Using drinking in the dark to model prenatal binge‐like exposure to ethanol in C57BL/6J mice

Developmental Psychobiology - Tập 50 Số 6 - Trang 566-578 - 2008
Stephen L. Boehm1, Eileen M. Moore1, Cherie D. Walsh1, Carly D. Gross1, Austin M. Cavelli1, Eduardo D. Gigante1, David N. Linsenbardt1
1Center for Development and Behavioral Neuroscience, Department of Psychology (Science IV, Room 230), Binghamton University—SUNY, PO Box 6000, 4400 Vestal Parkway East, Binghamton, NY 13902‐6000.

Tóm tắt

AbstractAnimal models of prenatal ethanol exposure are necessary to more fully understand the effects of ethanol on the developing embryo/fetus. However, most models employ procedures that may produce additional maternal stress beyond that produced by ethanol alone. We employed a daily limited‐access ethanol intake model called Drinking in the Dark (DID) to assess the effects of voluntary maternal binge‐like ethanol intake on the developing mouse. Evidence suggests that binge exposure may be particularly harmful to the embryo/fetus, perhaps due to the relatively higher blood ethanol concentrations achieved. Pregnant females had mean daily ethanol intakes ranging from 4.2 to 6.4 g/kg ethanol over gestation, producing blood ethanol concentrations ranging from 115 to 182 mg/dL. This level of ethanol intake produced behavioral alterations among adolescent offspring that disappeared by adulthood, including altered sensitivity to ethanol's hypnotic actions. The DID model may provide a useful tool for studying the effects of prenatal ethanol exposure in mice. © 2008 Wiley Periodicals, Inc. Dev Psychobiol 50: 566–578, 2008.

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Developmental Psychobiology

Tập 50 Số 6

566-578

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