Trichosanthes dioica Roxb.: A vegetable with diverse pharmacological properties

Payel, 2015, Inter-genus variation analysis in few members of Cucurbitaceae based on ISSR markers, Biotechnol. Biotechnol. Equip., 29, 882, 10.1080/13102818.2015.1052760 Schaefer, 2018, Cucurbitaceae, vol. 10, 112 Kalwij, 2012, Review of ‘The Plant List, a working list of all plant species’, J. Veg. Sci., 23, 998, 10.1111/j.1654-1103.2012.01407.x Joppa, 2013, Achieving the convention on biological diversity’s goals for plant conservation, Science, 341, 1100, 10.1126/science.1241706 van Kleunen, 2015, Global exchange and accumulation of non-native plants, Nature, 525, 100, 10.1038/nature14910 Jeffrey, 1980, A review of the Cucurbitaceae, Bot. J. Linn. Soc., 81, 233, 10.1111/j.1095-8339.1980.tb01676.x Kumar, 2012, Trichosanthes dioica Roxb.: an overview, Pharmacogn. Rev., 6, 61, 10.4103/0973-7847.95886 Payel, 2015, Inter-genus variation analysis in few members of Cucurbitaceae based on ISSR markers, Biotechnol. Biotechnol. Equipment, 29, 882, 10.1080/13102818.2015.1052760 Christenhusz, 2016, The number of known plants species in the world and its annual increase, Phytotaxa, 261, 201, 10.11646/phytotaxa.261.3.1 Ghani, 2003 Kumar, 2011, Pointed Gourd: Botany and Horticulture, 203 Singh, 1999, 397 Rai, 2008, glycemic properties of trichosanthes dioica leaves, Pharmaceut. Biol., 46, 894, 10.1080/13880200802370167 Mythili, 1999, Micropropagation of pointed gourd (Trichosanthes dioica Roxb.), Sci. Horticult., 79, 87, 10.1016/S0304-4238(98)00201-5 Nayak, 2016, Effect of integrated nutrient management on productivity and profitability of pointed gourd (Trichosanthes dioica Roxb.), J. Crop Weed, 12, 25 Renner, 2013, The Cucurbitaceae of India: Accepted names, synonyms, geographic distribution, and information on images and DNA sequences, PhytoKeys, 53, 10.3897/phytokeys.20.3948 Mehta, 2012, Trichosanthes dioica (roxb.): a review on pharmacological update, Inventi Impact − Planta Activa, 12, 187 Alom, 2013, Performance of different crop species with pointed gourd (Trichosanthes dioica Roxb.), Bangladesh J. Agric. Res., 38, 523, 10.3329/bjar.v38i3.16979 Mishra, 2003 Nadkarni, 1994 Sen, 2008, Ethnomedicinal plants used by the tribals of Bargarh district to cure diarrhoea and dysentery, Ind. J. Tradit. Knowl., 7, 425 Saxena, 1995, A new steroidal saponin from Trichosanthes dioica (Roxb.), Asian J. Chem., 7, 490 Khare, 2004 Sarkar, 2017, Sex-oriented research on dioecious crops of Indian subcontinent: an updated review, 3 Biotech, 7, 93, 10.1007/s13205-017-0723-8 Khare, 2008 Ghosh, 2003, Herbal folk remedies of Bankura and Medinipur districts, West Bengal, Ind. J. Tradit. Knowl., 2, 393 Akhter, 2008, A review on the use of non-timber forest products in beauty-care in Bangladesh, J. For. Res., 19, 72, 10.1007/s11676-008-0014-7 Tumpa, 2014, Ethnomedicinal uses of herbs by indigenous medicine practitioners of Jhenaidah district, Bangladesh, J. Pharmacogn. Phytochem., 3, 23 Bhattacharya, 2010, Evaluation of in vitro cytotoxic effect of Trichosanthes dioica root, Pharmacogn. Res., 2, 355, 10.4103/0974-8490.75454 Sharmila, 2007, Cholesterol lowering activity of the aqueous fruit extract of Trichosanthes dioica Roxb. in normal and streptozotocin diabetic rats, J. Clin. Diagn. Res., 1, 561 Bhattacharya, 2009, In vitro effects of Trichosanthes dioica leaves on annelids and nematodes, Pharmacologyonline, 5, 242 Bhattacharya, 2012, Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents, Nat. Prod. Res., 26, 2348, 10.1080/14786419.2012.656111 Bhattacharya, 2012, Exploration of anti-nociceptive and locomotor effects of Trichosanthes dioica root extracts in Swiss albino mice, Asian