Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus

Applied Physiology, Nutrition and Metabolism - Tập 35 Số 6 - Trang 797-804 - 2010
Cuifeng Zhu1,2,3,4, Guan-Zhi Li1,2,3,4, Hong-Bin Peng1,2,3,4, Fan Zhang1,2,3,4, Yun Chen1,2,3,4, Yong Li1,2,3,4
1Department of Endocrinology, Shenzhen Hospital of Peking University, Shenzhen 518036, China.
2Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 10083, China
3Department of Nutrition, Shenzhen Hospital of Peking University, Shenzhen 518036, China.
4Department of Ultrasound Division, Shenzhen Hospital of Peking University, Shenzhen 518036, China.

Tóm tắt

This study was aimed at examining the therapeutic effects of marine collagen peptides (MCPs) from fish hydrolysate in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 100 diabetic patients and 50 healthy controls were recruited. Diabetic patients were randomized into treatment and control groups. The patients in the treatment group received an additional 13 g of MCPs daily for 3 months. Their blood samples were collected before, and 1.5 and 3 months after, treatment to evaluate glucose and lipid metabolism. The levels of serum high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), bradykinin, prostacyclin (PGI2), and adipokines were determined. Significantly reduced levels of fasting blood glucose, human glycated hemoglobin A1c (GHbA1c), fasting blood insulin, total triglycerides, total cholesterol, low-density lipoprotein, and free-fatty acids, but increased levels of insulin sensitivity index and HDL were observed in T2DM patients following treatment with MCPs for 1.5 and 3 months. The values of these measures were significantly lower or higher than those of patient controls (p < 0.01), respectively. Interestingly, significantly decreased levels of hs-CRP and NO, but increased levels of bradykinin, PGI2, and adiponectin were detected in MCP-treated T2DM patients (p < 0.01), as compared with their basal values or the levels in patient controls. MCP treatment improved glucose and lipid metabolism in diabetic patients.

Từ khóa


Tài liệu tham khảo

10.1586/14779072.7.2.147

10.1016/j.jchromb.2003.11.005

10.3132/dvdr.2006.009

Bhatheja R., 2006, J. Cardiovasc. Nurs., 21, 298, 10.1097/00005082-200607000-00011

10.1001/jama.290.4.486

10.1002/iub.142

Díez Espino J., 2010, Aten Primaria,, 42, 2, 10.1016/S0212-6567(10)70002-0

10.2337/diacare.28.10.2497

10.1111/j.1464-5491.2005.01658.x

Freese R., 1997, Am. J. Clin. Nutr., 66, 591, 10.1093/ajcn/66.3.591

Gelman L., 2007, Biochim. Biophys. Acta, 1771, 1094, 10.1016/j.bbalip.2007.03.004

10.1016/j.jvn.2010.10.002

10.1038/nrm2391

10.1097/00041433-200202000-00008

10.1002/jcp.10294

Henriksen E.J., 1998, Am. J. Physiol., 275, R40

Hotta K., 2000, Arterioscler. Thromb. Vasc. Biol., 20, 1595, 10.1161/01.ATV.20.6.1595

10.1056/NEJM197608192950804

10.1136/gut.2008.162859

10.1097/ALN.0b013e3181799d45

10.1586/14779072.6.3.323

10.1046/j.1440-1681.2000.03243.x

10.1139/H07-083

10.1002/jps.21198

10.1073/pnas.091021198

Pei X.R., 2008, Zhonghua Yu Fang Yi Xue Za Zhi, 42, 235

10.2307/2529712

Qi W.H., 2007, Zhonghua. Xin Xue Guan Bing Za Zhi, 35, 457

10.1210/jc.2008-1613

10.1111/j.1559-4564.2007.06368.x

10.1038/35053000

10.1007/BF00398058

Wang J.B., 2008, Zhonghua Yu Fang Yi Xue Za Zhi, 42, 226

10.1111/j.1464-5491.2007.02186.x

Zhang Z.F., 2008, Zhonghua Yu Fang Yi Xue Za Zhi, 42, 221

Thông tin
Thông tin xuất bản

Applied Physiology, Nutrition and Metabolism

Tập 35 Số 6

797-804

Thông tin tác giả