Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Nature Medicine - Tập 22 Số 6 - Trang 586-597 - 2016
Veit Rothhammer1, Iván Mascanfroni1, Lukas Bunse1, Maisa C. Takenaka1, Jessica E. Kenison1, Lior Mayo1, Chun‐Cheih Chao1, Bonny Patel1, Raymond Yan1, Manon Blain2, Jorge I. Alvarez3, Hania Kébir4, Niroshana Anandasabapathy5, Guillermo Izquierdo6, Steffen Jung7, Nikolaus D. Obholzer1, Nathalie Pochet8, Clary B. Clish9, Marco Prinz10, Alexandre Prat4, Jack P. Antel2, Francisco J. Quintana1
1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
2Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
3Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania USA
4Neuroimmunology Research Lab, Center for Excellence in Neuromics CRCHUM, Université de Montréal, Montréal, Quebec, Canada
5Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
6Molecular Biology Service, University of Sevilla, Sevilla, Spain
7Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
8Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, Massachusetts, USA
9Metabolite Profiling Platform, Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA
10Institute of Neuropathology, University of Freiburg, Freiburg, Germany

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