Pac. J. Trop. Biomed., 2, S224, 10.1016/S2221-1691(12)60164-6 Bhattacharya, 2011, Trichosanthes dioica root extract induces tumor proliferation and attenuation of antioxidant system in albino mice bearing Ehrlich ascites carcinoma, Interdiscipl. Toxicol., 4, 184, 10.2478/v10102-011-0028-4 Sharma, 1988, Effect of raw deseeded fruit powder of Trichosanthes dioica (Roxb) on blood sugar serum cholesterol, high density lipo-protein, phospholipid and triglyceride levels in the normal albino rabbits, Ind. J. Physiol. Pharmacol., 32, 161 Rai, 2008, Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats, Ind. J. Clin. Biochem., 23, 387, 10.1007/s12291-008-0085-4 Rai, 2010, The Glycemic elemental Profile of Trichosanthes dioica: a LIBS-Based Study, Food Biophys., 5, 17, 10.1007/s11483-009-9139-2 Rai, 2013, A Scientific validation of antihyperglycemic and antihyperlipidemic attributes of Trichosanthes dioica, ISRN Pharmacol., 2013, 473059, 10.1155/2013/473059 Rai, 2008, Antihyperglycemic profile of Trichosanthes dioica. Seeds in experimental models, Pharmaceut. Biol., 46, 360, 10.1080/13880200801888011 Adiga, 2010, Hypoglycemic effect of aqueous extract of Trichosanthes dioica in normal and diabetic rats, Int. J. Diab. Dev. Countries, 30, 38, 10.4103/0973-3930.60011 Sharma, 1988, Preliminary observations on serum biochemical parameters of albino rabbits fed on seeds of Trichosanthes dioica (Roxb), Ind. J. Med. Res., 87, 398 Sharma, 1990, Biochemical evaluation of feeding Trichosanthes dioica seeds in normal and mild diabetic human subjects in relation to lipid profile, Ind. J. Physiol. Pharmacol., 34, 146 Bhattacharya, 2012, The triterpenoid fraction from Trichosanthes dioica root exhibits antiproliferative activity against Ehrlich ascites carcinoma in albino mice: involvement of possible antioxidant role, J. Exp. Therap. Oncol., 9, 281 Bhattacharya, 2011, Antitumor efficacy and amelioration of oxidative stress by Trichosanthes dioica root against Ehrlich ascites carcinoma in mice, Pharmaceut. Biol., 49, 927, 10.3109/13880209.2011.557080 Bhattacharya, 2012, Trichosanthes dioica fruit ameliorates experimentally induced arsenic toxicity in male albino rats through the alleviation of oxidative stress, Biol. Trace Element Res., 148, 232, 10.1007/s12011-012-9363-3 Bhattacharya, 2013, Trichosanthes dioica fruit extract ameliorates arsenic-induced brain toxicity in male albino rats, J. Environ. Pathol. Toxicol. Oncol., 32, 141, 10.1615/JEnvironPatholToxicolOncol.2013007557 Bhattacharya, 2014, Arsenic induced myocardial toxicity in rats: alleviative effect of Trichosanthes dioica fruit, Sci. World J., 11, 248 Bhattacharya, 2012, Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats, Environ. Toxicol. Pharmacol., 33, 394, 10.1016/j.etap.2012.02.003 Bhattacharya, 2013, Trichosanthes dioica root alleviates arsenic induced myocardial toxicity in rats, J. Environ. Pathol. Toxicol. Oncol., 32, 251, 10.1615/JEnvironPatholToxicolOncol.2013008541 Alam, 2011, Antioxidant, anti-inflammatory and anti-pyretic activities of Trichosanthes dioica Roxb. fruits, J. Pharmacol. Toxicol., 6, 440, 10.3923/jpt.2011.440.453 Bhattacharya, 2013, The triterpenoid fraction from Trichosanthes dioica root suppresses experimentally induced inflammatory ascites in rats, Pharmaceut. Biol., 51, 1477, 10.3109/13880209.2013.795176 Kharbanda, 2015, Ameliorative effects of Trichosanthes dioica Extract in suppressing inflammatory mediators and attenuating oxidative stress, Planta medica, 81, 348, 10.1055/s-0035-1545726 Akter, 2011, Antioxidant, antidiarrhoeal and cytotoxic properties of aerial parts of Trichosanthes dioica Roxb, Am. J. Food. Nutr, 1, 95, 10.5251/ajfn.2011.1.3.95.101 Bhattacharya, 2012, Chemopreventive property of Trichosanthes dioica root against 3-methylcholanthrene-induced carcinogenesis in albino mice, J. Environ. Pathol. Toxicol. Oncol., 31, 109, 10.1615/JEnvironPatholToxicolOncol.v31.i2.30 Bhattacharya, 2012, Evaluation of antimitotic and genotoxic effects of the triterpenoid enriched extract from Trichosanthes dioica root, Am.