Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

Immunological Reviews - Tập 234 Số 1 - Trang 142-162 - 2010
Melissa Swiecki1, Marco Colonna1
1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

Tóm tắt

Summary:  Plasmacytoid dendritic cells (pDCs) are bone marrow‐derived cells that secrete large amounts of type I interferon (IFN) in response to viruses. Type I IFNs are pleiotropic cytokines with antiviral activity that also enhance innate and adaptive immune responses. Viruses trigger activation of pDCs and type I IFN responses mainly through the Toll‐like receptor pathway. However, a variety of activating and inhibitory pDC receptors fine tune the amplitude of type I IFN responses. Chronic activation and secretion of type I IFN in the absence of infection can promote autoimmune diseases. Furthermore, while activated pDCs promote immunity and autoimmunity, resting or alternatively activated pDCs may be tolerogenic. The various roles of pDCs have been extensively studied in vitro and in vivo with depleting antibodies. However, depleting antibodies cross‐react with other cell types that are critical for eliciting protective immunity, potentially yielding ambiguous phenotypes. Here we discuss new approaches to assess pDC functions in vivo and provide preliminary data on their potential roles during viral infections. Such approaches would also prove useful in the more specific evaluation of how pDCs mediate tolerance and autoimmunity. Finally, we discuss the emergent role of pDCs and one of their receptors, tetherin, in human immunodeficiency virus pathogenesis.

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Tài liệu tham khảo

10.1038/ni1141

10.1146/annurev.immunol.23.021704.115633

Muller‐Hermelink HK, 1983, Malignant lymphoma of plasmacytoid T‐cells. Morphologic and immunologic studies characterizing a special type of T‐cell, Am J Surg Pathol, 7, 849

10.1159/000205419

Facchetti F, 1988, Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin, Am J Pathol, 133, 15

10.1084/jem.185.6.1101

10.1126/science.283.5405.1183

10.1126/science.284.5421.1835

10.1038/11360

Ronnblom L, 1983, Characterization of interferons induced by bacteria and interferon‐producing leukocytes in human peripheral blood, Infect Immun, 40, 126, 10.1128/iai.40.1.126-132.1983

Perussia B, 1985, A leukocyte subset bearing HLA‐DR antigens is responsible for in vitro alpha interferon production in response to viruses, Nat Immun Cell Growth Regul., 4, 120

10.1002/jlb.43.4.323

10.1016/0163-7258(93)90021-5

Ferbas JJ, 1994, CD4+ blood dendritic cells are potent producers of IFN‐alpha in response to in vitro HIV‐1 infection, J Immunol, 152, 4649, 10.4049/jimmunol.152.9.4649

10.1038/ni736

10.1084/jem.194.8.1171

10.1182/blood.V98.13.3520

10.4049/jimmunol.165.11.6037

10.1084/jem.194.12.1823

10.1182/blood-2002-02-0638

10.1084/jem.20052454

10.4049/jimmunol.0802008

10.1097/00000478-200311000-00015

10.1182/blood-2007-10-117531

10.1182/blood-2005-09-3746

10.1182/blood-2005-09-3842

10.4049/jimmunol.177.5.3260

10.4049/jimmunol.0800185

10.4049/jimmunol.174.8.4621

10.1182/blood-2004-09-3388

10.4049/jimmunol.174.11.6657

10.1073/pnas.0609180104

10.1038/ni.1658

10.4049/jimmunol.0901524

10.1038/nm1352

10.1038/nm1356

10.1084/jem.20070991

10.1038/nri1996

10.1038/ni1522

10.1016/0046-8177(89)90248-7

10.1093/ajcp/92.1.42

10.1016/S0002-9440(10)61689-6

10.1093/intimm/dxh093

10.1084/jem.20051035

Nagano Y, 1954, [Immunizing property of vaccinia virus inactivated by ultraviolets rays.], C R Seances Soc Biol Fil, 148, 1700

Lindenmann J, 1957, Studies on the production, mode of action and properties of interferon, Br J Exp Pathol, 38, 551

