Understanding Ebola: the 2014 epidemic
Tóm tắt
Near the end of 2013, an outbreak of Zaire ebolavirus (EBOV) began in Guinea, subsequently spreading to neighboring Liberia and Sierra Leone. As this epidemic grew, important public health questions emerged about how and why this outbreak was so different from previous episodes. This review provides a synthetic synopsis of the 2014–15 outbreak, with the aim of understanding its unprecedented spread. We present a summary of the history of previous epidemics, describe the structure and genetics of the ebolavirus, and review our current understanding of viral vectors and the latest treatment practices. We conclude with an analysis of the public health challenges epidemic responders faced and some of the lessons that could be applied to future outbreaks of Ebola or other viruses.
Tài liệu tham khảo
2014 Ebola Outbreak in West Africa - Case Counts. Center for Disease Control and Prevention. 2016.
http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/case-counts.html
. Accessed 5 Sept 2016.
citation_journal_title=N Engl J Med; citation_title=Ebola virus disease in West Africa — The first 9 months of the epidemic and forward projections; citation_author=; citation_volume=371; citation_issue=16; citation_publication_date=2014; citation_pages=1481-95; citation_doi=10.1056/NEJMoa1411100; citation_id=CR2
Toner E, Adalja A, and Inglesby T. A Primer on Ebola for clinicians. Disaster Med Public Health Prep. 2014; FirstView: 1–5. doi:
10.1017/dmp.2014.115
.
citation_journal_title=Viruses; citation_title=Filoviruses in bats: current knowledge and future directions; citation_author=KJ Olival, DT Hayman; citation_volume=6; citation_issue=4; citation_publication_date=2014; citation_pages=1759-88; citation_doi=10.3390/v6041759; citation_id=CR4
Griffiths A, Andrew H, Robert D, Olena S, Ricardo C. Jr., and Jean L. P. Chapter 24: Ebola Virus Infection. In: Viral Hemorrhagic Fevers. CRC Press Taylor and Fracis Group. Boca Raton, Florida; 2014. 435–56.
citation_journal_title=Annu Rev Pathol; citation_title=Pathogenesis of the viral hemorrhagic fevers; citation_author=S Paessler, DH Walker; citation_volume=8; citation_issue=1; citation_publication_date=2013; citation_pages=411-40; citation_doi=10.1146/annurev-pathol-020712-164041; citation_id=CR6
citation_title=Filoviruses. Supplement 20. Archives of virology; citation_publication_date=2008; citation_id=CR7; citation_author=JH Kuhn; citation_publisher=Springer-Verlag/Wien
citation_journal_title=Mol Biol Evol; citation_title=The origin and evolution of Ebola and Marburg viruses; citation_author=Y Suzuki, T Gojobori; citation_volume=14; citation_issue=8; citation_publication_date=1997; citation_pages=800-6; citation_doi=10.1093/oxfordjournals.molbev.a025820; citation_id=CR8
citation_journal_title=PLoS Biol; citation_title=Wave-like spread of Ebola Zaire; citation_author=PD Walsh, R Biek, LA Real; citation_volume=3; citation_issue=11; citation_publication_date=2005; citation_pages=1946-53; citation_doi=10.1371/journal.pbio.0030371; citation_id=CR9
citation_journal_title=Science; citation_title=Delays hinder Ebola genomics; citation_author=G Vogel; citation_volume=346; citation_issue=6210; citation_publication_date=2014; citation_pages=684-5; citation_doi=10.1126/science.346.6210.684; citation_id=CR10
Callaway, Ewen. 2015. Ebola’s Fast Evolution Questioned : Nature News & Comment.
http://www.nature.com/news/ebola-s-fast-evolution-questioned-1.17200
. Accessed 26 Mar 2015.
citation_journal_title=Science; citation_title=Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak; citation_author=SK Gire, A Goba, KG Andersen, RS Sealfon, DJ Park, L Kanneh, S Jalloh; citation_volume=345; citation_issue=6202; citation_publication_date=2014; citation_pages=1369-72; citation_doi=10.1126/science.1259657; citation_id=CR12
Spielman SJ, Austin GM, and Claus OW. Increased evolutionary rate in the 2014 West African Ebola outbreak is due to transient polymorphism and not positive selection. bioRxiv. 2014;011429. doi:
10.1101/011429
.
