Cập nhật hướng dẫn S3 về chẩn đoán, phòng ngừa và điều trị bệnh loãng xương

Springer Science and Business Media LLC - Tập 56 - Trang 597-605 - 2023
Michael Drey1, Sven Otto2, Friederike Thomasius3, Ralf Schmidmaier1
1Medizinische Klinik IV, Schwerpunkt Geriatrie, LMU Klinikum München, München, Deutschland
2Klinik und Poliklinik für Mund-Kiefer-Gesichtschirurgie, LMU Klinikum München, München, Deutschland
3Frankfurter Hormon & Osteoporosezentrum, Frankfurt, Deutschland

Tóm tắt

Thông qua một mô hình đánh giá nguy cơ gãy xương mới, mục tiêu là giảm thiểu khoảng cách trong điều trị bệnh loãng xương. Bệnh nhân từ 70 tuổi trở lên nên được kiểm tra chẩn đoán bệnh loãng xương. Một ngưỡng rủi ro bổ sung sẽ cho phép bệnh nhân có nguy cơ gãy xương rất cao (≥ 10% trong 3 năm đối với gãy xương đùi và đốt sống) được điều trị bằng các chế phẩm osteoanabole. Việc sử dụng các chế phẩm osteoanabole yêu cầu phải có liệu pháp chống tái hấp thu tiếp theo trong quá trình điều trị. Việc bắt đầu một liệu pháp cụ thể cho bệnh loãng xương không nên bị trì hoãn do tỷ lệ sự kiện thấp gây ra bởi hoại tử xương hàm, thông qua một biện pháp phòng ngừa nha khoa. Để cải thiện mức độ tuân thủ điều trị, cần tìm kiếm các giải pháp cá nhân hóa dựa trên sự hợp tác giữa bệnh nhân, người thân và bác sĩ. Một cuộc khảo sát về sự ngã thường xuyên nên được thực hiện từ độ tuổi 70 trở lên, bao gồm cả bài kiểm tra Timed-up-and-go.

Từ khóa

#Osteoporose #Frakturrisiko #Therapieadhärenz #Chẩn đoán loãng xương #Điều trị hoại tử xương hàm

