Transport of molecules across tumor vasculature

Cancer and Metastasis Reviews - Tập 6 - Trang 559-593 - 1987
Rakesh K. Jain1
1Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, USA

Tóm tắt

The vascular-extravascular exchange of fluid and solute molecules in a tissue is determined by three transport parameters (vascular permeability, P, hydraulic conductivity, Lp, and reflection coefficient, σ); the surface area for exchange, A; and the transluminal concentration and pressure gradients. The transport parameters and the exchange area for a given molecule are governed by the structure of the vessel wall. In general, tumor vessels have wide interendothelial junctions; large number of fenestrae and transendothelial channels formed by vesicles; and discontinuous or absent basement membrane. While these factors favor movement of molecules across tumor vessels, high interstitial pressure and low microvascular pressure may retard extravasation of molecules and cells, especially in large tumors. These characteristics of the transvascular transport have significant implications in tumor growth, metastasis, detection and treatment.

Tài liệu tham khảo

Jain RK, Weissbrod J, Wei J: Mass transfer in tumors: Characterization and applications in chemotherapy. Advances in Cancer Research 21: 37–47, 1980

Gerlowski LE, Jain RK: Physiologically based pharmacokinetics: Principles and applications. J Pharm Sci, 72 (10): 1103–1127, 1983

Jain RK: Mass and heat transfer in tumors. Advances in Transport Process 3: 205–339, 1984

Jain RK: Transport of macromolecules in tumor microcirculation. Biotech Prog 1: 81–84, 1985

Poste G: Drug targeting in cancer therapy. In: Gregoriadis G, Poste G, Senior J, Trouet A (eds) Receptor-mediated Targeting of Drugs. Plenum Publishing Corporation, New York, 1985, pp 427–474

Schlom J: Basic principles and applications of monoclonal antibodies in the management of carcinomas. Cancer Res 46: 3225–3238, 1986

Winkler C (editor): Nuclear Medicine in Clinical Oncology. New York: Springer-Verlag, 1986

Jain RK: Transport of molecules in the tumor interstitium: A review. Cancer Res, 47: 3038–3050, 1987

Jain RK, Ward-Hartley K: Tumor blood flow: Characterization, modifications, and role in hyperthermia. I.E.E.E. Trans Sonics and Ultrasonics, SU-31 (5): 504–526, 1984

Poste G, Kirsh R, Bugelski P: Liposomes as a drug delivery system in cancer therapy. In: Sunkara P (ed) Novel Approaches to Cancer Chemotherapy. Academic Press, New York, 1984, pp 165–230

Weiss L. Principles of Metastasis, New York, Academic Press, 1985

Kawaguchi T, Nakamura K: Analysis of the lodgement and extravasation of tumor cells in experimental models of hematogenous metastasis. Cancer and Metastasis Reviews 5: 77–94, 1986

Jain R, Ward-Hartley K: Dynamics of cancer cell interactions with microvasculature and interstitium. Biorheology 24: 117–125, 1987

Starling EH: On the absorption of fluids from the connective tissue spaces. J Physiol (London) 19: 312–326, 1896

Gullino PM: Extracellular compartments of solid tumors. In: Becker FF (ed) Cancer, Volume 3, Plenum Press, New York, 1975, pp 327–354

Wiedeman MP, Tuma RF, Mayrovitz HN: An Introduction to Microcirculation, New York, Academic Press, 1981

Wiedeman MP: Architecture. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 2. American Physiological Society, Bethesda, MD, 1984, pp 11–40

Simionescu M, Simionescu N: Ultrastructure of the microvascular wall: functional correlations. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 3. American Physiological Society, Bethesda, MD, 1984, pp 41–101

Persson CGA, Svensjö E: Vascular responses and their suppression: drugs interfering with venular permeability. Handbook of Inflammation, 5: 61–82, 1985

Folkman J: Tumor angiogenesis. Adv Cancer Res 43: 175–203, 1985

Warren BA: The vascular morphology of tumors. In: Peterson HI (ed) Tumor Blood Circulation, Chapter 1. CRC Press Inc., Boca Raton FL, 1979, pp 1–47

Warren BA:In vivo and electron microscopic study of vessels in a hemangiopericytoma of the hamster. Angiologica, 5: 230, 1968

