Carolyn C. Huntley1, Margarita Cáceres de Costas1, Anne Drapkin Lyerly1
1Departments of Pediatrics of the Bowman Gray School of Medicine and the University of Puerto Rico School of Medicine
Tóm tắt
Fifty-one preschool children with hypereosinophilia and signs of visceral involvement were studied. The most common symptoms were pica (90%), pulmonary symptoms (86%), and fever (80%). Fourteen patients (28%) had convulsions. Hepatomegaly (encountered in 65%) was the most prominent physical finding. Anemia was present in almost half of the patients. Albumin concentrations were decreased and globulin concentrations increased in the patient group. Total gamma-globulins and gamma1 M globulins were significantly elevated. Precipitating antibody to A and B blood group substances and/or helminth antigens was found in one-half of the patients. Isohemagglutinin titers were elevated (above 1:256) in two-thirds of the patients. Sheep cell agglutination titers were slightly elevated in the patient group, and heat stable antiglobulins were found in 14 of 29 patients tested. The significance of the hypergammaglobulinemia, anemia, and central nervous system symptoms was discussed.
