Trophoblast Induces Monocyte Differentiation Into CD 14+/CD 16+ Macrophages
Tóm tắt
During early pregnancy, macrophages and trophoblast come into close contact during placenta development, and regulated cross talk between these cellular compartments is crucial for maintaining a healthy pregnancy. As trophoblast cells constitutively secrete many chemokines and cytokines, we hypothesize that trophoblast‐secreted factors can differentiate monocytes into a decidual phenotype. In this study, we describe a unique macrophage phenotype, following monocytes’ exposure to trophoblast‐soluble factors.
Peripheral blood monocytes were treated with or without conditioned media (
Monocytes exposed to trophoblast factors undergo morphologic changes characterized by a gain in size and complexity and acquire a unique phenotype characterized by gain of
We demonstrate that trophoblast‐secreted factors can induce monocyte differentiation into a unique macrophage phenotype. These findings suggest that the microenvironment of the placenta can modulate the phenotype of macrophages present at the decidua.
Từ khóa
Tài liệu tham khảo
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