-Eur. J. Toxicol. Sci., 4, 20 Ghaisas, 2008 Bhadoriyal, 2012, Immunomodulatory effect of Tricosanthes Dioica Roxb, Asian Pac. J. Trop. Biomed., 2, S985, 10.1016/S2221-1691(12)60348-7 Bhattacharya, 2012, Trichosanthes dioica root possesses stimulant laxative activity in mice, Nat. Prod. Res., 26, 952, 10.1080/14786419.2010.535161 Bhattacharya, 2012, Gastrointestinal effects of triterpenoid enriched extract of Trichosanthes dioica root in albino mice, Orient. Pharm. Exp. Med., 12, 113, 10.1007/s13596-011-0049-8 Shivhare, 2010, Wound healing potential of methanolic extract of Trichosanthes dioica Roxb (fruits) in rats, J. Ethnopharmacol., 127, 614, 10.1016/j.jep.2009.12.015 Li, 2010, Possible mechanisms of trichosanthin-induced apoptosis of tumor cells, Anatom. Rec. (Hoboken, N.J.: 2007), 293, 986, 10.1002/ar.21142 Sha, 2013, Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review, Cancer Chemother. Pharmacol., 71, 1387, 10.1007/s00280-013-2096-y Sharma, 2009, Antioxidant activities and phenolic contents of the aqueous extracts of some Indian medicinal plants, J. Med. Plants Res., 3, 944 Yadav, 2016, Antioxidant activity of various extracts of selected gourd vegetables, J. Food Sci. Technol., 53, 1823, 10.1007/s13197-015-1886-0 Harit, 1996, Antifungal activity of the unsaponifiable fraction of the fixed oils of trichosanthes seeds, Asian J. Chem., 8, 180 Bhattacharya, 2013, Neuropharmacological properties of Trichosanthes dioica root, Chin. J. Nat. Med., 11, 158 Bhattacharya, 2010, Paralytic and lethal effects of Trichosanthes dioica root extracts in experimental worms, Pharmaceut. Biol., 48, 960, 10.3109/13880200903311144 Chopra, 1956 Wong, 2014, Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential, Chin. Med., 9, 19, 10.1186/1749-8546-9-19 Kabir, 2000, The novel peptide composition of the seeds of Trichosanthes dioica Roxb, Cytobios, 103, 121 Sultan, 2004, Purification, physicochemical characterization, saccharide specificity, and chemical modification of a Gal/GalNAc specific lectin from the seeds of Trichosanthes dioica, Arch. Biochem. Biophys., 432, 212, 10.1016/j.abb.2004.09.016 Akihisa, 1986, Sterol compositions of seeds and mature plants of family cucurbitaceae, J. Am. Oil Chem. Soc., 63, 653, 10.1007/BF02638231 Akihisa, 1988, Compositions of triterpene alcohols of seeds and mature plants of family cucurbitaceae, J. Am. Oil Chem. Soc., 65, 607, 10.1007/BF02540688 Akihisa, 1997, 7-oxodihydrokarounidol-3-benzoate and other triterpenes from the seeds of cucurbitaceae, Phytochemistry, 46, 1261 Solomon, 2014, Determination of Cucurbitacin B in Trichosanthes dioica Roxb by HPTLC, Pharmacogn. Commun., 4, 8, 10.5530/pc.2014.2.3 Baitha, 2003, Silica gel chromatographic study of phenolic compounds in some cultivated cucurbits, Himalayan J. Sci., 1, 123, 10.3126/hjs.v1i2.211 Lee, 2010, Cucurbitacin: ancient compound shedding new light on cancer treatment, Sci. World J., 10, 413, 10.1100/tsw.2010.44 Lee, 2011, Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma, Cancer Lett., 306, 161, 10.1016/j.canlet.2011.03.001 Duangmano, 2012, Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation, BMC Complement. Altern. Med., 12, 185, 10.1186/1472-6882-12-185 Lu, 2012, Cucurbitacin B regulates immature myeloid cell differentiation and enhances antitumor immunity in patients with lung cancer, Cancer Biother. Radiopharm., 