Tumor formation by genetic mutations in the components of the Wnt signaling pathway

Cancer Science - Tập 94 Số 3 - Trang 225-229 - 2003
Akira Kikuchi1
1Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University.

Tóm tắt

The genetics of development and cancer have converged in the identification of intra‐ and extra‐cellular signaling pathways that are aberrantly regulated in cancer, and are also central to embryonic patterning. The Wnt signaling pathway has provided an outstanding example of this. The genes for β‐catenin, ARC, and Axin in the Wnt signaling pathway are often mutated in human cancers. In all such cases, the common denominator is the activation of gene transcription by β‐catenin. The resulting gene expression profile should provide a significant clue to the developmental mechanisms of cancers carrying defects in the Wnt signaling pathway. In this review, the functions of β‐catenin, APC and Axin, and the alterations of the three genes in human cancers are described. (Cancer Sci 2003; 94: 225–229)

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Tài liệu tham khảo

10.1146/annurev.cellbio.14.1.59

10.1101/gad.14.15.1837

10.1093/emboj/17.5.1371

10.1016/S0898-6568(99)00054-6

10.1016/S0092-8674(02)00685-2

10.1093/emboj/18.9.2401

10.1016/S0959-4388(00)00176-8

10.1093/emboj/21.10.2303

10.1126/science.2006419

10.1093/emboj/17.24.7151

10.1016/S1097-2765(01)00242-8

10.1016/S1097-2765(01)00241-6

10.1093/emboj/19.22.6121

10.1093/emboj/18.8.2208

10.1038/35094067

10.1126/science.289.5482.1194

10.1038/ncb779

10.1074/jbc.273.18.10823

Smith KJ, 1994, Wild‐type but not mutant APC associates with the microtubule cytoskeleton, Cancer Res, 54, 3672

Su LK, 1995, APC binds to the novel protein EB1, Cancer Res, 55, 2972

10.1126/science.272.5264.1020

10.1074/jbc.275.12.8369

Rubinfeld B, 1996, Binding of GSK3P to the APC‐β‐catenin complex and regulation of complex assembly, Science, 272, 1023, 10.1126/science.272.5264.1023

10.1038/sj.onc.1203359

10.1074/jbc.M003997200

Oshima H, 1997, Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice, Cancer Res, 57, 1644

10.1083/jcb.134.1.165

10.1083/jcb.148.3.505

Miyaki M, 1999, Frequent mutation of beta‐catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolypo‐sis colorectal cancer, Cancer Res, 59, 4506

10.1016/S0092-8674(00)80324-4

10.1017/S0016672300025702

10.1038/sj.onc.1202388

10.1128/MCB.19.6.4414

10.1074/jbc.M103555200

10.1083/jcb.200102074

Moline MM, 1999, Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo, Development, 126, 4375, 10.1242/dev.126.19.4375

10.1016/S1097-2765(01)00224-6

10.1038/nature01056

10.1038/73448

10.1128/MCB.18.5.2867

10.1126/science.280.5363.596