10.1111/j.0105-2896.2004.00204.x

10.1084/jem.20011666

10.1084/jem.20041930

10.4049/jimmunol.0804315

10.1084/jem.189.3.521

10.1016/S0952-7915(02)00354-0

10.1084/jem.20050821

10.1111/j.0105-2896.2006.00382.x

10.1038/nri1001

10.1016/S1074-7613(01)00154-6

10.1126/science.1064890

10.1089/10799900260442494

10.1038/ni978

10.1016/S1074-7613(01)00126-1

10.1016/S1074-7613(03)00208-5

10.1182/blood-2003-08-2972

10.4049/jimmunol.169.12.6673

10.4049/jimmunol.169.11.6079

10.1084/jem.20020437

10.1016/j.immuni.2008.09.002

10.1038/ni1112

10.1038/ni.1669

10.1038/nature07405

10.1126/science.1136880

10.1084/jem.20030162

10.1073/pnas.0403555101

10.4049/jimmunol.178.6.3363

10.1038/nature03547

10.1182/blood-2008-12-192344

10.1126/science.1132998

10.1126/science.1132505

10.1016/j.immuni.2007.08.012

10.1016/j.chom.2008.05.003

10.1196/annals.1443.020

10.1038/nature03464

10.1038/ni.1645

10.1038/nature06730

10.1093/intimm/dxh318

10.1084/jem.20060401

10.1016/j.coi.2006.11.004

10.1038/79747

10.1002/eji.200737944

10.1038/nri2358

10.1007/s10875-009-9284-x

10.1073/pnas.0710351105

10.1084/jem.20080718

10.1038/ni1244

10.1371/journal.pbio.0050248

10.1002/eji.200737711

10.1038/nature07537

10.1182/blood-2004-12-4802

10.1182/blood-2007-03-081398

10.4049/jimmunol.171.6.3296

10.1172/JCI23025

10.1016/j.immuni.2006.08.010

10.1038/nri1957

10.1182/blood-2007-12-127951

10.1111/j.1600-065X.1999.tb01372.x

10.1002/eji.200636195

10.1084/jem.20011672

10.1002/1521-4141(200201)32:1<97::AID-IMMU97>3.0.CO;2-Y

10.4049/jimmunol.171.12.6466

10.1016/j.immuni.2004.06.007

10.1016/S1074-7613(02)00365-5

10.1002/eji.200838470

10.1016/j.cell.2008.09.016

10.1128/JVI.69.4.2153-2158.1995

10.1073/pnas.0400937101

Bachmann MF, 1996, Immunology Methods Manual, 1897

10.1084/jem.20041961

10.1038/nature04651

10.4049/jimmunol.182.2.871

Huneycutt BS, 1993, Central neuropathogenesis of vesicular stomatitis virus infection of immunodeficient mice, J Virol, 67, 6698, 10.1128/jvi.67.11.6698-6706.1993

10.1007/978-3-540-71329-6_16

10.1128/JVI.01640-07

10.1016/B978-012442710-5/50218-5

10.1007/978-1-4684-7032-1

10.1016/S1074-7613(00)80308-8

10.1007/978-3-642-56055-2_6

10.1038/ni1136

10.1002/eji.200838282

10.1097/00002030-200100005-00016

10.1006/clim.2001.5111

10.1182/blood.V98.10.3016

10.1182/blood.V98.8.2574

10.1182/blood.V98.4.906

10.4049/jimmunol.168.9.4796

10.1086/345957

10.1086/430931

10.1093/infdis/148.6.962

10.4049/jimmunol.176.9.5644

10.1007/s10875-004-6250-5

10.4049/jimmunol.167.4.1862

10.1128/JVI.78.10.5223-5232.2004

10.1073/pnas.0800370105

10.1182/blood-2008-06-162651

10.1371/journal.ppat.1000413

10.1172/JCI26032

10.1016/j.immuni.2007.07.021

10.4049/jimmunol.173.12.7269

10.1371/journal.pone.0000458

10.1073/pnas.0600363103

10.1016/j.clim.2006.09.016

10.1016/j.clim.2007.08.015

10.1371/journal.pone.0002961

10.1182/blood-2006-07-034785

10.1172/JCI34823

10.1038/nm.2004

10.1016/0888-7543(95)80171-H

10.1034/j.1600-0854.2003.00129.x

10.1084/jem.20090547

10.1111/j.1365-2567.2005.02177.x

10.1038/nature06553

10.1016/j.chom.2008.03.001

10.1128/JVI.02211-08

10.1073/pnas.0813223106

10.1371/journal.ppat.1000300

10.1016/j.chom.2009.01.009

10.1128/JVI.01800-08

10.1371/journal.ppat.1000450

10.1371/journal.ppat.1000443

10.1128/JVI.00242-09

10.1128/JVI.00620-09

10.1371/journal.ppat.1000574

10.1128/JVI.01515-09

10.1371/journal.ppat.1000429

10.1016/j.chom.2009.05.008

10.1073/pnas.0811014106

10.1371/journal.ppat.0020107

10.1128/JVI.00597-09

10.1080/08916930310001602128

10.1182/blood-2005-07-2650

10.1016/j.cytogfr.2007.10.006

10.1016/j.coi.2008.06.008

10.1097/BOR.0b013e32832e089e

10.1080/08916930310001625952

10.1038/sj.gene.6363966

10.1073/pnas.0337679100

10.1084/jem.20021553

10.1073/pnas.0408506102

10.1084/jem.20050500

10.1038/nature06116

10.1073/pnas.0806439105

10.1002/eji.200839179

10.4049/jimmunol.180.10.6457

10.1172/JCI33342

10.1016/j.immuni.2008.03.011

10.1084/jem.20040976

10.1084/jem.20040769

10.1084/jem.20040712

10.1371/journal.ppat.1000355

10.1146/annurev.immunol.21.120601.141040

10.1038/nm1201-1339

10.1084/jem.20040035

10.1016/j.immuni.2008.06.017

10.4049/jimmunol.179.5.2690

10.1038/ni1333

10.4049/jimmunol.171.4.1652

10.4049/jimmunol.173.6.3748

10.1172/JCI21583

10.1172/JCI31911

10.1182/blood-2008-12-195354

10.4049/jimmunol.0900986

10.1084/jem.20061660

10.4049/jimmunol.166.9.5530

Jahrsdorfer B, 2009, Plasmacytoid dendritic cells suppress T cell expansion by a mechanism involving active granzyme B secretion

10.4049/jimmunol.172.7.4253

10.1016/j.immuni.2007.07.013

10.1182/blood-2006-03-007757

10.1016/j.immuni.2005.10.008

10.1002/eji.200838397

10.1084/jem.20082394

10.1016/j.immuni.2008.10.012

10.1084/jem.20052359

10.4049/jimmunol.177.9.6263

10.1182/blood-2006-05-023770

10.1016/j.immuni.2008.12.017

10.1084/jem.20071365

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Immunological Reviews

Tập 234 Số 1

142-162

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