Two “childhood” malignancies in an elderly individual: a case report and discussion
Tóm tắt
Rhabdomyosarcoma (RMS) is the most common soft-tissue tumor in childhood, but is extremely rare in elderly. We present a rare case of cardiac RMS, which developed 1 year after the diagnosis and management of acute lymphoblastic leukemia in a 68-year-old female. The occurrence of such phenomena is intriguing, especially in an individual without prior history of malignancy at a younger age. Through the review of the existing literature, we attempt to approach the pathogenesis and clinical manifestations of this rare clinical entity.
Tài liệu tham khảo
Gurney JG, et al. SEER pediatric monograph, soft tissue sarcomas, ICCC IX, National Cancer Institute, Bethesda. http://seer.cancer.gov/publications/childhood/softtissue.pdf (2009). Accessed 4 August 2009.
Pastore G, et al. Childhood soft tissue sarcomas incidence and survival in European children (1978–1997): report from the automated childhood cancer information system project. Eur J Cancer. 2006;42:2136–49.
Linker C, Damon L, Ries C, Navarro W. Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J Clin Oncol. 2002;20(10):2464–71.
Pappo AS, et al. Two consecutive phase II window trials of irinotecan alone or in combination with vincristine for the treatment of metastatic rhabdomyosarcoma: the children’s oncology group. J Clin Oncol. 2007;25(4):362–9.
Taylor PR, Reid MM, Proctor SJ. Acute lymphoblastic leukaemia in the elderly. Leuk Lymphoma. 1994;13(5–6):373–80.
Delannoy A, et al. Acute lymphoblastic leukemia in the elderly. Eur J Haematol. 1990;45(2):90–3.
Virgilio JF, et al. Acute lymphocytic leukemia (ALL) in elderly patients. Hematol Oncol. 1993;11(3):121–6.
Robak T. Acute lymphoblastic leukaemia in elderly patients: biological characteristics and therapeutic approaches. Drugs Aging. 2004;21(12):779–91.
Reynen K, Daniel WG. Malignant primary tumors of the heart. Z Kardiol. 1997;86(8):598–607.
Blondeau P. Primary cardiac tumors—French studies of 533 cases. Thorac Cardiovasc Surg. 1990;38(Suppl 2):192–5.
Simon JH, Paulino AC, Ritchie JM, Mayr NA, Buatti JM. Presentation, prognostic factors and patterns of failure in adult rhabdomyosarcoma. Sarcoma. 2003;7(1):1–7.
Hui KS, Green LK, Schmidt WA. Primary cardiac rhabdomyosarcoma: definition of a rare entity. Am J Cardiovasc Pathol. 1988;2(1):19–29.
Perchinsky MJ, Lichtenstein SV, Tyers GF. Primary cardiac tumors: forty years experience with 71 patients. Cancer. 1997;79(9):1809–15.
Burke A. Primary malignant cardiac tumors. Semin Diagn Pathol. 2008;25(1):39–46.
Camerieri A, Costa E, Scarano F, Colacino R. Primary cardiac rhabdomyosarcoma involving the mitral valve. G Ital Cardiol. 1992;22(9):1093–7.
Boice JD Jr, Curtis RE, Kleinerman RA, Flannery JT, Fraumeni JF Jr. Multiple primary cancers in connecticut, 1935–82. Yale J Biol Med. 1986;59(5):533–45.
Li FP, Fraumeni JF Jr. Soft-tissue sarcomas, breast cancer and other neoplasms: a familial syndrome? Ann Intern Med. 1969;71:747–52.
Ali R. Rhabdomyosarcoma of the perianal region presenting as acute leukemia. Ann Hematol. 2004;83(11):729–30.
Morandi S, Manna A, Sabattini E, Porcellini A. Rhabdomyosarcoma presenting as acute leukemia. J Pediatr Hematol Oncol. 1996;18(3):305–7.
Kahn DG. Rhabdomyosarcoma mimicking acute leukemia in an adult: report of a case with histologic, flow cytometric, cytogenetic, immunohistochemical, and ultrastructural studies. Arch Pathol Lab Med. 1998;122(4):375–8.
Merimsky O, et al. Multiple primary malignancies in association with soft tissue sarcomas. Cancer. 2001;91(7):1363–71.