Warren BA: The ultrastructure of the microcirculation of the advancing edge of Walker 256 carcinoma. Microvasc Res 2: 443–453, 1970

Groscurth P, Kistler G: Human renal cell carcinoma in the nude mouse: long term observations. Beitr Pathol 160: 337, 1977

Hirano A, Matsui T: Vascular structures in brain tumors. Human Pathol 6: 611–621, 1975

Vogel AW: Intratumoral vascular changes with increased size of a mammary adenocarcinoma: New methods and results. J Natl Cancer Inst 34: 571–578, 1965

Warren BA, Chauvin WJ: Transmission and scanning electron microscopy of renal adenocarcinoma. Ann Royal Con Phys Surg Can 10: 74, 1977

Dvorak HF, Singer DR, Dvorak AM, Harvery VS, McDonagh J: Regulation of extravascular coagulation by microvascular permeability. Science 227: 1059–1061, 1985

Warren BA, Shubik P: The growth of the blood supply to melanoma transplants in the hamster cheek pouch chamber. Lab Invest 15: 464, 1966

Cliff WJ: Observations on healing tissue: a combined light and electron microscopic investigation. Philos Trans Roy Soc, London, Series B, 246: 305–325, 1963

Warren BA, Shubik P, Feldman R: Metastasis via the blood stream: the method of intravasation of tumor cells in a transplantable melanoma of the hamster. Cancer Lett 4: 245–251, 1978

Krogh A: The Anatomy and Physiology of Capillaries. New Haven, CT: Yale Univ Press, 1929, p 326

Landis EM: Micro-injection studies of capillary permeability. II. The relation between capillary pressure and the rate at which fluid passes through the walls of single capillaries. Am J Physiol 82: 217–238, 1927

Pappenheimer JR, Renkin EM, Borrero LM: Filtration, diffusion and molecular sieving through peripheral capillary membranes: A contribution to the pore theory of capillary permeability. Am J Physiol 167: 13–46, 1951

Palade GE: Fine structure of blood capillaries. [Abstract], J Appl Physiol 24: 1424, 1953

Karnovsky MJ: The ultrastructural basis of capillary permeability studies with peroxidase as a tracer. J Cell Biol 35: 213–236, 1967

Simionescu N, Simionescu M, Palade GE: Permeability of muscle capillaries to small heme-peptides: Evidence for the existence of patent transendothelial channels. J Cell Biol 64: 586–607, 1975

Bruns RR, Palade GE: Studies on blood capillaries. I. General organization of blood capillaries in muscle. J Cell Biol 37: 244–276, 1968

Bruns RR, Palade GE: Studies on blood capillaries. II. Transport of ferritin molecules across the wall of muscle capillaries. J Cell Biol 37: 277–299, 1968

Bundgaard M, Frokjaer-Jensen J, Crone C: Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface. Proc Natl Acad Sci USA 76: 6439–6442, 1979

Crone C: The function of capillaries. Recent Adv in Physiology 10: 125–162, 1984

Renkin EM, Michel CC (eds): Handbook of Physiology, Section 2 — The Cardiovascular System, Volume IV — Microcirculation. Am Physiological Soc, Bethesda, MD, 1984

Renkin EM: Multiple pathways of capillary permeability. Circ Res 41: 735–743, 1977

Duling BR, Berne RM: Longitudinal gradients in periarteriolar oxygen tension. Circ Res 27: 669–678, 1970

Scow RO, Blanchette-Mackie EJ, Smith LC: Role of capillary endothelium in the clearance of chylomicrons. Circ Res 39: 149–162, 1978

Taylor AE, Granger DN: Exchange of macromolecules across the microcirculation. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, MIcrocirculation, Chapter 11. American Physiology Society, Bethesda, MD, 1984, pp 467–520

Curry FE: Mechanics and thermodynamics of transcapillary exchange. In: Renkin EM, Michel CC (eds) Handbook of Physiology-The Cardiovascular System, Volume IV, Microcirculation, Chapter 8. American Physiological Soc, Bethesda, MD, 1984, pp 309–374

Underwood JCE, Carr I: The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcoma. J Pathol 107: 157–166, 1972

Papadimitriou JM, Woods AE: Structural and functional characteristics of the microcirculation in neoplasms. J Pathol 116: 65, 1975