27, 495, 10.1089/cbr.2012.1219 Aribi, 2013, The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer, Int. J. Cancer, 132, 2730, 10.1002/ijc.27950 Promkan, 2013, The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells, PLoS One, 8, e55732, 10.1371/journal.pone.0055732 Ahmed, 2014, Cucurbitacins: potential candidates targeting mitogen-activated protein kinase pathway for treatment of melanoma, J. Enzyme Inhib. Med. Chem., 29, 162, 10.3109/14756366.2012.762646 Gao, 2014, Inactivation of ATP citrate lyase by Cucurbitacin B: a bioactive compound from cucumber inhibits prostate cancer growth, Cancer Lett., 349, 15, 10.1016/j.canlet.2014.03.015 Zhang, 2014, Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells, Mol. Med. Rep., 10, 2905, 10.3892/mmr.2014.2581 El-Senduny, 2015, Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B, Tumour. Biol., 37, 685, 10.1007/s13277-015-3773-8 Hua, 2017, Protective effects of Cucurbitacin B on acute lung injury induced by sepsis in rats, Med. Sci. Monit., 23, 1355, 10.12659/MSM.900523 Guo, 2014, Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner, PLoS One, 9, e88140, 10.1371/journal.pone.0088140 Shang, 2014, Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN, Eur. Rev. Med. Pharmacol. Sci., 18, 3297 Zheng, 2014, Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SHSY5Y human neuroblastoma cells, Mol. Med. Rep., 10, 89, 10.3892/mmr.2014.2175 Niu, 2016, PTEN activation by DNA damage induces protective autophagy in response to Cucurbitacin B in hepatocellular carcinoma cells, Oxidat. Med. Cell. Long., 2016, 4313204 Shukla, 2016, Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis, Sci. Rep., 6, 21860, 10.1038/srep21860 Xie, 2016, Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway, Exp. Therap. Med., 12, 2709, 10.3892/etm.2016.3670 Zhang, 2017, Cucurbitacin B inhibits cell proliferation and induces apoptosis in human osteosarcoma cells via modulation of the JAK2/STAT3 and MAPK pathways, Exp. Therap. Med., 14, 805, 10.3892/etm.2017.4547 Sun, 2015, Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug resistance in human hepatoma cells, Eur. J. Pharmacol., 768, 28, 10.1016/j.ejphar.2015.10.003 Qu, 2017, Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells, Oncol. Lett., 14, 145, 10.3892/ol.2017.6148 Li, 1991, Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro, Nucleic Acids Res., 19, 6309, 10.1093/nar/19.22.6309 Zhao, 1999, Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G Protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors, J. Exp. Med., 190, 101, 10.1084/jem.190.1.101 Wang, 2002, Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity, FEBS Lett., 531, 295, 10.1016/S0014-5793(02)03539-1 Fang, 2011, Recent progress in medicinal investigations on trichosanthin and other ribosome inactivating proteins from the plant genus Trichosanthes, Curr. Med. Chem., 18, 4410, 10.2174/092986711797200499 Li, 2016, The anti-cancerous activity of recombinant trichosanthin on prostate cancer cell PC3, Biol. Res., 49, 21, 10.1186/s40659-016-0081-8 Li, 2017, Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface, Oncotarget, 8, 26460, 10.18632/oncotarget.15518 Fang, 2012, Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis, PLoS One, 7, e41592, 10.1371/journal.pone.0041592 Kang, 2013, Effect of trichosanthin on apoptosis and telomerase activity of nasopharyngeal carcinomas in nude mice, Journal of B.U.ON., 18, 675 Vázquez, 2012 Krishnan, 2014, Anti-inflammatory potential of beta-amyrin, a triterpenoid isolated from Costus igneus, Inflammopharmacology, 22, 373, 10.1007/s10787-014-0218-8 Kweifio-Okai, 1992, Antilipoxygenase activity of amyrin triterpenes, Res. Commun. Chem. Pathol. Pharmacol., 