Hoenen T, Safronetz D, Groseth A, Wollenberg KR, Koita OA, Diarra B, Fall IS, et al. “Mutation rate and genotype variation of ebola virus from mali case sequences.” Science. 2015;aaa5646. doi:
10.1126/science.aaa5646
.
citation_journal_title=Nature; citation_title=Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa; citation_author=MW Carroll, DA Matthews, JA Hiscox, MJ Elmore, G Pollakis, A Rambaut, R Hewson; citation_publication_date=2015; citation_id=CR15
citation_journal_title=Nature; citation_title=Distinct lineages of ebola virus in Guinea during the 2014 West African epidemic; citation_author=E Simon-Loriere, O Faye, O Faye, L Koivogui, N Magassouba, S Keita, J-M Thiberge; citation_publication_date=2015; citation_id=CR16
citation_journal_title=Int J Infect Dis; citation_title=Containing a haemorrhagic fever epidemic: the Ebola experience in Uganda; citation_author=M Lamunu, JJ Lutwama, J Kamugisha, A Opio, J Nambooze, N Ndayimirije, S Okware; citation_volume=8; citation_issue=1; citation_publication_date=2004; citation_pages=27-37; citation_doi=10.1016/j.ijid.2003.04.001; citation_id=CR17
citation_journal_title=BMC Infect Dis; citation_title=Ebola Haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned; citation_author=M Borchert, I Mutyaba, MD Kerkhove, J Lutwama, H Luwaga, G Bisoborwa, J Turyagaruka; citation_volume=11; citation_issue=1; citation_publication_date=2011; citation_pages=357; citation_doi=10.1186/1471-2334-11-357; citation_id=CR18
citation_journal_title=Nature; citation_title=Fruit bats as reservoirs of Ebola virus; citation_author=EM Leroy, B Kumulungui, X Pourrut, P Rouquet, A Hassanin, P Yaba, A Délicat, JT Paweska, J-P Gonzalez, R Swanepoel; citation_volume=438; citation_issue=7068; citation_publication_date=2005; citation_pages=575-6; citation_doi=10.1038/438575a; citation_id=CR19
citation_journal_title=Science; citation_title=Multiple Ebola virus transmission events and rapid decline of Central African wildlife; citation_author=EM Leroy, P Rouquet, P Formenty, S Souquière, A Kilbourne, J-M Froment, M Bermejo; citation_volume=303; citation_issue=5656; citation_publication_date=2004; citation_pages=387-90; citation_doi=10.1126/science.1092528; citation_id=CR20
“Ebola. The Search for a Cure”. BBC Horizon. 2014.
http://www.bbc.co.uk/programmes/b04hcthj
.
citation_journal_title=J Global Infect Dis; citation_title=Infection control during filoviral hemorrhagic fever outbreaks; citation_author=V Raabe, M Borchert; citation_volume=4; citation_issue=1; citation_publication_date=2012; citation_pages=69-74; citation_doi=10.4103/0974-777X.93765; citation_id=CR22
“One Year into the Ebola Epidemic: A Deadly, Tenacious and Unforgiving Virus.” WHO. 2015.
http://www.who.int/csr/disease/ebola/one-year-report/introduction/en/
. Accessed 5 Sept 2016.
Del Rio C, Mehta AK, Lyon GM III, and Guarner J. Ebola hemorrhagic fever in 2014: the tale of an evolving epidemic Ebola hemorrhagic fever in 2014. Ann Intern Med. 2014. doi:
10.7326/M14-1880
.
citation_journal_title=Ann Glob Health; citation_title=Transmission of Ebola virus disease: an overview; citation_author=S Rewar, D Mirdha; citation_volume=80; citation_issue=6; citation_publication_date=2014; citation_pages=444-51; citation_doi=10.1016/j.aogh.2015.02.005; citation_id=CR25
How Is the End of an Ebola Outbreak Decided and Declared? 2015. WHO.
