Triple tSMS system (“SHIN jiba”) for non-invasive deep brain stimulation: a validation study in healthy subjects

Journal of NeuroEngineering and Rehabilitation - Tập 19 - Trang 1-7 - 2022
Sumiya Shibata1,2, Tatsunori Watanabe3,4, Takuya Matsumoto4, Keisuke Yunoki4, Takayuki Horinouchi4, Hikari Kirimoto4, Jianxu Zhang5, Hen Wang6, Jinglong Wu5,7, Hideaki Onishi1,2, Tatsuya Mima8
1Department of Physical Therapy, Niigata University of Health and Welfare, Niigata, Japan
2Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
3Faculty of Health Sciences, Aomori University of Health and Welfare, Aomori, Japan
4Department of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
5School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China
6Qingdao Medical College, Qingdao University, Qingdao, China
7Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan
8The Graduate School of Core Ethics and Frontier Sciences, Ritsumeikan University, Kyoto, Japan

Tóm tắt

Transcranial static magnetic field stimulation (tSMS) using a small and strong neodymium (NdFeB) magnet can temporarily suppress brain functions below the magnet. It is a promising non-invasive brain stimulation modality because of its competitive advantages such as safety, simplicity, and low-cost. However, current tSMS is insufficient to effectively stimulate deep brain areas due to attenuation of the magnetic field with the distance from the magnet. The aim of this study was to develop a brand-new tSMS system for non-invasive deep brain stimulation. We designed and fabricated a triple tSMS system with three cylindrical NdFeB magnets placed close to each other. We compared the strength of magnetic field produced by the triple tSMS system with that by the current tSMS. Furthermore, to confirm its function, we stimulated the primary motor area in 17 healthy subjects with the triple tSMS for 20 min and assessed the cortical excitability using the motor evoked potential (MEP) obtained by transcranial magnetic stimulation. Our triple tSMS system produced the magnetic field sufficient for neuromodulation up to 80 mm depth from the magnet surface, which was 30 mm deeper than the current tSMS system. In the stimulation experiment, the triple tSMS significantly reduced the MEP amplitude, demonstrating a successful inhibition of the M1 excitability in healthy subjects. Our triple tSMS system has an ability to produce an effective magnetic field in deep areas and to modulate the brain functions. It can be used for non-invasive deep brain stimulation.

Tài liệu tham khảo

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Journal of NeuroEngineering and Rehabilitation

Tập 19

1-7

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