Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo - controlled study

DARU Journal of Pharmaceutical Sciences - Tập 22 - Trang 1-7 - 2014
Elham Akhtari1, Firoozeh Raisi2, Mansoor Keshavarz1, Hamed Hosseini3,4, Farnaz Sohrabvand5, Soodabeh Bioos1, Mohammad Kamalinejad6, Ali Ghobadi7
1Department of Traditional Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Psychiatry, Fellow of the European Committee of Sexual Medicine (FECSM), Roozbeh Psychiatric Hospital, Psychiatric and Clinical Psychology, Research Center, Tehran University of Medical Sciences, Tehran, Iran
3School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4Clinical Trial Center, Tehran University of Medical Sciences, Tehran, Iran
5Department of Gynecology and Infertility, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
6Department of Pharmacognosy, School of Pharmacy Shaheed Beheshti University of Medical Sciences, Tehran, Iran
7Department of Traditional Medicine, School of Traditional Pharmacology, Tehran University of Medical Sciences, Tehran, Iran

Tóm tắt

Tribulus terrestris as a herbal remedy has shown beneficial aphrodisiac effects in a number of animal and human experiments. This study was designed as a randomized double-blind placebo-controlled trial to assess the safety and efficacy of Tribulus terrestris in women with hypoactive sexual desire disorder during their fertile years. Sixty seven women with hypoactive sexual desire disorder were randomly assigned to Tribulus terrestris extract (7.5 mg/day) or placebo for 4 weeks. Desire, arousal, lubrication, orgasm, satisfaction, and pain were measured at baseline and after 4 weeks after the end of the treatment by using the Female Sexual Function Index (FSFI). Two groups were compared by repeated measurement ANOVA test. Thirty women in placebo group and thirty women in drug group completed the study. At the end of the fourth week, patients in the Tribulus terrestris group had experienced significant improvement in their total FSFI (p < 0.001), desire (p < 0.001), arousal (p = 0.037), lubrication (p < 0.001), satisfaction (p < 0.001) and pain (p = 0.041) domains of FSFI. Frequency of side effects was similar between the two groups. Tribulus terrestris may safely and effectively improve desire in women with hypoactive sexual desire disorder. Further investigation of Tribulus terrestris in women is warranted.

Tài liệu tham khảo

Shifren JL, Monz BU, Russo PA, Segreti A, Johannes CB: Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 2008, 112 (5): 970-978. 10.1097/AOG.0b013e3181898cdb. Leiblum SR, KKoochaki PE, Rodenberg CA, Barton IP, Rosen RC: Hypoactive Sexual desire disorder in postmenopausal women: US results from the Women’s International Study of Health and Sexuality (WISHeS). Menopause. 2006, 13 (1): 46-56. 10.1097/01.gme.0000172596.76272.06. Dennerstein L, Koochaki P, Barton I, Graziottin A: Hypoactive sexual desire disorder in menopausal women: a survey of western European women. J Sex Med. 2006, 3 (2): 212-22. 10.1111/j.1743-6109.2006.00215.x. Hayes RD, Dennerstein L, Bennett CM, Fairley CK: What is the “true” prevalence of female sexual dysfunctions and does the way we assess these conditions have an impact?. J Sex Med. 2008, 5 (4): 777-778. 10.1111/j.1743-6109.2007.00768.x. Safarinejad MR: Female sexual dysfunction in population based study in Iran: prevalence and associated risk factors. Int J Impot Res. 2006, 18 (4): 382-395. 10.1038/sj.ijir.3901440. Davis SR, van der Mooren MJ, van Lunsen RH, Lopes P, Ribot J, Rees , Moufarege A, Rodenberg C, Buch A, Purdie DW: Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause. 2006, 13 (3): 387-396. 10.1097/01.gme.0000179049.08371.c7. Berman JR, Berman LA, Werbin TJ, Goldstein I: Female sexual dysfunction: anatomy, physiology, evaluation and treatment options. Curr Opin Urol. 1999, 9 (6): 563-568. 10.1097/00042307-199911000-00012. Segraves RT, Clayton A, Croft H, Wolf A, Wamock J: Bupropion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women. J Clin Psychopharmacol. 2004, 24 (3): 339-342. 10.1097/01.jcp.0000125686.20338.c1. Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, Jamshidi A, Ashrafi M, Mansouri P, Ghaeli P, Akhondzadeh S: Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum Psychopharmacol. 2013, 28 (1): 54-60. 10.1002/hup.2282. Simon JA: Opportunities for intervention in HSDD. J Fam Pract. 2009, 58 (7 Suppl Hypoactive): S26-30. Basson R, Leiblum S, Brotto L, Derogatis L, Fourcroy J, Fugl-Meyer K, Graziottin A, Heiman JR, Laan E, Meston C, Schover L, van Lankveld J, Schultz WW: Definitions of women’s sexual dysfunction reconsidered: advocating expansion and revision. J Psychosom Obstet Gynaecol. 2003, 24 (4): 221-229. 10.3109/01674820309074686. Clayton AH: The pathophysiology of hypoactive sexual desire disorder in women. International J of Gynecol Obstet. 2010, 110 (1): 7-11. 10.1016/j.ijgo.2010.02.014. Ibn-e-sina (Avicenna Husain): (Research of Ebrahim Shamsedine). Al-Qanun fit-tib [The Canon of Medicine]. 2005, Beirut, Lebanon: Alaalami Beirut library Press Aghili Khorasani MH: Makhzan al Advieh. 2001, Tehran, Iran: Bavardaran Press. Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences Mazaro-Costa R, Andersen ML, Hachul H, Tufik S: Medicinal plants as alternative treatments for female sexual dysfunction: Utopian vision or possible treatment in climacteric women?. J Sex Med. 2010, 7 (11): 3695-3714. 10.1111/j.1743-6109.2010.01987.x. Esfandiari A, Dehghan A, Sharifi S, Vesali E: Effect of Tribulus Terresteris extract on ovarian activity in immature wistar rat: a histological evaluation. J Anim Vet Adv. 2011, 7 (10): 883-886. Brotto LA: The DSM4 diagnostic criteria for hypoactiove sexual desire disorder in women. Arch Sex Behav. 2010, 39 (2): 221-239. 10.1007/s10508-009-9543-1. Zargari A: Medicinal plants, Vol 1; Tehran. 1989, Iran: Tehran University of Medical Sciences Press Abirami P, Rajendran A: GC-MS analysis of Tribulus terrestris. 1. Asian J Plant Sci Res. 2011, 1 (4): 13-16. Wiegel M, Meston C, Rosen R: The female sexual function index (FSFI): cross validation and development of clinical cutoff scores. J Sex Marital Ther. 2005, 31 (1): 1-20. 10.1080/00926230590475206. Rosen R, Brown C, Heiman J, Meston C, Shabsigh R, Ferguson D, Agostino R: The female sexualfunction index (FSFI): a multidimensional self-report instrument of female sexual function. J Sex Marital Thera. 2000, 26 (2): 191-208. 10.1080/009262300278597.