Ward JD, Hadfield MG, Becker DP, Lovings ET: Endothelial fenestrations and other vascular alterations in primary melanoma of the central nervous system. Cancer 34: 1982–1991, 1976

Waggener JD, Beggs JL: Vasculature of neural neoplasma. Adv Neurol 15: 27, 1976

Kedem O, Katchalsky A: Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochim Biophys Acta 27: 229–245, 1958

Staverman AJ: The theory of measurement of osmotic pressure. Rec Trav Chim Pays-Bas, 70: 344–352, 1951

Kedem O, Katchalsky A: A physical interpretation of the phenomenological coefficients of membrane permeability. J Gen Physiol 45: 143–179, 1961

Patlak CS, Goldstein DA, Hoffman JF: The flow of solute and solvent across a two-membrane system. J Theor Biol 5: 426–442, 1963

Crone C, Levitt DG: Capillary permeability to small solutes. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 10. American Physiological Society, Bethesda, MD, 1984, pp 411–466

Michel CC: Fluid movements through capillary wall. In: Renkin EM, Michel CC (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 9. American Physiological Society, Bethesda, MD, 1984, pp 375–409

Landis EM, Gibbon Jr JH: The effects of temperature and of tissue pressure on the movement of fluid through the human capillary wall. J Clin Invests 12: 105–138, 1933

Gore RW, McDonagh PF: Fluid exchange across single capillaries. Annual Rev Physiol 42: 337–357, 1980

Curry FE, Huxley VH, Sarelius IH: Techniques in the microcirculation: Measurements of permeability, pressure and flow. In: Linden RJ (ed) Techniques in the Life Sciences-Cardiovascular Physiology, Vol. P3/1. Elsevier, New York, 1983, pp 1–34

Zweifach BW, Intaglietta M: Mechanics of fluid movement across single capillaries in the rabbit. Microvasc Res 1: 83–101, 1968

Smaje LH, Zweifach BW, Intaglietta M: Micropressures and capillary filtration coefficients in single vessels of the cremaster muscle of the rat. Microvasc Res 2: 96–110, 1970

Lee JS, Smaje LH, Zweifach BW: Fluid movement in occluded single capillaries of rabbit omentum. Circ Res 28: 358–370, 1971

Gore RW: Fluid exchange across single capillaries in rat intestinal muscle. Am J Physiol 242 (Heart Circ Physiol) 11: H268-H287, 1982

Clough G, Smaje LH: Changes in capillary permeability in scurvy. Biorheology 14: 203, 1977 [Abstract]

McDonagh PF, Gore RW: Comparison of hydraulic conductivities in single capillaries of red versus white skeletal muscle. [Abstract]. Microvasc Res 15: 269, 1978

Frazer PA, Smaje LH, Verrinder A: Microvascular pressure and filtration coefficients in the cat mesentery. J Physiol, London, 283: 439–456, 1978

Smaje LH, Frazer PA, Clough G: The distensibility of single capillaries and venules in the cat mesentery. Microvasc Res 20: 358–376, 1980

Michel CC, Mason JC, Curry FE, Tooke JE, Hunter PA: A development of the Landis technique for measuring the filtration coefficient of individual capillaries in the frog mesentery. Q.J. Exp Physiol 59: 283–309, 1974

Curry FE, Mason JC, Michel CC: Osmotic reflection coefficients of capillary walls to low molecular weight hydrophilic solutes measured in single perfused capillaries of the frog mesentery. J Physiol 261: 319–336, 1976

Levick JR, Michel CC: A densitometric method for determining the filtration coefficients of single capillaries in the frog mesentery. Microvasc Res 13: 141–151, 1977

Mason JC, Curry FE, Michel CC: The effects of protein upon the filtration coefficient of individually perfused frog mesenteric capillaries. Microvasc Res 13: 185–202, 1977

Michel CC: Filtration coefficients and osmotic reflection coefficients of the walls of single frog mesenteric capillaries. J Physiol, London, 309: 355, 1980

Curry FE: Permeability coefficients of the capillary wall to low molecular weight hydrophilic solutes measured in single perfused capillaries of frog mesentery. Microvasc Res 17: 290–308, 1979

Curry FE, Frokjaer-Jensen J: Water flow across the walls of single muscle capillaries in the frog, Rana Pipiens. J Physiol 350: 293–307, 1984

