Validation of the national health insurance research database with ischemic stroke cases in Taiwan

Pharmacoepidemiology and Drug Safety - Tập 20 Số 3 - Trang 236-242 - 2011
Ching‐Lan Cheng1, Yea‐Huei Kao Yang1,2, Swu‐Jane Lin3, Cheng‐Han Lee4, Mei‐Jung Lai5
1Institute of Biopharmaceutical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan
2Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
3University of Illinois at Chicago, Chicago, IL USA
4Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
5Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan

Tóm tắt

AbstractObjectiveThe National Health Insurance Research Database (NHIRD) is commonly used for pharmacoepidemiological research in Taiwan. This study evaluated the validity of the database for patients with a principal diagnosis of ischemic stroke.Study design and methodsThis cross‐sectional study compares records in the NHIRD with those in one medical center. Patients hospitalized for ischemic stroke in 1999 were identified from both databases. The discharge notes, laboratory data, and medication orders during admission and the first discharge visit were reviewed to validate ischemic stroke diagnoses and aspirin prescribing in the NHIRD. Agreement between the two databases in comorbidities of ischemic stroke diagnosis was evaluated using ICD‐9 codes.ResultsThree hundred and seventy two cases were identified from the NHIRD; among them, 364 cases (97.85%) were confirmed as ischemic stroke by radiology examination and clinical presentation. Among these confirmed cases, 344 (94.51%) were assigned ‘ischemic stroke’ as the principal diagnosis in the NHIRD. The overall agreement of comorbid diagnoses between the databases was 48.39%. The PPV for selected conditions also varied widely, from 0.50 for fracture to 1.00 for colon cancer. The accuracy of recorded aspirin prescriptions was higher in first post‐discharge visits (PPV = 0.94) than during hospitalization (PPV = 0.88).ConclusionThe accuracy of the NHIRD in recording ischemic stroke diagnoses and aspirin prescriptions was high, and the NHIRD appears to be a valid resource for population research in ischemic stroke. Copyright © 2010 John Wiley & Sons, Ltd.

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Pharmacoepidemiology and Drug Safety

Tập 20 Số 3

236-242

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