Trends in outcomes for very preterm infants in the southern region of Sweden over a 10‐year period

Wiley - Tập 98 Số 4 - Trang 648-653 - 2009
Pia Lundqvist1, Karin Källén2, Inger Hallström3, Lena Hellström‐Westas4
1Neonatal Unit, Children's Hospital, Lund University Hospital and Division of Nursing, Department of Health Sciences, Lund University, Sweden.
2Center of Reproductive Epidemiology, Tornblad Institute, Lund University, Sweden
3Division of Nursing, Department of Health Sciences and the Vardal Institute, Lund University, Sweden
4Division of Pediatrics, Lund University, Sweden and Department of Women's and Children's Health, Uppsala University, Sweden

Tóm tắt

AbstractAim: To investigate trends in mortality and morbidity in very preterm infants.Methods: Population‐based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995–2004). Time trends for mortality and common morbidities were explored using logistic regression analyses.Results: Data from 1614 liveborn infants were included. There was an increase in live born infants below 25 gestational weeks, annual odds ratio (OR) 1.15 (95% CI: 1.08–1.23) and a decrease in mortality annual OR 0.82 (95% CI: 0.69–0.98). The rates of bronchopulmonary dysplasia (BPD) and sepsis increased during the study period, annual ORs of 1.10 (95% CI: 1.04–1.17) and 1.09 (95% CI: 1.03–1.16). The duration of mechanical ventilation increased for surviving infants <25 gestational weeks (p = 0.003), while the duration of continuous positive airway pressure (CPAP) increased for infants <28 gestational weeks (p = <0.001). There were no changes in the rates of intraventricular haemorrhages (IVH, 3–4), retinopathy of prematurity (ROP, 3–5), seizures or necrotizing enterocolitis (NEC).Conclusion: During the 10‐year period changes in mortality and morbidity were most pronounced for infants with GA <28 gestational weeks. The increasing rate of sepsis was present in infants <28 gestational weeks, whereas the increase in BPD was demonstrated in the whole study population <32 gestational weeks.

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Wiley

Tập 98 Số 4

648-653

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