Triclosan: environmental exposure, toxicity and mechanisms of action

Journal of Applied Toxicology - Tập 31 Số 4 - Trang 285-311 - 2011
Andrea B. Dann1, Alice Hontela1
1Department of Biological Sciences Alberta Water and Environmental Science Bldg, 4401 University Dr. W. University of Lethbridge Lethbridge Alberta Canada T1K 3M4

Tóm tắt

ABSTRACTTriclosan [5‐chloro‐2‐(2,4‐dichlorophenoxy)phenol; TCS] is a broad spectrum antibacterial agent used in personal care, veterinary, industrial and household products. TCS is commonly detected in aquatic ecosystems, as it is only partially removed during the wastewater treatment process. Sorption, biodegradation and photolytic degradation mitigate the availability of TCS to aquatic biota; however the by‐products such as methyltriclosan and other chlorinated phenols may be more resistant to degradation and have higher toxicity than the parent compound. The continuous exposure of aquatic organisms to TCS, coupled with its bioaccumulation potential, have led to detectable levels of the antimicrobial in a number of aquatic species. TCS has been also detected in breast milk, urine and plasma, with levels of TCS in the blood correlating with consumer use patterns of the antimicrobial. Mammalian systemic toxicity studies indicate that TCS is neither acutely toxic, mutagenic, carcinogenic, nor a developmental toxicant. Recently, however, concern has been raised over TCS's potential for endocrine disruption, as the antimicrobial has been shown to disrupt thyroid hormone homeostasis and possibly the reproductive axis. Moreover, there is strong evidence that aquatic species such as algae, invertebrates and certain types of fish are much more sensitive to TCS than mammals. TCS is highly toxic to algae and exerts reproductive and developmental effects in some fish. The potential for endocrine disruption and antibiotic cross‐resistance highlights the importance of the judicious use of TCS, whereby the use of TCS should be limited to applications where it has been shown to be effective. Copyright © 2011 John Wiley & Sons, Ltd.

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Tài liệu tham khảo

10.1016/S0045-6535(01)00255-7

10.1016/S0003-2670(03)00040-0

10.1289/ehp.11200

10.1086/519255

10.1016/j.scitotenv.2006.08.007

10.1016/j.scitotenv.2007.12.006

10.1111/j.1742-7843.2009.00455.x

10.1016/j.chemosphere.2006.07.010

10.1021/es030068p

10.1016/0045-6535(89)90306-8

10.1016/j.jhazmat.2010.03.056

10.1016/j.jhazmat.2005.03.012

10.1016/j.marpolbul.2009.05.005

10.1016/S0043-1354(03)00335-X

10.1007/s00244-004-0155-4

10.1016/S0196-6553(96)90017-6

10.1016/j.aquatox.2008.11.008

10.1016/j.cbpc.2009.02.005

10.1016/0300-483X(75)90006-2

10.1080/10807030701341209

Boehmer W, 2004, Retrospective monitoring of Triclosan and methyl‐triclosan in fish: results from the German environmental specimen bank, Organohalogen Compd., 66, 1516

10.1021/es052088s

10.1897/08-490.1

10.1289/ehp.10768

10.1002/pts.871

10.1016/j.cbpc.2007.02.002

10.1007/s00216-005-0116-4

10.1016/j.chroma.2008.02.064

10.1897/IEAM_2007-022.1

10.1111/j.1752-1688.2008.00284.x

10.1016/j.taap.2007.03.015

10.1016/0041-008X(77)90191-0

10.1016/j.chroma.2007.07.024

10.1046/j.1365-2621.2003.00657.x

CIBA 1998.Brochure no. 2521: IRGASAN DP 300/IRGA‐CARE MP: Toxicological and ecological data/Official registration.

10.1016/j.jhazmat.2005.03.002

10.1046/j.1365-2672.2003.02022.x

10.1897/07-374.1

10.1016/j.chemosphere.2006.12.027

10.1067/mic.2003.49

10.1016/j.etap.2007.04.008

10.1034/j.1600-051X.2003.20030.x

10.4315/0362-028X-62.5.474

10.1016/j.fct.2006.08.009

10.1007/s00244-007-9032-2

10.1002/tox.20327

DeSalva SJ, 1989, Triclosan: a safety profile, Am. J. Dent., 2, 185

10.1007/s00216-007-1807-9

10.1897/07-354R.1

FahrigR.1978.The effects of Irgasan DP 300 in the “Mammalian Spot Test” anin vivomethod for the detection of genetic alterations in somatic cells of mice. June 22. Zentrallaboratorium fur mutagenate‐sprufung der Deutschan Forschungs‐geneinshaf.