http://www.who.int/csr/disease/ebola/declaration-ebola-end/en/
. Accessed 10 Feb 2015.
citation_journal_title=Nature; citation_title=Ebola: learn from the past; citation_author=DL Heymann; citation_volume=514; citation_issue=7522; citation_publication_date=2014; citation_pages=299-300; citation_doi=10.1038/514299a; citation_id=CR27
citation_journal_title=J Infect Dis; citation_title=Transmission of Ebola hemorrhagic fever: a study of risk factors in family members, Kikwit, Democratic Republic of the Congo, 1995; citation_author=SF Dowell, R Mukunu, TG Ksaizek, AS Khan, PE Rollin, CJ Peters; citation_volume=179; citation_issue=Suppl 1; citation_publication_date=1999; citation_pages=S87-91; citation_doi=10.1086/514284; citation_id=CR28
citation_journal_title=J Infect Dis; citation_title=Assessment of the risk of Ebola virus transmission from bodily fluids and Fomites; citation_author=DG Bausch, JS Towner, SF Dowell, F Kaducu, M Lukwiya, A Sanchez, ST Nichol, TG Ksiazek, PE Rollin; citation_volume=196; citation_issue=s2; citation_publication_date=2007; citation_pages=S142-7; citation_doi=10.1086/520545; citation_id=CR29
citation_journal_title=BMJ Open; citation_title=Systematic review of the literature on viral persistence and sexual transmission from recovered Ebola survivors: evidence and recommendations; citation_author=A Thorson, P Formenty, C Lofthouse, N Broutet; citation_volume=6; citation_issue=1; citation_publication_date=2016; citation_pages=e008859; citation_doi=10.1136/bmjopen-2015-008859; citation_id=CR30
citation_journal_title=N Engl J Med; citation_title=Molecular evidence of sexual transmission of Ebola virus; citation_author=SE Mate, JR Kugelman, TG Nyenswah, JT Ladner, MR Wiley, T Cordier-Lassalle, A Christie; citation_volume=373; citation_issue=25; citation_publication_date=2015; citation_pages=2448-54; citation_doi=10.1056/NEJMoa1509773; citation_id=CR31
Q&A: How Does MSF Care for Patients Suffering from Ebola? 2015. MSF USA.
http://www.doctorswithoutborders.org/article/qa-how-does-msf-care-patients-suffering-ebola
. Accessed 5 Sept 2016.
citation_journal_title=Intensive Care Med; citation_title=Ebola care and research protocols; citation_author=A Perner, RA Fowler, R Bellomo, I Roberts; citation_volume=41; citation_issue=1; citation_publication_date=2015; citation_pages=111-4; citation_doi=10.1007/s00134-014-3568-1; citation_id=CR33
Treatment Ebola Hemorrhagic Fever. 2015. Center for Disease Control and Prevention.
http://www.cdc.gov/vhf/ebola/treatment/
. Accessed 5 Mar 2015.
citation_journal_title=MBio; citation_title=Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics; citation_author=JR Kugelman, M Sanchez-Lockhart, KG Andersen, S Gire, DJ Park, R Sealfon, AE Lin; citation_volume=6; citation_issue=1; citation_publication_date=2015; citation_pages=e02227-14; citation_doi=10.1128/mBio.02227-14; citation_id=CR35
Butler, Declan. First Trials of Blood-Based Ebola Therapy Kick off : Nature News & Comment. 2015.
http://www.nature.com/news/first-trials-of-blood-based-ebola-therapy-kick-off-1.16564
. Accessed 22 May 2016.