Mellander S, Oberg B, Odelram H: Vascular adjustments to increased transmural pressure in cat and man with special reference to shifts in capillary fluid transfer. Acta Physiol Scand 61: 34–48, 1964

Sejrsen P, Henriksen O, Paaske WP: Effect of orthostatic blood pressure changes upon capillary filtration-absorption rate in the human calf. Acta Physiol Scand 111: 287–291, 1981

Folkow B, Mellander S: Measurements of capillary filtration coefficient and its use in studies of the control of capillary exchange. In: Crone C, Lassen NA (eds) Capillary Permeability, Copenhagen: Munksgaard, 1970, p 614–623 (Alfred Benzon Symp. 2)

Richardson PDI, Granger DN, Taylor AE: Capillary filtration coefficient: the technique and its application to the small intestine. Cardiovasc Res 13: 547–561, 1979

Mortillaro NA, Taylor AE: Interaction of capillary and tissue forces in the cat small intestine. Circ Res 39: 349–358, 1976

Diana JN, Long SC, Yao H: Effect of histamine on equivalent pore radius in capillaries of isolated dog hind-limb. Microvasc Res 4: 413–437, 1972

Chen HI, Granger HJ, Taylor AE: Interaction of capillary, interstitial and lymphatic forces in the canine hind paw. Circ Res 39: 245–254, 1976

Johnson P, Hanson KM: Capillary filtration in the small intestine of the dog. Circ Res 19: 766–773, 1966

Guyton AC, Lindsey AW: Effects of elevated left atrial pressure and decreased plasma protein concentration on the development of pulmonary edema. Circ Res 7: 649–657, 1959

Gaar Jr KA, Taylor AE, Owens LJ, Guyton AC: Pulmonary capillary pressure and filtration coefficient in the isolated perfused lung. Am J Physiol 213: 910–914, 1967

Perl W, Chowdhury P, Chinard FP: Reflection coefficients of dog lung endothelium to small hydrophilic solutes. Am J Physiol 228: 797–809, 1975

Drake RE, Smith JH, Gabel JC: Estimation of the filtration coefficient in intact dog lungs. Am J Physiol 238: H430-H438, 1980

Renkin EM, Zaun BD: Effects of adrenal hormones on capillary permeability in perfused rat tissues. Am J Physiol 180: 498–502, 1955

Rippe B, Kamiya A, Folkow B: Simultaneous measurements of capillary diffusion and filtration exchange during shifts in filtration-absorption and at graded alterations in the capillary permeability surface area product (PS). Acta Physiol Scand 104: 318–336, 1978

Vargas F, Johnson JA: Permeability of rabbit heart capillaries to nonelectrolytes. Am J Physiol 213: 87–93, 1967

Nicolaysen G: Increase in capillary filtration rate resulting from reduction in the intravascular calcium ion concentration. Acta Physiol Scand 81: 517–527, 1971

Wangensteen OD, Lysaker E, Savaryn P: Pulmonary capillary filtration and reflection coefficients in the adult rabbit. Microvasc Res 19: 239–241, 1977

Fenstermacher JD, Johnson JA: Filtration and reflection coefficients of the rabbit blood-brain barrier. Am J Physiol 211: 341–346, 1966

Erdmann AJ III, Vaughan Jr TR, Brigham KL, Woolverton WC, Staub NC: Effect of increased vascular pressure on lung fluid balance in unanesthetized sheep. Circ Res 37: 271–284, 1975

Parker JC, Parker RE, Granger DN, Taylor AE: Vascular permeability and transvascular fluid and protein transport in the dog lung. Circ Res 48: 549–560, 1981

Vargas F, Johnson JA: An estimate of reflection coefficients for rabbit heart capillaries. J Gen Physiol 47: 667–677, 1964

Curry FE, Huxley VH, Adamson RH: Permeability of single capillaries to intermediate-sized colored solutes. Am J Physiol 245: H495-H505, 1983

Vargas FF, Blackshear GL: Transcapillary osmotic flows in thein vitro perfused heart. Am J Physiol, 240 (Heart Circ Physiol, 9): H448-H456, 1981

Renkin EM, Curry FE: Transport of water and solutes across capillary endothelium. In: Giebisch G, Tosteson DC (eds) Transport Across Biological Membranes: Transport Organs, Berlin: Springer-Verlag, Vol. 4, p 1–45, 1978

