Vagal Relaxation of the Stomach Experimental Re‐investigation of the Concept of the Transmission Mechanism

Wiley - Tập 64 Số 4 - Trang 453-462 - 1965
J. Martinson1
1Department of Physiology, University of Göteborg, Sweden

Tóm tắt

AbstractMartinson, J. Vagal relaxation of the stomach. Experimental re‐investigation of the concept of the transmission mechanism. Acta physiol. scand. 1965. 64. 453–462. – The vagus nerves contain efferent fibres capable of relaxing the corpus and fundus of the stomach. In experiments on cats this atropine‐resistant effect has been shown to differ in several respects from relaxation elicited by sympathetic stimulation or infusion of catecholamines. The vagal responses are more potent, their latency is shorter, and maximum response is attained at definitely lower frequencies. The responses to sympathetic stimulation wears off much more rapidly after the end of stimulation than does vagally induced gastric relaxation. Finally, the sympathetic or catecholamine gastric responses are more or less completely blocked by guanethidine or nethalide, which have hardly any effect on the vagal relaxation of the stomach. Hexamethonium inhibits vagal relaxation, and seems to be potentiated by atropine. It is concluded that the relaxation of the stomach on excitation of“high‐threshold” efferent vagal nerve fibres is mediated via preganglionic vagal fibres, which do not exert their effect by any adrenergic mechanism. It is still not possible to say what peripheral mechanism is actually responsible for this long‐lasting gastric relaxation.

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Tài liệu tham khảo

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Wiley

Tập 64 Số 4

453-462

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