin and developmental significance of the epicardium did not receive much recognition for more than a century. It was generally thought that the epicardium was derived from the outermost layer of the primitive myocardium of the early embryonic heart tube. During the past few years, however, there has been an increasing interest in the development of the epicar...... hiện toàn bộ Impaired Intramembranous Bone Formation during Bone Repair in the Absence of Tumor Necrosis Factor-Alpha Signaling Tập 169 Số 3 - Trang 285-294 - 2001
Louis C. Gerstenfeld, T. J. Cho, Tamiyo Kon, Toshimi Aizawa, J. Cruceta, Bruce Graves, Thomas A. Einhorn
Tumor necrosis factor-alpha (TNF-α) is known to mediate bone resorption; however, its role in osteogenesis has not been fully elucidated. In order to investigate the direct role of TNF-α signaling in the recruitment and differentiation of osteoblasts, two separate models of bone repair were used, marrow ablation and simple transverse fractures. These models were carried out in the tibiae o...... hiện toàn bộ Effects of Ovarian Steroids on Vaginal Smears in the Rat Tập 133 Số 3 - Trang 192-199 - 1988
G.S. Monies, Enrique H. Luque
A correspondence between the appearance of vaginal smears and the layers of the epithelium from which the cells had desquamated was established in untreated rats during the estrous cycle, in control ovariectomized rats and in spayed rats injected with either estrogen or progesterone. The technique for preparing and staining the smears (modified Shorr’s staining procedure) is outlined. A si...... hiện toàn bộ Pathophysiological Mechanisms in Osteoarthritis Lead to Novel Therapeutic Strategies Tập 174 Số 1-2 - Trang 34-48 - 2003
Charles J. Malemud, Najmul Islam, Tariq M. Haqqi
Osteoarthritis (OA) is a debilitating, progressive disease of diarthrodial joints associated with aging. At the molecular level, OA is characterized by an imbalance between anabolic (i.e. extracellular matrix biosynthesis) and catabolic (i.e. extracellular matrix degradation) pathways in which articular cartilage is the principal site of tissue injury responses. The pathophysiology of OA a...... hiện toàn bộ Secreted Proteins of the Oviduct Tập 166 Số 2 - Trang 165-179 - 2000
W.C. Buhi, Idania M. Alvarez, Andrew J. Kouba
During late follicular development and estrus, the mammalian oviduct undergoes specific physiological and biochemical modifications which contribute to an optimization of the microenvironment for fertilization and early cleavage-stage embryonic development. These changes appear to be hormonally regulated by ovarian steroids, most importantly, estrogen. The hundreds of macromolecules found ...... hiện toàn bộ