Ballard K, Perl W: Osmotic reflection coefficients of canine subcutaneous adipose tissue endothelium. Microvasc Res 16: 224–236, 1978

Granger DN, Granger JP, Brace RA, Parker RE, Taylor AE: Analysis of the permeability characteristics of cat intestinal capillaries. Circ Res 44: 335–344, 1979

Bassingthwaighte JB, Goresky CG: Modeling in the analysis of solute and water exchange in the microvasculature. In: Renkin EM, Michel CG (eds) Handbook of Physiology — The Cardiovascular System, Section 2, Volume IV, Microcirculation, Chapter 13. American Physiological Society, Bethesda, MD, 1984, pp 549–626

Miles AA, Miles EM: Vascular reactions to histamine, histamine-liberator, and leukotaxine in the skin of guinea pigs. J Physiol 118: 228–257, 1952

Song CW, Levitt SH: Quantitative study of vascularity in Walker carcinoma 256, Cancer Res 31: 587–589, 1971

Clement JJ, Song CW, Levitt SH: Changes in functional vascularity and cell number following X-irradiation of a murine carcinoma. Int J Radiation Oncology, Biol Phys 1: 671–678, 1976

Song CW, Kang MS, Rhee JG, Levitt SH: Effect of hyperthermia on vascular function in normal and neoplastic tissues. Ann NY Acad Sci 335: 35–43, 1980

Sands H, Shah SA, Gallagher BM: Vascular volume and permeability of human and murine tumors grown in athymic mice. Cancer Lett 27: 15–21, 1985

Zweifach BW, Lipowsky HH: Pressure-flow relations in blood and lymph microcirculation. In: Renkin EM, Michel CC (eds) Handbook of Physiology-The Cardiovascular System, Volume IV, Microcirculation, Chapter 7. American Physiological Soc, Bethesda, MD, 1984, pp 251–307

O'Connor SW, Bale WF: Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors. Cancer Res 44: 3719–3723, 1984

Fenstermacher JD, Blasberg RG, Patlak CS: Methods for quantifying the transport of drugs across brain barrier systems. Pharmacol Ther 14: 217–248, 1981

Gullino PM, Grantham FH: Studies on the exchange of fluids between host and tumor. I. A method for growing ‘tissue-isolated’ tumors in laboratory animals. J Natl Cancer Inst 27: 679–693, 1961

Gullino PM: Techniques for the study of tumor physiopathology. Methods in Cancer Research 5: 45–91, 1970

Jain RK, Wei J, Gullino PM: Pharmacokinetics of methotrexate in solid tumors. J Pharmacokin Biopharma 7: 181–194, 1979

Bjork J, Smedegard G, Svensjo E, Arfors KE: The use of the hamster cheek pouch for intravital microscopy studies of microvascular events. Prog Appl Microcirc 6: 41–53, 1984

Baxter LT, Jain RK, Svensjo E: Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: Effects of vasoactive drugs. Microvasc Res. (in press), 1987

Nugent LJ, Jain RK: Monitoring transport in the rabbit ear chamber. Microvasc Res 24: 204–209, 1982

Nugent LJ, Jain RK: Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed. Am J Physiol 246: H129-H137, 1984

Nugent LJ, Jain RK: Extravascular diffusion in normal and neoplastic tissues. Cancer Res 44: 238–244, 1984

Gerlowski LE, Jain RK: Microvascular permeability of normal and neoplastic tissues. Microvasc Res 31: 288–305, 1986

Crone C, Frokjer-Jensen J, Friedman JJ, Christensen O: The permeability of single capillaries to potassium ions. J Gen Physiol 71: 195–220, 1978

Curry FE, Joyner WL: The effect of histamine, 40/80 and A23187 on albumin permeability in frog venular capillaries. [Abstract]. Fed Proc 45: 1159, 1986

Hansen AJ, Lund-Andersen H, Crone C: K+-permeability of the blood-brain barrier, investigated by aid of a K+-sensitive microelectrode. Acta Physiol Scand 101: 438–445, 1977

Olesen SP, Crone C: Electrical resistance of muscle capillary endothelium. Biophys J 42: 31–41, 1983

