Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

International Journal of Epidemiology - Tập 41 Số 1 - Trang 161-176 - 2012
Caroline L. Relton1, George Davey Smith1
1Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK and 2MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), University of Bristol, Bristol, UK

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Tài liệu tham khảo

10.1016/j.drudis.2011.04.007

10.1056/NEJMra0907175

10.1093/carcin/bgr087

10.1258/jrsm.2009.09k077

10.1007/s00439-007-0448-6

10.1038/nature08454

10.1038/nature07633

10.1371/journal.pmed.1000356

10.1016/B978-0-12-380866-0.60006-X

10.1016/S1474-4422(09)70262-5

Kaminsky Z Tochigi M Jia P . A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Mol Psychiatry. 2011; doi:10.1038/mp.2011.64 [Epub].

10.2337/db11-1039

10.2337/db10-0979

10.1186/1755-8794-3-33

10.1093/hmg/ddr253

10.1093/hmg/ddq561

10.1016/0160-9327(77)90005-9

10.1242/jeb.019752

10.1038/nature05913

10.1086/598822

Jablonka E Lamb MJ . Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life. Cambridge: MIT Press; 2005.

Ogbuanu IU Zhang H Karmaus W . Can we apply the Mendelian randomization methodology without considering epigenetic effects? Emerg Themes Epidemiol 2009;6:3.

10.1016/j.cell.2011.05.029

10.1007/s00335-008-9124-y

10.1073/pnas.0436776100

10.1038/nature09491

10.1055/s-0029-1237423

10.4161/epi.6.7.16537

10.1101/gr.106138.110

10.1016/j.ceb.2007.04.002

10.1074/jbc.R110.197061

10.1126/science.1108190

Matthews SG Phillips DI . Transgenerational inheritance of stress pathology. Exp Neurol 2011. doi:10.1016/j.expneurol.2011.01.009 [Epub].

Sinclair KD Karamitri A Gardner DS . Dietary regulation of developmental programming in ruminants: epigenetic modifications in the germline. Soc Reprod Fertil Suppl 2010;67:59-72.

10.1002/bies.201000015

Crepin M Dieu MC Lejeune S . Evidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility. Hum Mutat 2011;33:180-188.

10.1038/442882a

10.1016/j.cell.2010.12.008

10.1038/ijo.2008.100

10.1371/journal.pgen.1001380

10.1086/660911

10.1093/ije/dys016

Charlesworth D Charlesworth B . Not quite a revolution. The Guardian Review. 3 September 2011, p. 15.

Haldane J . Some principles of causal analysis in genetics. Erkenntnis 1936;6:346-57.

Lynch M . The rate of polygenic mutation. Genet Res 1988;51:137-48.

Francis R . Epigenetics: The Ultimate Mystery of Inheritance. New York: W.W. Norton & Company, Incorp; 2011.

Carey N . The Epigenetics Revolution: How Modern Biology is Rewriting Our Understanding of Genetics, Disease and Inheritance. London: Icon Books Ltd;; 2011.

10.1186/gb-2011-12-1-r10

10.4161/epi.5.7.12960

10.1038/nrg3000

10.1038/nrg2732

10.1289/ehp.1103423

10.1007/978-1-61779-316-5_11

10.1016/j.ajhg.2011.03.003

10.1200/JCO.2010.31.3577

10.1371/journal.pone.0008274

Kneip C Schmidt B Seegebarth A . SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma. J Thorac Oncol 2011. 6:1632–38.

10.1038/nature10166

10.1111/j.1742-7843.2007.00191.x

10.1093/ije/dyg070

10.1093/hmg/ddi267

10.1038/ng1589

10.1093/ije/29.4.722

10.1093/ije/dyh048

10.1002/sim.3034

10.1093/qjmed/hch025

10.1136/bmj.330.7499.1076

10.1371/journal.pmed.0050177

10.1371/journal.pmed.0040352

10.1016/S0140-6736(05)67485-5

10.1016/j.atherosclerosis.2007.02.002

10.1016/S0140-6736(05)67786-0

10.1161/01.ATV.0000160351.95181.d0

10.1093/ije/dyl041

10.1093/ije/dyl114

10.1001/jama.2009.801

10.1001/jama.2009.812

10.1056/NEJMoa0707402

10.1007/s11906-011-0242-7

10.1001/jama.2009.949

10.1161/HYPERTENSIONAHA.109.130005

10.1093/ije/dyp162

10.1056/NEJMoa0804381

10.1016/S0140-6736(11)60888-X

10.1016/S0168-9525(01)02310-1

10.1038/nature06014

Chen Y Zhu J Lum PY . Variations in DNA elucidate molecular networks that cause disease. Nature 2008;52:429-35.

10.1038/nature06758

10.1007/s00335-005-0175-z

10.1097/EDE.0b013e31821d0426

Wright MW Bruford EA . Naming 'junk': human non-protein coding RNA (ncRNA) gene nomenclature. Hum Genomics 2011;5:90-98.

10.1038/nature04674

10.1016/j.gde.2011.01.020

10.1126/scitranslmed.3001262

10.1007/s00428-009-0847-2

10.1073/pnas.0906183107

Cloud J . Why your DNA isn't your destiny. Time Magazine. 6 January 2010.

Harrell E . The Human Epigenome. Time Magazine. 8 October 2009.

10.1007/s10539-006-9033-y

10.1096/fj.07-8229com

10.1016/S0022-5193(89)80058-X

10.1371/journal.pgen.1001252

10.1002/hep.23572

10.1186/1756-8935-3-11

10.1161/CIRCGENETICS.110.958744

10.1371/journal.pgen.1000952

10.1016/j.ajhg.2010.02.005

10.1371/journal.pgen.1001316

10.1101/gr.104695.109

10.1371/journal.pone.0014040

10.1097/00001648-199203000-00013

10.1093/ije/31.1.163

10.1093/ije/31.1.166

10.1093/aje/kwr173

10.1093/ije/dyp334

10.1158/1055-9965.EPI-11-0496

10.1093/hmg/ddp388

10.1371/journal.pmed.0050052

10.1093/jnci/djr008

10.1126/science.1151710

10.1371/journal.pone.0014524

10.1038/ng.865

10.1038/nature09367

10.1038/ng.298

10.1038/nn.2270

10.1111/j.1365-2826.2008.01725.x

10.1371/journal.pone.0014739

10.1016/S0140-6736(03)12715-8

10.1101/gr.086181.108

10.1093/hmg/ddq376

10.2217/pme.11.14

10.1002/em.20590

10.1093/ije/dyr077

10.1038/ng.571

10.4161/epi.6.7.16500

10.1371/journal.pgen.1001307

10.1136/bmj.b1665

10.1359/jbmr.081109

10.1038/nature09270