Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV
Lucia Mazzacurati1,2, Marco Marzulli1, Bonnie Reinhart1, Yoshitaka Miyagawa1, Hiroaki Uchida3, William F Goins1, Aofei Li1,4, Balveen Kaur5, Michael Caligiuri6,7, Timothy Cripe8,9, Nino Chiocca10, Nduka Amankulor11, Justus B Cohen1, Joseph C Glorioso1, Paola Grandi1,11,12
1Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
2Graduate Program in Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
3Laboratory of Oncology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
4Tsinghua University School of Medicine, Beijing, China
5Department of Neurological Surgery, College of Medicine, Ohio State University, Columbus, Ohio, USA
6Division of Hematology, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, Ohio, USA
7Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
8Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA
9Division of Hematology/Oncology/Blood and Marrow Transplantation, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA
10Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
11Department of Neurological Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
12SVeB University of Ferrara, Ferrara, Italy