Ultrasound molecular imaging with targeted microbubble contrast agents

Journal of Nuclear Cardiology - Tập 14 - Trang 876-884 - 2007
Alexander L. Klibanov1
1Cardiovascular Division, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville

Tóm tắt

Microbubbles have shown significant promise as molecular imaging agents for ultrasound contrast imaging in the detection of intravascular targets, such as inflammation, ischemia-reperfusion injury, ischemic memory, atherosclerotic plaque detection, and angiogenic vasculature (currently all in the animal-model setting). Combining these preparations with the widespread use of ultrasound imaging equipment and the increasing popularity of circulating nontargeted contrast agents, the success of targeted ultrasound contrast material could be achieved.

Tài liệu tham khảo

Leighton TG. The acoustic bubble. London: Academic Press, 1994.

Klibanov AL, Rasche PT, Hughes MS, Wojdyla JK, Galen KP, Wible JH, Jr, et al. Detection of individual microbubbles of ultrasound contrast agents: imaging of free-floating and targeted bubbles. Invest Radiol 2004;39:187–95.

Leong-Poi H, Kuliszewski MA, Lekas M, Sibbald M, Teichert-Kuliszewska K, Klibanov AL, et al. Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle. Circ Res 20;101:295–303.

Leong-Poi H, Christiansen J, Klibanov AL, Kaul S, Lindner JR. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation 2003;1:455–60.

Ellegala DB, Leong-Poi H, Carpenter JE, Klibanov AL, Kaul S, Shaffrey ME, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 2003;108:336–41.

Harris TD, Kalogeropoulos S, Nguyen T, Dwyer G, Edwards DS, Liu S, et al. Structure-activity relationships of In-III-and Tc-99m-labeled quinolin-4-one peptidomimetics as ligands for the vitronectin receptor: potential tumor imaging agents. Bioconjugate Chem 2006;17:1294–313.

Cho YK, Yang W, Harry BL, Klibanov AL, Hossack JA, et al. Dual-targeted contrast enhanced ultrasound imaging of atherosclerosis in apolipoprotein e gene knockout mice. Circulation 2006; 114:759.