citation_journal_title=Blood Purif; citation_title=Extracorporeal virus elimination for the treatment of severe Ebola virus disease - first experience with lectin affinity plasmapheresis; citation_author=S Buttner, K Benjamin, D Olga, E Markus, F Tilo, R Sarah, E Jurgen, B Stephan, R Claudio, G Helmut; citation_volume=38; citation_publication_date=2015; citation_pages=286-91; citation_doi=10.1159/000375229; citation_id=CR37
citation_journal_title=Science; citation_title=Modeling infectious disease dynamics in the complex landscape of global health; citation_author=H Heesterbeek, RM Anderson, V Andreasen, S Bansal, D Angelis, C Dye, KT Eames; citation_volume=347; citation_issue=6227; citation_publication_date=2015; citation_pages=aaa4339; citation_doi=10.1126/science.aaa4339; citation_id=CR38
citation_journal_title=BMC Med; citation_title=Transmission dynamics and control of Ebola Virus Disease (EVD): a review; citation_author=G Chowell, H Nishiura; citation_volume=12; citation_issue=1; citation_publication_date=2014; citation_pages=196; citation_doi=10.1186/s12916-014-0196-0; citation_id=CR39
citation_journal_title=Trends Ecol Evol; citation_title=Emerging pathogens: the epidemiology and evolution of species jumps; citation_author=ME Woolhouse, DT Haydon, R Antia; citation_volume=20; citation_issue=5; citation_publication_date=2005; citation_pages=238-44; citation_doi=10.1016/j.tree.2005.02.009; citation_id=CR40
citation_journal_title=PLoS Curr; citation_title=Estimating the reproduction number of Ebola virus (EBOV) during the 2014 outbreak in West Africa; citation_author=CL Althaus; citation_publication_date=2014; citation_id=CR41
citation_journal_title=Clin Infect Dis; citation_title=Epidemiological and viral genomic sequence analysis of the 2014 Ebola outbreak reveals clustered transmission; citation_author=SV Scarpino, A Iamarino, C Wells, D Yamin, M Ndeffo-Mbah, NS Wenzel, SJ Fox; citation_publication_date=2014; citation_id=CR42
citation_title=Making a difference: the global Ebola response outlook 2015; citation_publication_date=2015; citation_id=CR43; citation_author=B Ki-moon; citation_author=D Nabarro
citation_journal_title=N Engl J Med; citation_title=Emergence of Zaire Ebola virus disease in Guinea; citation_author=S Baize, D Pannetier, L Oestereich, T Rieger, L Koivogui, N Magassouba, B Soropogui; citation_volume=371; citation_issue=15; citation_publication_date=2014; citation_pages=1418-25; citation_doi=10.1056/NEJMoa1404505; citation_id=CR44
Burd EM. Ebola virus: a clear and present danger. J Clin Microbiol. 2014. doi:
10.1128/JCM.03115-14
. JCM. 03115–14.
citation_journal_title=EMBO Mol Med; citation_title=Investigating the zoonotic origin of the West African Ebola epidemic; citation_author=A Marí Saéz, S Weiss, K Nowak, V Lapeyre, F Zimmermann, A Düx, HS Kühl; citation_volume=7; citation_issue=1; citation_publication_date=2015; citation_pages=17-23; citation_doi=10.15252/emmm.201404792; citation_id=CR46
How Many Ebola Patients Have Been Treated Outside of Africa?, The New York Times. 2014.
http://www.nytimes.com/interactive/2014/07/31/world/africa/ebola-virus-outbreak-qa.html
. Acccessed 5 Sept 2016.
Gulland A. Spanish authorities investigate how nurse contracted Ebola. BMJ. 2014;349:g6120. doi:
10.1136/bmj.g6120
.
McCarthy M. Texas healthcare worker is diagnosed with Ebola. BMJ. 2014;349:g6200. doi:
10.1136/bmj.g6200
.
Ebola in Texas. Texas Department of Health Services. 2015.
http://www.texasebola.org/
. Accessed 5 Sept 2016.
Situation Report - March 30th 2016. WHO.
http://apps.who.int/ebola/current-situation/ebola-situation-report-30-march-2016
. Accessed 5 Sept 2016.
Pushed to the Limit and Beyond: A Year into the Largest Ever Ebola Outbreak. 2015. Médecins Sans Frontières
http://www.msf.org/en/article/ebola-pushed-limit-and-beyond
. Accessed 5 Sept 2016.
