Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV

Parker, 2009, Oncolytic viral therapy of malignant glioma, Neurotherapeutics, 6, 558, 10.1016/j.nurt.2009.04.011 Grandi, 2009, Design and application of oncolytic HSV vectors for glioblastoma therapy, Expert Rev Neurother, 9, 505, 10.1586/ern.09.9 Markert, 2000, Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial, Gene Ther, 7, 867, 10.1038/sj.gt.3301205 Todo, 2008, Oncolytic virus therapy using genetically engineered herpes simplex viruses, Front Biosci, 13, 2060, 10.2741/2823 Uchida, 2013, Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus, Mol Ther, 21, 561, 10.1038/mt.2012.211 Gaur, 2007, Characterization of microRNA expression levels and their biological correlates in human cancer cell lines, Cancer Res, 67, 2456, 10.1158/0008-5472.CAN-06-2698 Karsy, 2012, Current Progress on understanding microRNAs in glioblastoma multiforme, Genes Cancer, 3, 3, 10.1177/1947601912448068 Riddick, 2011, Integration and analysis of genome-scale data from gliomas, Nat Rev Neurol, 7, 439, 10.1038/nrneurol.2011.100 Kumar, 2007, Impaired microRNA processing enhances cellular transformation and tumorigenesis, Nat Genet, 39, 673, 10.1038/ng2003 Tischer, 2006, Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli, Biotechniques, 40, 191, 10.2144/000112096 Gierasch, 2006, Construction and characterization of bacterial artificial chromosomes containing HSV-1 strains 17 and KOS, J Virol Methods, 135, 197, 10.1016/j.jviromet.2006.03.014 Bennett, 2002, Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer, Cancer Gene Ther, 9, 935, 10.1038/sj.cgt.7700510 Szymczak, 2005, Development of 2A peptide-based strategies in the design of multicistronic vectors, Expert Opin Biol Ther, 5, 627, 10.1517/14712598.5.5.627 Doronina, 2008, Site-specific release of nascent chains from ribosomes at a sense codon, Mol Cell Biol, 28, 4227, 10.1128/MCB.00421-08 Uchida, 2010, A double mutation in glycoprotein gB compensates for ineffective gD-dependent initiation of herpes simplex virus type 1 infection, J Virol, 84, 12200, 10.1128/JVI.01633-10 Uchida, 2013, Novel mutations in gB and gH circumvent the requirement for known gD receptors in herpes simplex virus 1 entry and cell-to-cell spread, J Virol, 87, 1430, 10.1128/JVI.02804-12 Cao, 2007, A functional study of miR-124 in the developing neural tube, Genes Dev, 21, 531, 10.1101/gad.1519207 Fujioka, 1999, Interleukin-18 protects mice against acute herpes simplex virus type 1 infection, J Virol, 73, 2401, 10.1128/JVI.73.3.2401-2409.1999 Manickan, 1995, Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes, J Immunol, 155, 259, 10.4049/jimmunol.155.1.259 Sethi, 1983, Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specific and H-2-restricted cytotoxic T lymphocytes, J Gen Virol, 64, 443, 10.1099/0022-1317-64-2-443 Currier, 2008, Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide, Mol Ther, 16, 879, 10.1038/mt.2008.49 Hong, 2010, Ectopic matrix metalloproteinase-9 expression in human brain tumor cells enhances oncolytic HSV vector infection, Gene Ther, 17, 1200, 10.1038/gt.2010.66 Lee, 2009, MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells, Clin Cancer Res, 15, 5126, 10.1158/1078-0432.CCR-09-0051 Kelly, 2010, Attenuation of vesicular stomatitis virus encephalitis through microRNA targeting, J Virol, 84, 1550, 10.1128/JVI.01788-09 Cawood, 2009, Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells, PLoS Pathog, 5, e1000440, 10.1371/journal.ppat.1000440 Ylösmäki, 2008, Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific microRNA, J Virol, 82, 11009, 10.1128/JVI.01608-08 Barnes, 2008, Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines, Cell Host Microbe, 4, 239, 10.1016/j.chom.2008.08.003 Zhang, 2009, MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a, J Mol Med (Berl), 87, 43, 10.1007/s00109-008-0403-6 Shi, 2008, hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells, Brain Res, 1236, 185, 10.1016/j.brainres.2008.07.085 Silber, 2008, miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells, BMC Med, 6, 14, 10.1186/1741-7015-6-14 Maiorano, 2010, The pro-differentiating role of miR-124: indicating the road to become a neuron, RNA Biol, 7, 528, 10.4161/rna.7.5.12262 Wei, 2013, miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma, Cancer Res, 73, 3913, 10.1158/0008-5472.CAN-12-4318 Lavon, 2010, Gliomas display a microRNA expression profile reminiscent of neural precursor cells, Neuro Oncol, 12, 422, 10.1093/neuonc/nop061 Karpowicz, 2009, E-cadherin regulates neural stem cell self-renewal, J Neurosci, 29, 3885, 10.1523/JNEUROSCI.0037-09.2009 Katoh, 2008, Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review), Int J Mol Med, 22, 271 Ocaña, 2008, A new regulatory loop in cancer-cell invasion, EMBO Rep, 9, 521, 10.1038/embor.2008.84 Verhaak, 2010, Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1, Cancer Cell, 17, 98, 10.1016/j.ccr.2009.12.020 Nduom, 2012, Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment, Cancer J, 18, 100, 10.1097/PPO.0b013e3182452e0d He, 2012, Targeting glioblastoma stem cells: cell surface markers, Curr Med Chem, 19, 6050, 10.2174/0929867311209066050 Kambara, 2005, An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor, Cancer Res, 65, 2832, 10.1158/0008-5472.CAN-04-3227 Xia, 2012, Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells, J Biol Chem, 287, 9962, 10.1074/jbc.M111.332627 Macdonald, 2012, Genome sequence of herpes simplex virus 1 strain KOS, J Virol, 86, 6371, 10.1128/JVI.00646-12 Kaji, 2009, Virus-free induction of pluripotency and subsequent excision of reprogramming factors, Nature, 458, 771, 10.1038/nature07864 Krisky, 1997, Rapid method for construction of recombinant HSV gene transfer vectors, Gene Ther, 4, 1120, 10.1038/sj.gt.3300497