Treatment wish of individuals with known and unknown restless legs syndrome in the community

Deutsche Zeitschrift für Nervenheilkunde - Tập 255 - Trang 1365-1371 - 2008
S. Happe1, M. Vennemann2, S. Evers3, K. Berger2
1Dept. of Clinical Neurophysiology, Klinikum Bremen-Ost/University of Göttingen, Bremen, Germany
2Dept. of Epidemiology and Social Medicine, University of Münster, Münster, Germany
3Dept. of Neurology, University of Münster, Münster, Germany

Tóm tắt

Restless legs syndrome (RLS) is a frequent sleep disorder with a prevalence of 5 % to 15 % in Caucasion populations. Dopaminergic treatment is known to reduce sensorimotor RLS symptoms and is approved for RLS, but not all patients ask for treatment. About 2 % to 3 % of patients presenting to a primary care physician require RLS-specific treatment. The overall treatment preference of RLS sufferers, however, is still unknown. The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany. Cross-sectional health survey with face-to-face interviews with 1312 participants in the Dortmund Health Study. RLS was assessed with standardized, validated questions addressing the four minimal diagnostic criteria for RLS defined by the International Restless Legs Syndrome Study Group. Participants were aged 25 to 75 years and were randomly selected from the city register. The overall prevalence of individuals with a known doctor diagnosis of RLS was 2.3 %. In addition, 6.5 % fulfilled the four minimal criteria but did not know about this diagnosis yielding an overall prevalence of 8.8 %. Prevalence was higher in women (10.2 %) and German descendents (9.2 %) compared to men (7.1 %) and migrants (6.7 %). Almost 60 % of all RLS cases reported symptoms at least once a week. 33.3 % of cases with a known RLS diagnosis and 14.1 % with an unknown diagnosis had an RLS treatment wish. The latter is determined by knowledge of the diagnosis, daily symptoms, diabetes and sleep disturbance. About every fourth RLS case knows about the diagnosis and overall every fifth RLS case wishes medication to effectively reduce symptoms, corresponding to 1.6 % of the whole study population.

Tài liệu tham khảo

Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisir J (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institute of Health. Sleep Med 4:101–119 Berger K, Lüdemann J, Trenkwalder C, John U, Kessler C (2004) Sex and the risk of restless legs syndrome in the general population. Arch Intern Med 164:196–202 Berger K, von Eckardstein A, Trenkwalder C, Rothdach A, Junker R, Weiland SK (2002) Iron metabolism and the risk of restless legs syndrome in an elderly general population: the MEMO study. J Neurol 249:1195–1199 Buysse DJ, Reynolds CF 3rd, Monks TH, et al. (1989) The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Res 28:193–213 Garcia-Borreguero D, Egatz R, Winkelmann J, Berger K (2006) Epidemiology of restless legs syndrome: the current status. Sleep Med Rev 10:153–167 Hening W, Walters AS, Allen RP, Montplaisir J, Myers A, Ferini-Strambi L (2004) Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med 5:237–246 Högl B, Kiechl S, Willeit J, et al. (2005) Restless legs syndrome. A communitybased study of prevalence, severity, and risk factors. Neurology 64:1920–1924 Paulus W, Trenkwalder C (2006) Less is more: Pathophysiology of dopaminergic- therapy-related augmentation in restless legs syndrome. Lancet Neurol 5:878–886 Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K (2000) Prevalence and risk factors of RLS in an elderly population. The MEMO study. Neurology 54:1064–1068 Sevim S, Dogu O, Camdeviren H, et al. (2003) Unexpectedly low prevalence and unusual characteristics of RLS in Mersin, Turkey. Neurology 61:1562–1569 Walters AS (1995) Toward a better definition of restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord 10:634–642 Willis T (1685) The London Practice of Physick. London, England: Bassett & Crooke, 404 Youakun R (1996) Nightwalkers: Do your legs seem to have a life of their own – your torment has a name. Modern maturity 35:82–83