Frokjaer-Jensen J: Permeability of single muscle capillaries to potassium ions. Microvasc Res 24: 168–183, 1982

Joyner WL, Curry FE: Measurement of albumin permeability coefficients in single capillaries of hamster mesentery. [Abstract]. Fed Proc 45: 583, 1986

Jain RK, Gerlowski LE: Extravascular transport in normal and tumor tissues. CRC Crit Rev Oncology/Hematology 5: 115–170, 1986

Bassingthwaighte JB, Yipintsoi T, Harvey RB: Microvasculature of the dog left ventricular myocardium. Microvasc Res 7: 229–249, 1974

Turek Z: Grandtner M, Kreuzer F: Cardiac hypertrophy, capillary and muscle fiber density, muscle fiber diameter, capillary radius and diffusion distance in the myocardium of growing rats, adapted to a simulated altitude of 3500 m. Pfluegers Arch 335: 19–28, 1972

Metzger H, Heuber-Metzger S, Steinacker A, Struber J: Staining PO2 measurement sites in the rat brain cortex and quantitative morphometry of the surrounding capillaries. Pfluegers Arch 338: 21–27, 1980

Bar T: The vascular system of the cerebral cortex. In: Brodal A, Hild W, van Limborgh J, Ortmann R, Schiebler TH, Tondury G, Wolff E (eds) Advances in Anatomy, Embryology and Cell Biology, Vol 59, Springer-Verlag, Berlin, 1980

Pawlik G, Rackl A, Bing RJ: Quantitative capillary topography and blood flow in the cerebral cortex of cats: anin vivo microscopic study. Brain Res 208: 35–58, 1981

Vimtrup B: On the number, shape, structure and surface area of the glomeruli in the kidneys of man and mammals. Am J Anat 41: 123–151, 1928

Putter A: Aktive Oberflache und Organfunktion. Z Allg Physiol 12: 125–214, 1911

Crone C: Does ‘restricted diffusion’ occur in muscle capillaries? Proc Soc Exp Biol Med 112: 453–455, 1963

Renkin EM, Gilmore JP: Glomerular filtration. In: Hamilton WF, Dow P (eds) Handbook of Physiology: Circulation, American Physiological Soc, Washington D.C., 1973

Perry MA: Capillary filtration and permeability coefficients calculated from measurements of interendothelial cell junctions in rabbit lung and skeletal muscle. Microvasc Res 19: 142–157, 1980

Weibel ER: Morphological basis of alveolar-capillary gas exchange. Physiol Rev 53: 419–495, 1973

Eriksson E, Myrhage R: Microvascular dimensions and blood flow in skeletal muscle. Acta Physiol Scand 86: 211–222, 1972

Schmid-Schönbein G, Zweifach B, Kovalcheck S: The application of stereological principles to morphometry of the microcirculation in different tissues. Microvasc Res 12: 303–317, 1977

Casley-Smith JR, Green HS, Harris JL, Wadey PJ: The quantitative morphology of skeletal muscle capillaries in relation to permeability. Microvasc Res 10: 43–64, 1975

Myrhage R, Hudlicka O: The microvascular bed and capillary surface area in the rat extensor halucis propius muscle (EHP). Microvasc Res 11: 315–323, 1976

Hilmas D, Gilette EL: Morphometric analyses of the microvasculature of tumors during growth and after X-irradiation. Cancer 33: 103–110, 1974

Yamaura H, Sato H: Quantitative studies on the developing vascular system of rat hepatoma. J Natl Cancer Inst 53: 1229–1240, 1974

Rous R, Gilding HP, Smith F: A gradient of vascular permeability. J Exp Med 51: 807–830, 1930

Ley K, Arfors KE: Segmental differences of microvascular permeability for FITC-dextrans measured in the hamster cheek pouch. Microvasc Res 31: 84–99, 1986

Dewey WC: Vascular-extravascular exchange of131l plasma proteins in the rat. Am J Physiol 197: 423–431, 1959

Song CW, Levitt SH: Effect of X-irradiation on vascularity of normal tissues and experimental tumor. Radiology 94: 445–447, 1970

Peterson HI, Appelgren L, Lundborg G, Rosengren B: Capillary permeability of two transplantable rat tumors as compared with various normal organs of the rat. Bibl Anat 12: 511–518, 1973