Tài liệu tham khảo

Kanis JA, Norton N, Harvey NC et al (2021) SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos 16:82. https://doi.org/10.1007/s11657-020-00871-9 Glüer C‑C, Engelke K, Thomasius F (2023) Das Konzept des DVO Frakturrisikorechners. Osteologie 32:123–132. https://doi.org/10.1055/a-2053-7047 van Geel TACM, van Helden S, Geusens PP et al (2009) Clinical subsequent fractures cluster in time after first fractures. Ann Rheum Dis 68:99–102. https://doi.org/10.1136/ard.2008.092775 Harvey NC, Odén A, Orwoll E et al (2018) Falls predict fractures independently of FRAX probability: a meta-analysis of the osteoporotic fractures in men (mrOS) study. J Bone Miner Res 33:510–516. https://doi.org/10.1002/jbmr.3331 Ryg J, Rejnmark L, Overgaard S et al (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977–2001. J Bone Miner Res 24:1299–1307. https://doi.org/10.1359/jbmr.090207 van Staa TP, Leufkens HG, Abenhaim L et al (2005) Use of oral corticosteroids and risk of fractures. J Bone Miner Res 20:1486–1493. https://doi.org/10.1359/jbmr.2005.20.8.1486 Wustrack R, Seeman E, Bucci-Rechtweg C et al (2012) Predictors of new and severe vertebral fractures: results from the HORIZON pivotal fracture trial. Osteoporos Int 23:53–58. https://doi.org/10.1007/s00198-011-1664-4 Kendler DL, Marin F, Zerbini CAF et al (2018) Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet 391:230–240. https://doi.org/10.1016/S0140-6736(17)32137-2 Saag KG, Petersen J, Brandi ML et al (2017) Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med 377:1417–1427. https://doi.org/10.1056/nejmoa1708322 Lindsay R, Scheele WH, Neer R et al (2004) Sustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis. Arch Intern Med 164:2024–2030. https://doi.org/10.1001/archinte.164.18.2024 McClung MR, Brown JP, Diez-Perez A et al (2018) Effects of 24 months of treatment with romosozumab followed by 12 months of denosumab or placebo in postmenopausal women with low bone mineral density: a randomized, double-blind, phase 2, parallel group study. J Bone Miner Res 33:1397–1406. https://doi.org/10.1002/jbmr.3452 Cummings SR, Ferrari S, Eastell R et al (2018) Vertebral fractures after discontinuation of denosumab: a post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension. J Bone Miner Res 33:190–198. https://doi.org/10.1002/jbmr.3337 Tsourdi E, Zillikens MC, Meier C et al (2021) Fracture risk and management of discontinuation of denosumab therapy: a systematic review and position statement by ECTS. J Clin Endocrinol Metab 106:264–281. https://doi.org/10.1210/clinem/dgaa756 Otto S, Ristow O (2022) Antiresorptiva-assoziierte Kiefernekrosen – ein Update. MKG-Chirurg 15:59–74. https://doi.org/10.1007/s12285-021-00347-w Rupp M, Walter N, Pfeifer C et al (2021) Originalarbeit: Inzidenz von Frakturen in der Erwachsenenpopulation in Deutschland. Dtsch Ärztebl Int 118:665–669. https://doi.org/10.3238/arztebl.m2021.0238 Khan AA, Morrison A, Kendler DL et al (2017) Case-based review of osteonecrosis of the jaw (ONJ) and application of the international recommendations for management from the international task force on ONJ. J Clin Densitom 20:8–24. https://doi.org/10.1016/j.jocd.2016.09.005 Nikolaus T, Kruse W, Bach M et al (1996) Elderly patients’ problems with medication. An in-hospital and follow-up study. Eur J Clin Pharmacol 49:255–259. https://doi.org/10.1007/BF00226324 Hadji P, Felsenberg D, Amling M et al (2014) The non-interventional bonviva intravenous versus alendronate (VIVA) study: real-world adherence and persistence to medication, efficacy, and safety, in patients with postmenopausal osteoporosis. Osteoporos Int 25:339–347. https://doi.org/10.1007/s00198-013-2515-2 Reyes C, Tebe C, Martinez-Laguna D et al (2017) One and two-year persistence with different anti-osteoporosis medications: a retrospective cohort study. Osteoporos Int 28:2997–3004. https://doi.org/10.1007/s00198-017-4144-7 Larsson BAM, Johansson L, Johansson H et al (2021) The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density. Osteoporos Int 32:75–84. https://doi.org/10.1007/s00198-020-05681-w Dautzenberg L, Beglinger S, Tsokani S et al (2021) Interventions for preventing falls and fall-related fractures in community-dwelling older adults: a systematic review and network meta-analysis. J Am Geriatr Soc 69:2973–2984. https://doi.org/10.1111/jgs.17375 Wang Q, Jiang X, Shen Y et al (2020) Effectiveness of exercise intervention on fall-related fractures in older adults: a systematic review and meta-analysis of randomized controlled trials. BMC Geriatr 20:322. https://doi.org/10.1186/s12877-020-01721-6 Ming Y, Zecevic AA, Hunter SW et al (2021) Medication review in preventing older adults’ fall-related injury: a systematic review & meta-analysis. Can Geriatr J 24:237–250. https://doi.org/10.5770/CGJ.24.478 Hauff J, Rottenkolber M, Oehler P et al (2023) Single and combined use of fall-risk-increasing drugs and fracture risk: a population-based case-control study. Age Ageing. https://doi.org/10.1093/ageing/afad079 Deutz NEP, Bauer JM, Barazzoni R, Biolo G, Boirie Y, Bosy-Westphal A, Cederholm T, Cruz-Jentoft A, Krznaric Z, Nair KS, Singer P, Teta D, Tipton K, Calder PC (2012) Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN expert. Group 100:130–134. https://doi.org/10.1016/j.clnu.2014.04.007.Protein Wong RMY, Wong H, Zhang N et al (2019) The relationship between sarcopenia and fragility fracture—a systematic review. Osteoporos Int 30:541–553. https://doi.org/10.1007/s00198-018-04828-0 Groenendijk I, den Boeft L, van Loon LJC, de Groot LCPGM (2019) High versus low dietary protein intake and bone health in older adults: a systematic review and meta-analysis. Comput Struct Biotechnol J 17:1101–1112. https://doi.org/10.1016/j.csbj.2019.07.005 AWMF (2023) S3-Leitlinie „Antiresorptiva-assoziierte Kiefernekrosen (AR-ONJ)“ (AWMF-Register-Nr. 007-091). https://www.awmf.org