Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

Journal of Pathology - Tập 155 Số 1 - Trang 9-15 - 1988
James Lowe1, Andy Blanchard2, Ken Morrell3, Graham Lennox3, Lindsay M. Reynolds2, Michael A. Billett2, Michael Landon2, R J Mayer2
1Department of Pathology, University Hospital, Queen's Medical Centre, Nottingham, U.K.
2Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, Clifton Boulevard, Nottingham NG7 2UH U.K.
3Department of Pathology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K.

Tóm tắt

AbstractPolyclonal antibodies were raised which have a high affinity for conjugated ubiquitin. Immunocytochemistry was performed on paraffin sections of tissues showing well‐characterized inclusion bodies. Ubiquitin was found as a component of the intermediate filament inclusion bodies characteristic of several major diseases including Lewy bodies of Parkinson's disease, Pick bodies of Pick's disease, Mallory bodies of alcoholic liver disease, cytoplasmic bodies of a specific myopathy, and Rosenthal fibres within astrocytes. Ubiquitin was also present in the three histological lesions characteristic of Alzheimer's disease. These observations suggest a fundamental role for ubiquitin in the formation of intermediate filament inclusion bodies in man, and have implications regarding the pathogenesis of these important diseases.

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Journal of Pathology

Tập 155 Số 1

9-15

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