78, 367 Barton, 1955, The constitution and stereochemistry of euphol, J. Chem. Soc. (Resumed), 876, 10.1039/jr9550000876 Singh, 1989, Hypotensive activity of 8,24-Euphadien-3β-ol (Euphol), Planta Medica, 55, 498, 10.1055/s-2006-962079 Dutra, 2011, Preventive and therapeutic euphol treatment attenuates experimental colitis in mice, PLoS One, 6, e27122, 10.1371/journal.pone.0027122 Akihisa, 1997, Triterpene alcohols from camellia and sasanqua oils and their anti-inflammatory effects, Chem. Pharm. Bull. (Tokyo), 45, 2016, 10.1248/cpb.45.2016 Akihisa, 2002, Eupha-7, 9(11), 24-trien-3beta-ol (antiquol C) and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation, J. Nat. Prod., 65, 158, 10.1021/np010377y Dutra, 2011, Euphol, a novel cannabinoid agonist, prevents inflammatory and neuropathic persistent pain in rodents, Planta Medica, 77, SL46, 10.1055/s-0031-1282169 Dutra, 2012, Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system, Neuropharmacology, 63, 593, 10.1016/j.neuropharm.2012.05.008 Dutra, 2015, The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε, Neuroscience, 303, 126, 10.1016/j.neuroscience.2015.06.051 Wang, 2013, Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression, Mol. Med. Rep., 8, 1279, 10.3892/mmr.2013.1650 -w. Lin, 2014, Euphol from Euphorbia tirucalli induces human gastric cancer death through the degradation of TGFβR in lipid raft membrane microdomain (657.12), FASEB J., 28, s1 Pizzorno, 2013 Yao, 2013, Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation, Int. Immunopharmacol., 15, 316, 10.1016/j.intimp.2012.12.032 Head, 2005 Sharma, 2015, Occurrence of taraxerol and taraxasterol in medicinal plants, Pharmacogn. Rev., 9, 19, 10.4103/0973-7847.156317 Tan, 2011, Effects of taraxerol and taraxerol acetate on cell cycle and apoptosis of human gastric epithelial cell line AGS, Zhong Xi Yi Jie He Xue Bao, 9, 638, 10.3736/jcim20110610 Hong, 2016, Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration, Mol. Med. Rep., 13, 4541, 10.3892/mmr.2016.5105 Yao, 2017, Taraxerol Induces Cell apoptosis through a mitochondria-mediated pathway in HeLa cells, Cell J. (Yakhteh), 19, 512 Siddique, 2011, Beneficial health effects of lupeol triterpene: a review of preclinical studies, Life Sci., 88, 285, 10.1016/j.lfs.2010.11.020 Geetha, 2001, Anti-inflammatory activity of lupeol and lupeol linoleate in rats, J. Ethnopharmacol., 76, 77, 10.1016/S0378-8741(01)00175-1 Saleem, 2009, Novel anti-inflammatory and anti-cancer dietary triterpene, Cancer Lett., 285, 109, 10.1016/j.canlet.2009.04.033 Yasukawa, 1994, Inhibitory effect of karounidiol on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion, Biol. Pharm. Bull., 17, 460, 10.1248/bpb.17.460 Akihisa, 2001, Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines, Cancer Lett., 173, 9, 10.1016/S0304-3835(01)00689-9 Tolstikov, 2005, Betulin and its derivatives. Chemistry and biological activity, Chem. Sust. Dev., 13, 1 Dehelean, 2012, Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation, Chem. Cent. J., 6, 137, 10.1186/1752-153X-6-137 Ci, 2017, Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism, Cell Death Dis., 8, e2798, 10.1038/cddis.2017.39 Mullauer, 2009, Betulin is a potent anti-tumor agent that is enhanced by cholesterol, PLoS One, 4, e1, 10.1371/journal.pone.0005361 Król, 2015, Comprehensive review on betulin as a potent anticancer agent, BioMed Res. Int., 2015, 1, 10.1155/2015/584189 Ra, 2017, Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat, Korean J. Physiol. Pharmacol., 21, 19, 10.4196/kjpp.2017.21.1.19 Reina, 2011, Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca, Bioorg. Med. Chem. Lett., 21, 5888, 10.1016/j.bmcl.2011.07.092