Transfusional hemosiderosis and combined chelation therapy in sickle thalassemia

European Journal of Haematology - Tập 75 Số 4 - Trang 355-358 - 2005
Maria Tsironi1, Katerina Polonifi1, Spyros Deftereos1, Dimitrios Farmakis1, Panagiotis Andriopoulos1, Ioannis Moyssakis1, Athanasios Aessopos1
1First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece

Tóm tắt

Abstract:  Although the indications for transfusions in sickle cell syndromes are well listed, and chronic transfusion has become practicable since the recent advances in chelation therapy have essentially eliminated the risk of secondary iron overload, multi‐transfused, non‐compliant to long‐term chelation therapy patients confront the complication of iron overload and secondary hemosiderosis. In thalassemia major patients, combined therapy with desferrioxamine and deferiprone has maximized tissue iron removal and may reduce the overall occurrence of hemosiderotic heart failure. Despite this, safety and contradictions of chelating agents are still controversial. The aim of this report is to present the results of this combination in a long‐term transfused sickle β‐thalassemic patient suffering from severe heart failure and liver dysfunction.

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Thông tin
Thông tin xuất bản

European Journal of Haematology

Tập 75 Số 4

355-358

Thông tin tác giả