Peterson HI: Vascular and extravascular spaces in tumors: tumor vascular permeability. In: Peterson HI (ed) Tumor Blood Circulation, pp 77–85. Boca Raton, FL: CRC Press, 1979

Groothuis DR, Fischer JM, Pasternak JF, Blasberg RG, Vick NA, Bigner DD: Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. Cancer Res 43: 3368–3373, 1983

Blasberg RG, Kobayashi T, Horowitz M, Rice JM, Groothuis D, Molnar P, Fenstermacher JD: Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors. Ann Neurology 14: 202–215, 1983

Molnar P, Blasberg RG, Groothuis DG, Bigner D, Fenstermacher JF: Regional blood-to-tissue transport in avian sarcoma virus (AVS)-induced brain tumors. Neurology 33: 702–711, 1983

Blasberg R, Molnar P, Groothuis D, Patlak CS, Owens E, Fenstermacher J: Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors: Implications for chemotherapy. J Pharmacol Expt Therap 231: 724–735, 1984

Molnar P, Blasberg RG, Horowitz M, Smith B, Fenstermacher JD: Regional blood-to-tissue transport in RT-g brain tumors. J Neurosurg 58: 874–884, 1983

Blasberg RG, Shapiro WR, Molnar P, Patlak CS, Fenstermacher JD: Local blood-to-tissue transport in Walker 256 metastatic brain tumors. J Neuro-Oncology 2: 205–218, 1984

Song CW, Sung JH, Clement JJ, Levitt SH: Vascular changes in neuroblastoma of mice following X-irradiation. Cancer Res 34: 2344–2350, 1974

Groothuis DR, Fischer JM, Lapin G, Bigner DD, Vick NA: Permeability of different experimental brain tumor models to horseradish peroxidase. J Neuropath Exptl Neurology 41: 164–185, 1982

Ackerman NB, Hechmer PA: Studies on the capillary permeability of experimental liver metastases. Surg Gynec Obstet 146: 884–888, 1978

Rutili G: Transport of macromolecules in subcutaneous tissue by FITC-dextrans. Dissertation, Univ. Upsaliensis, Uppsala, Sweden, 1978

Garlick DG, Renkin EM: Transport of large molecules from plasma to interstitial fluid and lymph in dogs. Amer J Physiol 219: 1595–1605, 1970

Butler TP, Grantham FH, Gullino PM: Bulk transfer of fluid in the interstitial compartment of mammary tumors. Cancer Res 35: 512–516, 1975

Gullino PM: The internal milieu of tumors. Progr Exp Tumor Res 8: 1–25, 1966

Misiewicz M: Microvascular and interstitial pressures in normal and neoplastic tissues. M.S. Thesis, Carnegie Mellon University, 1986

Algire GH, Legallais FY: Vascular reactions of normal and malignant tissuesin vivo. IV. The effect of peripheral hypotension on transplanted tumors. J Natl Cancer Inst 12: 399–421, 1951

Algire GH: Blood pressure measurements and changes in peripheral vascular bed in unanesthetized mice [Abstract]. Federation Proc 8: 349, 1949

Algire GH: Determination of peripheral blood pressure in unanesthetized mice during microscopic observation of blood vessels. J Natl Cancer Inst 14: 865–873, 1954

Ide AD, Baker NH, Warren SH: Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am J Roentgenol 42: 891–899, 1939

Eddy HA, Casarett GW: Development of the vascular system in the hamster malignant neurilemmoma. Microvasc Res 6: 63–82, 1973

Peters W, Teixeira M, Intaglietta M, Gross JF: Microcirculatory studies in rat mammary carcinoma. I. Transparent chamber method, development of microvasculaturem and pressures in tumor vessels. J Natl Cancer Inst 65: 631–642, 1980

Young JS, Griffith HD: The dynamics of parenchymatous embolism in relation to the dissemination of malignant tumors. J Pathol Bacteriol 62: 293–311, 1950

Wiig H: Microvascular pressures in DMBA-induced rat mammary tumors. Scand J Clin Lab Invest 42: 165–171, 1982

Hori K, Suzuki M, Abe S, Saito S, Sato H: A microocclusion technique for measurement of the microvascular pressure in tumor and subcutis. Japn J Cancer Res (Gann) 74: 122–127, 1983

