Truncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man

Digestive Diseases and Sciences - Tập 38 Số 4 - Trang 665-673 - 1993
André Wettergren1, Birgit Schjoldager1, Poul Erik Mortensen1, John Myhre1, John Christiansen1, Jens J. Holst1
1Departments of Surgical Gastroenterology D and Internal Medicine F, Glostrup County Hospital, Copenhagen, Denmark

Tóm tắt

Từ khóa


Tài liệu tham khảo

Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF: Preproglucagon gene expression in pancreas and intestine diversifies at the level of posttranslational processing. J Biol Chem 261:11880?11886, 1986

Novak U, Wilks A, Buell G, McEven S: Identical mRNA for preproglucagon in pancreas and the gut. Eur J Biochem 164:553?557, 1987

Ørskov C, Holst JJ, Knuhtsen S, Baldissera FGA, Poulsen SS, Nielsen OV: Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from the pig small intestine, but not pancreas. Endocrinology 119:1467?1475, 1986

Holst JJ: Enteroglucagon. Adv Metab Dis 11:392?419, 1988

Ørskov C, Holst JJ, Poulsen SS, Kirkegaard P: Pancreatic and intestinal processing of proglucagon in man. Diabetologia 30:874?881, 1987

Holst JJ, Ørskov C, Nielsen OV, Schwartz TW: Truncated glucagon-like 1, an insulin-releasing hormone from distal gut. FEBS Lett 211:169?174, 1987

Ørskov C, Bersani M, Johnsen AH, Højrup P, Holst JJ: Complete sequence of glucagon-like peptide (GLP-1) from human and pig small intestine. J Biol Chem 264:12826?12829 1989

Kreyman B, Ghatei MA, Williams G, Bloom SR: Glucagon-like peptide 1 7?36: A physiological incretin in man. Lancet 2:1300?1304, 1987

Mojsov S, Weir GO, Habener JF: Insulinotropin: Glucagon-like peptide 1 (7?37) coencoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79:616?619, 1987

Ørskov C, Holst JJ, Nielsen OV: Effect of truncated glucagon-like peptide-1 (proglucagon 78?107-amide) on endocrine secretion from pig pancreas, antrum, and stomach. Endocrinology 123:2009?2013, 1988

Christiansen J, Holst JJ, Kalaja E: Inhibition of gastric acid in man by exogenous and endogenous pancreatic glucagon. Gastroenterology 70:688?692, 1976

Schjoldager BTG, Baldissera FGA, Mortensen PE, Holst JJ, Christiansen J: Oxyntomodulin: A potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man. Eur J Clin Invest 18:499?503, 1988

Schjoldager BTG, Mortensen PE, Myhren J, Christiansen J, Holst JJ: Oxyntomodulin from distal gut: Role in regulation of gastric and pancreatic function. Dig Dis Sci 34:1411?1419, 1989

Schjoldager BTG, Mortensen PE, Christiansen J, Ørskov C, Holst JJ: GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of the human proglucagon, inhibit gastric acid secretion in humans. Dig Dis Sci 34:703?708, 1989

O'Halloran DJ, Nikou GC, Kreyman B, Ghatei MA, Bloom SR: Glucagon-like peptide-1 (7?36)-NH2: A physiological inhibitor of the gastric acid secretion in man. J Endocrinol 126:169?173, 1990

Ørskov C, Holst JJ: Radioimmunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2). Scand J Clin Lab Invest 47:165?174, 1987

Schjoldager BTG, Lawaetz O, Christiansen J: Effect of pancreatic glucagon and its 1?21 fragment on gastric emptying in man. Scand J Gastroenterol 23:726?730, 1988

Lawaetz O, Ohlsen HP, Andreasen R: Evaluation of gastric emptying by a single isotope technique. Scand J Gastroenterol 16:737?748, 1981

Go VLW, Hofmann AF, Summerskill WHJ: Simultaneous measurements of total pancreatic, biliary and gastric outputs in man using a perfusion technic. Gastroenterology 58:321?328, 1970

