Treating metastatic castration-resistant prostate cancer with novel polyamine-free oral nutritional supplementation: Phase I study

Cohen, 1998 Mohan, 1999, Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans, Clin Cancer Res, 5, 143 Cipolla, 1993, Polyamines and prostatic carcinoma: clinical and therapeutic implications, Eur Urol, 24, 124, 10.1159/000474279 Cipolla, 1996, Pretherapeutic erythrocyte polyamine spermine levels discriminate high risk relapsing patients with M1 prostate carcinoma, Cancer, 78, 1055, 10.1002/(SICI)1097-0142(19960901)78:5<1055::AID-CNCR16>3.0.CO;2-1 Seiler, 1990, Endogenous and exogenous polyamines in support of tumor growth, Cancer Res, 50, 5077 Chamaillard, 1997, Polyamine deprivation prevents the development of tumour-induced immune-suppression, Br J Cancer, 76, 365, 10.1038/bjc.1997.391 Cipolla, 2003, Polyamine-reduced diet in metastatic hormone-refractory prostate cancer patients, Biochem Soc Trans, 31, 384, 10.1042/bst0310384 Cipolla, 2007, Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long term observance and tolerance in prostate carcinoma patients, Amino Acids, 33, 203, 10.1007/s00726-007-0524-1 Petrylak, 2002, Chemotherapy for androgen-independent prostate cancer, Semin Urol Oncol, 20, 31, 10.1053/suro.2002.35052 Tannock, 1999, Chemotherapy with mitoxantrone plus prednisolone or prednisolone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points, J Clin Oncol, 14, 1756, 10.1200/JCO.1996.14.6.1756 Tannock, 1999, Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer, N Engl J Med, 351, 1502, 10.1056/NEJMoa040720 Loftis, 2003, The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications, Pharmacol Ther, 97, 55, 10.1016/S0163-7258(02)00302-9 Ransom, 1988, Cooperative modulation of (3H) MK801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine and polyamines, J Neurochem, 51, 830, 10.1111/j.1471-4159.1988.tb01818.x Ransom, 1991, Polyamine and ifenprodil interactions with the NMDA receptor's glycine site, Eur J Pharmacol, 208, 67, 10.1016/0922-4106(91)90052-J Rock, 1991, Spermine and related polyamines produce a voltage-dependant reduction of the N-methyl-D-aspartate receptor single-channel conductance, Mol Pharmacol, 41, 83 Kergozien, 1996, Polyamine deprivation provokes an antalgic effect, Life Sci, 58, 2209, 10.1016/0024-3205(96)00215-9 Kergozien, 1999, Polyamine deprivation alters formalin-induced nociceptive behavior and spinal C-fos expression and prevents morphine effect, Life Sci, 65, 2175, 10.1016/S0024-3205(99)00482-8 Tan-No, 2000, Intrathecally administered spermine produces the scratching, biting and itching behaviour in mice, Pain, 86, 55, 10.1016/S0304-3959(99)00312-7 Rivat, 2008, Polyamine deficient diet to relieve pain hypersensitivity, Pain, 137, 125, 10.1016/j.pain.2007.08.021 Cipolla, 1996, In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide, Urol Res, 24, 93, 10.1007/BF00431085