Endrich B, Hammersen F: Morphologic and hemodynamic alterations in capillaries during hyperthermia. In: Anghileri CLJ, Robert J (eds) Hyperthermia in Cancer Treatment, Chapter 2. CRC Press, Boca Raton, FL, 1986

Young JS, Lumsden CE, Stalker AL: The significance of the ‘tissue pressure’ of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. J Path Bact 62: 313–333, 1950

Wiig H, Tveit E, Hultborn R, Reed RK, Weiss L: Interstitial fluid pressure in DMBA-induced rat mammary tumors. Scand J Clin Lab Invest 42: 159–164, 1982

Paskins-Hurlburt AJ, Hollenberg NK, Abrams HL: Tumor perfusion in relation to the rapid growth phase and necrosis: Studies on the Walker carcinoma in the rat testicle. Microvasc Res 24: 15–24, 1982

Hori K, Suzuki M, Abe I, Saito S: Increased tumor pressure in association with the growth of rat tumors. Japan J Cancer Res (Gann) 77: 65–73, 1986

Misiewicz M, Jain RK: Interstitial pressure gradients in VX2 carcinoma. In preparation, 1987

Chary SR, Jain RK: Analysis of diffusive and convective recovery of fluorescence after photobleaching — Effect of uniform flow field. Chemical Engineering Communications (in press), 1987

Potchen EJ, Kinzie J, Curtis C, Siegel BA, Studer RK: Effect of irradiation on tumor microvascular permeability to macromolecules. Cancer 30: 639–642, 1972

Song CW, Levitt SH: Vascular changes in Walker 256 carcinoma of rats following irradiation. Radiology 100: 397–407, 1971

Hahn GM: Hyperthermia and Cancer. Plenum Press, New York, 1982

Jain RK, Gullino PM (eds): Thermal Characteristics of Tumors: Applications in Detection and Treatment. Annals of the New York Academy of Sciences 335, 1980

Sevitt S: Early and delayed edema and increases in capillary permeability after burns of the skin. J Pathol Bact 75: 27–37, 1958

Wilhelm DL, Mason B: Vascular permeability changes in inflammation: The role of endogenous permeability factors in mild thermal injury. Br J Exp Pathol 61: 487–506, 1960

Cotran RS, Remensnyder JP: The structural basis of increased vascular permeability after graded thermal injury - light and electron microscopic studies. Ann N.Y. Acad Sci 150: 495–509, 1968

Arturson G: Microvascular permeability to macromolecules in thermal injury. Acta Physiol Scand Suppl 463: 111–112, 1979

Ackerman NB, Makohon S: The effects of cooling, freezing, and thawing on vascular permeability and perfusion in experimental liver metastases. Surg Gynec Obstet 152: 262–267, 1981

Lefor AT, Makohon S, Ackerman NB: The effects of hyperthermia on vascular permeability in experimental liver metastasis. J Surg Oncol 28: 297–300, 1981

Gerlowski LE, Jain RK: Effect of hyperthermia on microvascular permeability of normal and neoplastic tissues. Intl J Microcirc: Clinical and Expt 4: 336–372, 1985

Svensjö E, Joyner WL: The effects of intermittant and continuous stimulation of microvessels in the cheek pouch of hamsters with histamine and bradykinin on the development of venular leaky sites. J Microcirc Endothel Lymphat 1: 381, 1984

Senger DR, Galli SJ, Dvorak AM, Peruzzi CA, Harvery VS, Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983–985, 1983

Senger DR, Peruzzi CA, Feder J, Dvorak HF: A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46: 5629–5632, 1986

Ackerman NB, Hechmer PA, Makohon S: Failure of histamine type mediators to enhance vascular permeability in experimental liver metastasis. Surg Gynec Obstet 151: 647–651, 1980

Jain RK, Shah SA, Finney PL: Continuous non-invasive monitoring of pH and temperature in rat Walker 256 carcinoma during normo-and hyperglycemia. J Natl Cancer Inst 73: 429–436, 1984

Ward-Hartley K, Jain RK: Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits. Cancer Res 47: 371–377, 1987

Ward KA, Jain RK: Physiological response on tumors to hyperglycemia: Characterization, significance, and role in hyperthermia. International Journal of Hyperthermia, (in press)

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Cancer and Metastasis Reviews

Tập 6

559-593

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