Dimagno EP: Alternations and consequences of interdigestive and poststimulatory human exocrine pancreatic secretion in health and disease. Scand J Gastroenterol 12(suppl 87): 69, 1983

Worning H, Müllertz S: pH and pancreatic enzymes in the human duodenum during digestion of a standard meal. Scand J Gastroenterol 1:268?283, 1966

Ørskov C, Jeppesen J, Madsbad S, Holst JJ: Proglucagon products in plasma of non-insulindependent diabetics and nondiabetic controls in the fasting state and following oral glucose and intravenous arginine. J Clin Invest 87:415?423, 1991

Holst JJ, Creutzfeldt M, Holm G, Jensen E, Poulsen D, Sparsø B, Schmidt A: Persistent glucagonemia after pancreatectomy in pigs. Diabete Metab 4:75?79, 1978

Stadil F, Refeldt JF: Determination of gastrin in serum. Scand J Gastrenterol 8:101, 1973

Albanc JDM, Ekins RP, Maritz G, Turner RC: A sensitive precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free serum hormone moieties. Acta Endocrinol (Kbh) 70:487?509, 1972

Widdonson GM, Penton JR: Determination of serum and plasma glucose on ?autoanalyzer II? by use of hexokinase reaction. Clin Chem 18:299?300, 1972

Malagelada J-R, Longstreth GF, Summerskill WHJ, Go VLW: Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterology 70:203?210, 1976

Debas HT: Peripheral regulation of gastric secretion.In Physiology of the Gastrointestinal Tract, 2nd ed. LR Johnson (ed). New York, Raven Press, 1987, pp 931?945

Solomon TE: Control of exocrine pancreatic secretion.In Physiology of the Gastrointestinal Tract, 2nd ed. LR Johnson (ed). New York, Raven Press, 1987, pp 1173?1208

Kosaka T, Lim RKS: Demonstration of the humoral agent in fat inhibition of gastric secretion. Proc Soc Exp Biol Med 27:890?891, 1980

Harper AA, Hood AJC, Mushens J, Smy JR: Pancreotone, an, inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa. J Physiol (London) 292:455?467, 1979

Olsen PS, Pedersen JH, Kirkegaard P, Been H, Stadil F: Neurotensin induced inhibition of acid secretion in duodenal ulcer patients before and after vagotomy. Gut 25:481?484, 1984

Mogard MH, Maxwell VE, Sytnik B, Walsh JH: Regulation of gastric acid secretion by neurotensin in man: Evidence against a hormonal role. J Clin Invest 80:1064?1067, 1987

Adrian TE, Savage AP, Sagor GR, Allen JM, Bacarese-Hamilton AJ, Tatemoto K, Polak JM, Bloom SR: Effect of peptide YY on gastric, pancreatic and biliary functions in humans. Gastroenterology 89:494?499, 1985

Luis F, Gomez G, Fujinura M, Greeley GH Jr, Thompson JC: Peptide YY inhibits nutrient, hormonal and vagally stimulated pancreatic exocrine secretion. Pancreas 2:454?462, 1987

Böttcher G, Sjölund K, Ekblad E, Håkanson R, Schwartz T, Sundler F: Coexistence of PYY and glicentin immunoreactivity in endocrine cells of the gut. Regul Pept 8:261?266, 1984

Kirkegaard P, Loud FB, Moody AJ, Holst JJ, Christiansen J: Gut GLI inhibits gastric acid secretion in the rat. Nature 297:156?157, 1982

Miholic J, Ørskov C, Holst JJ, Kotserke J, Meyer HJ: Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy. Dig Dis Sci 36:1361?1370, 1991

Holst JJ, Rasmussen TN, Harling H, Schmidt P: Effect of intestinal inhibitory peptides on vagally induced secretion from isolated perfused porcine pancreas. Pancreas (in press)

Ørskov C: Glucagon-like peptide-1. Diabetologia 35:701?711, 1992

Gutniak M, Ørskov C, Holst JJ, Ahren B, Efendic S: Antidiabetogenic effect of glucagon-like peptide-1 (7?36)amide in normal subjects and patients with diabetes, mellitus. N Engl J Med 326:1316?1322, 1992