Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

FEBS Letters - Tập 408 Số 1 - Trang 39-42 - 1997
Olivier Boss1, Sonia Samec2, Ariane Paoloni‐Giacobino3, Colette Rossier3, Abdul G. Dulloo2, Josiane Seydoux2, Patrick Muzzin1, Jean‐Paul Giacobino1
1Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland
2Department of Physiology, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland
3Department of Medical Genetics, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland

Tóm tắt

Brown adipose tissue (BAT) and skeletal muscle are important sites of nonshivering thermogenesis. The uncoupling protein‐1 (UCP1) is the main effector of nonshivering thermogenesis in BAT and the recently described ubiquitous UCP2 [1]has been implicated in energy balance. In an attempt to better understand the biochemical events underlying nonshivering thermogenesis in muscle, we screened a human skeletal muscle cDNA library and isolated three clones: UCP2, UCP3L and UCP3S. The novel UCP3 was 57% and 73% identical to human UCP1 and UCP2, respectively, highly skeletal muscle‐specific and its expression was unaffected by cold acclimation. This new member of the UCP family is a candidate protein for the modulation of the respiratory control in skeletal muscle.

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FEBS Letters

Tập 408 Số 1

39-42

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