Xác thực các bài kiểm tra giải trình tự thế hệ tiếp theo metagenomic cho việc phát hiện bệnh nhân toàn cầu
Tóm tắt
Giải trình tự metagenomic có thể được sử dụng để phát hiện bất kỳ tác nhân gây bệnh nào bằng cách sử dụng giải trình tự thế hệ tiếp theo (NGS) không thiên lệch, không cần khuếch đại cụ thể cho trình tự. Bằng chứng khái niệm đã được chứng minh trong các ổ dịch bệnh truyền nhiễm không rõ nguyên nhân và ở những bệnh nhân nghi ngờ nhiễm trùng nhưng có kết quả xét nghiệm âm tính với các phương pháp truyền thống. Các bài kiểm tra NGS metagenomic có tiềm năng lớn để cải thiện chẩn đoán bệnh truyền nhiễm, đặc biệt là ở những bệnh nhân có hệ miễn dịch yếu và bệnh nhân nặng.
Từ khóa
#Giải trình tự metagenomic #phát hiện tác nhân gây bệnh #xét nghiệm NGS #bệnh truyền nhiễm #phòng thí nghiệm lâm sàng.Tài liệu tham khảo
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