10.1016/j.envpol.2009.04.002

10.1021/es062227l

10.1016/S0141-1136(00)00080-5

10.1093/toxsci/kfp280

10.1002/tox.20017

10.1897/IEAM_2009-071.1

10.1177/0040517507082332

10.1002/jat.1316

10.1089/10962960260496343

10.1111/j.1469-0691.2007.01800.x

10.1111/j.1365-2125.1987.tb03094.x

10.1021/es051952d

10.14219/jada.archive.2006.0110

10.1021/es049071e

10.1016/0045-6535(96)00169-5

10.1016/S0045-6535(97)00464-5

10.1016/j.chemosphere.2006.04.066

10.1021/es049750p

10.1897/06-326R.1

10.1007/s002440010298

Imazato S, 1995, Antibacterial effect of composite incorporating triclosan against Streptococcus mutans, J. Osaka Univ. Dent. Sch., 35, 5

10.1016/j.aquatox.2003.12.005

10.1016/S0169-409X(03)00034-6

10.1016/j.taap.2005.03.015

10.1016/j.envint.2009.02.004

10.1002/jbm.a.31759

10.1080/004982597240271

Jirasripongpun K, 2008, Risk assessment of triclosan using animal cell lines, Kasetsart J. (Nat. Sci.), 42, 353

10.1067/mic.2000.102378

10.1093/jac/dkh196

10.1067/mic.2001.113229

10.1039/b306355k

10.1016/S0021-9673(01)94418-8

10.1007/BF01055832

10.1007/BF00226000

10.2131/jts.34.227

10.1021/es702304c

10.1021/es011055j

10.1016/j.tox.2008.06.012

10.1016/j.reprotox.2008.12.002

10.1016/S1010-6030(03)00103-5

10.1897/04-243R.1

Lee HB, 2002, Organic contaminants in Canadian municipal sewage sludge. Part I. Toxic or endocrine‐disrupting phenolic compounds, Water Qual. Res. J. Can., 37, 681, 10.2166/wqrj.2002.046

10.1016/j.scitotenv.2008.11.009

10.1038/18803

Lin YJ, 2000, Buccal absorption of triclosan following topical mouthrinse application, Am. J. Dent., 13, 215

10.1021/es0114254

10.1016/j.scitotenv.2006.03.021

10.1016/j.ecoenv.2008.06.009

10.1021/es051380x

10.1007/s00216-004-3047-6

10.1016/j.chemosphere.2009.10.043

10.1124/dmd.30.7.795

10.1897/IEAM_2009-072.1

Lyman FL, 1969, Toxicology of 2,4,4′‐Trichloro‐2′‐hydroxy‐diphenyl ether, Industr. Med. Surg., 38, 45

10.1002/ieam.73

10.1248/bpb.28.1748

10.1002/etc.5620210701

10.1038/28970

10.1016/j.aca.2004.05.050

10.1021/es702882g

10.1007/BF01607490

10.1016/j.chroma.2005.05.059

10.1016/j.chemosphere.2003.08.002

10.1016/S0278-6915(99)00164-7

10.1021/es7030856

10.2166/wst.2010.100

Nassef M, 2009, Pharmaceuticals and personal care products toxicity to Japanese medaka fish (Oryzias latipes), J. Fac. Agric. Kyushu Univ., 54, 407, 10.5109/16123

10.1016/j.chemosphere.2010.02.002

10.1016/j.toxlet.2005.06.004

10.1016/j.chemosphere.2005.04.017

Norris DO, 2006, Endocrine Disruption: Biological Basis for Health Effects in Wildlife and Humans

10.1007/s11356-009-0119-3

10.1248/jhs1956.41.212

10.1002/etc.5620210703

10.1016/j.cbpc.2010.04.009

10.1080/15287390902769428

10.1093/toxsci/kfp271

10.1128/AAC.00615-09

10.1897/08-561.1

10.1002/etc.150

10.1111/j.1469-0691.2007.01802.x

10.1002/etc.5620211130

10.1897/08-250.1

10.3109/10408441003667514

10.1111/j.1600-051X.1997.tb01205.x

10.1021/es048943

10.1016/S1473-3099(03)00833-8

10.1093/jac/dkh171

10.1016/0165-1218(80)90142-1

10.1016/S0043-1354(03)00164-7

10.1016/j.scitotenv.2009.04.027

10.1124/dmd.105.004648

10.1007/s00216-006-0311-y

10.1080/15287390600631706

10.1021/tx9800046

10.1111/j.1574-6968.2001.tb10772.x

Servos MR, 2007, The presence of selected pharmaceuticals and the antimicrobial triclosan in drinking water in Ontario, Canada, Water Qual. Res. J. Can., 42, 130, 10.2166/wqrj.2007.016

Siddiqui WH, 1979, Pharmacokinetics of triclosan in rat after intravenous and intravaginal administration, J. Environ. Pathol. Toxicol., 2, 861

10.1021/es025750i

10.1007/s10646-004-1352-7

10.1034/j.1600-051X.2002.291101.x

Swedish Chemical Agency.2001.Iniative against antibacterial additives in consumer products. Available from:http://www.kemi.se/upload/Trycksaker/Pdf/Antibaktrapport_2001.pdf

Tatarazako N, 2004, Effects of triclosan on various aquatic organisms, Environ. Sci., 11, 133

10.1021/es025647t

10.1038/nm1184

10.3109/00498257909038708

10.1021/es0506410

Broek AMWT, 2008, A review of the current literature on management of halitosis, Oral Dis., 14, 30, 10.1111/j.1601-0825.2006.01350.x

10.1016/j.aquatox.2006.08.010

10.1080/02652030110104852

10.1897/08-224.1

10.1124/dmd.104.000273

10.1289/ehp.9488

10.1089/mdr.2006.12.83

10.1016/j.envint.2006.09.008

10.1016/j.envpol.2007.02.013

10.1016/j.polymer.2005.12.009

10.1093/toxsci/kfn225

10.1046/j.0909-8836.1998.eos106204.x

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Journal of Applied Toxicology

Tập 31 Số 4

285-311

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