Wright S, Hanna L, Malifert M. A wake-up call: lessons from Ebola for the World’s Health Systems. Save the children. 2015.
citation_journal_title=Science; citation_title=Reduced vaccination and the risk of measles and other childhood infections post-Ebola; citation_author=S Takahashi, C Jessica, E Metcalf, MJ Ferrari, WJ Moss, SA Truelove, AJ Tatem, BT Grenfell, J Lessler; citation_volume=347; citation_issue=6227; citation_publication_date=2015; citation_pages=1240-2; citation_doi=10.1126/science.aaa3438; citation_id=CR54
citation_journal_title=Nature; citation_title=Maternal health: Ebolas lasting legacy; citation_author=EC Hayden; citation_volume=519; citation_issue=7541; citation_publication_date=2015; citation_pages=24-6; citation_doi=10.1038/519024a; citation_id=CR55
citation_journal_title=Obstet Med; citation_title=Ebola viral disease and pregnancy; citation_author=BO Black, S Caluwaerts, J Achar; citation_volume=8; citation_issue=3; citation_publication_date=2015; citation_pages=108-13; citation_doi=10.1177/1753495X15597354; citation_id=CR56
citation_journal_title=Nature; citation_title=Ebola’s mental-health wounds linger in Africa; citation_author=S Reardon; citation_volume=519; citation_issue=7541; citation_publication_date=2015; citation_pages=13-4; citation_doi=10.1038/519013a; citation_id=CR57
citation_journal_title=JAMA; citation_title=The 2014 Ebola outbreak and mental health: current status and recommended response; citation_author=JM Shultz, F Baingana, Y Neria; citation_volume=313; citation_issue=6; citation_publication_date=2015; citation_pages=567-8; citation_doi=10.1001/jama.2014.17934; citation_id=CR58
Ki-moon B. United Nations General Assembly: Sixty-Ninth Session Agenda Item 124 Global Health and Foreign Policy. United Nations, Geneva Switzerland; 2015.
Gates, Bill. 2015. Bill Gates: The Ebola Crisis Was Terrible. But Next Time Could Be Much Worse. The New York Times.
http://www.nytimes.com/2015/03/18/opinion/bill-gates-the-ebola-crisis-was-terrible-but-next-time-could-be-much-worse.html
. Accessed 5 Sept 2016.
Berkley, Seth, and Jeremy Farrar. 2015. “Ebola: One Year On.” Wall Street Journal, March 18, sec. Opinion.
http://www.wsj.com/articles/seth-berkley-and-jeremy-farrar-ebolaone-year-on-1426709020
. Accessed 5 Sept 2016.
citation_journal_title=Science; citation_title=Beyond Ebola; citation_author=J Currie, B Grenfell, J Farrar; citation_volume=351; citation_issue=6275; citation_publication_date=2016; citation_pages=815-6; citation_doi=10.1126/science.aad8521; citation_id=CR62
citation_journal_title=J Autoimmun.; citation_title=The Zika outbreak of the 21st century; citation_author=C Chang, K Ortiz, A Ansari, ME Gershwin; citation_volume=68; citation_publication_date=2016; citation_pages=1-13; citation_doi=10.1016/j.jaut.2016.02.006; citation_id=CR63
citation_journal_title=Epidemiol Infect; citation_title=Seasonal influenza in the United States, France, and Australia: transmission and prospects for control; citation_author=G Chowell, MA Miller, C Viboud; citation_volume=136; citation_issue=06; citation_publication_date=2008; citation_pages=852-64; citation_doi=10.1017/S0950268807009144; citation_id=CR64
citation_journal_title=Am J Epidemiol; citation_title=Dynamic models of meningococcal carriage, disease, and the impact of Serogroup C conjugate vaccination; citation_author=CL Trotter, NJ Gay, W John Edmunds; citation_volume=162; citation_issue=1; citation_publication_date=2005; citation_pages=89-100; citation_doi=10.1093/aje/kwi160; citation_id=CR65
Anderson RM, May RM, Anderson B. Infectious diseases of humans: dynamics and control. Oxford: Oxford university press; 1992.
History and epidemiology of global smallpox eradication. 2014. Module of CDC and WHO course: Smallpox: Disease, Prevention, and Intervention; 2001.
https://stacks.cdc.gov/view/cdc/27929