Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury

Critical Care Medicine - Tập 39 Số 4 - Trang 711-717 - 2011
Carolyn S. Calfee1,2,3,4,5,6,7,8,9,10, Lorraine B. Ware1,2,3,4,5,6,7,8,9,10, David V. Glidden1,2,3,4,5,6,7,8,9,10, Mark D. Eisner1,2,3,4,5,6,7,8,9,10, Polly E. Parsons1,2,3,4,5,6,7,8,9,10, Bruce Thompson1,2,3,4,5,6,7,8,9,10, Michael A. Matthay1,2,3,4,5,6,7,8,9,10
1Address requests for reprints to: Carolyn S. Calfee, MD, MAS, University of California, San Francisco, Pulmonary and Critical Care Division, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143-0111. E-mail: [email protected]
2Cardiovascular Research Institute (CSC, MDE, MAM), San Francisco, CA
3Department of Medicine (BTT), Pulmonary and Critical Care Medicine Unit, and Biostatistics Unit (BTT), Massachusetts General Hospital, Boston, MA.
4Department of Medicine (LBW), Division of Allergy, Pulmonary and Critical Care, Vanderbilt University, Nashville, TN
5Department of Medicine (PEP), Division of Pulmonary and Critical Care Medicine, University of Vermont, Burlington, VT
6Dr. Eisner is a full-time employee Genentech. The remaining have not disclosed any potential conflicts of interest.
7From the Department of Medicine (CSC, MDE, MAM), Division of Pulmonary and Critical Care Medicine, Department of Anesthesia (CSC, MDE, MAM), and Department of Epidemiology and Biostatistics (DVG), University of California, San Francisco, CA
8Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (http://www.ccmjournal.com).
9Supported, in part, by contracts National Heart, Lung, and Blood Institute grant NO1-HR 46054, 46055, 46056, 46057, 46058, 46059, 46060, 46061, 46062, 46063, and 46064 with the National Heart, Lung, and Blood Institute, Bethesda, MD. Dr. Calfee was supported by grant HL090833, by the Flight Attendant Medical Research Institute, Miami, FL, and by grant KL2RR024130 from the National Center for Research Resources, a component of the National Institutes of Health, Bethesda, MD. Dr. Matthay was supported by National Heart, Lung, and Blood Institute grant HL 51856. Dr. Ware was supported by grant HL081332.
10The network participants, clinical coordination center, National Heart, Lung, and Blood Institute staff, Steering Committee, Data and Safety Monitoring Board, and Protocol Review Committee are acknowledged in the Appendix.

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