Transfusion-related acute lung injury (TRALI) after intravenous immunoglobulins: French multicentre study and literature review
Tóm tắt
Transfusion-related acute lung injury (TRALI), defined as the onset of acute respiratory distress after blood transfusion, is a rare complication which is a leading cause of transfusion related-mortality. In this retrospective study, we report the French nationwide experience of intravenous immunoglobulin (IVIG)-related TRALI, with a literature review and analysis of management and outcome of this rare condition. With the pharmacovigilance services, we conducted a retrospective multicenter study in the French network of intensive care units with TRALI concomitant to IVIG use and pooled with data from a literature review. Overall, 17 cases have been included in this case-series, our case report, seven personal cases and nine cases from the literature review. The median age was 55 years [2–79] with 10/17 (59%) male subjects. The underlying diseases motivating IVIG infusion were neurologic diseases in 35% of cases (Guillain Barre syndrome = 2, peripheral neuropathy = 2, neurolupus = 1, myasthenia = 1), multiple myeloma with hypogammaglobulinemia (n = 2; 12%), primary hypogammaglobulinemia (n = 2; 12%), autoimmune cytopenias (n = 2; 12%), graft versus host cutaneous disease after allogeneic hematopoietic stem cell transplantation for acute myeloid leukaemia (n = 1), anti-HLA antibodies after lung transplant (n = 1), cancer-associated thrombotic thrombocytopenic purpura-haemolytic uremic syndrome (n = 1), Kawasaki disease (n = 1) and in experimental essay (n = 1). TRALI symptoms begin either after the start or during the infusion (n = 7; 41%), or after the infusion (n = 10; 59%, 10 min to 24 h). Besides respiratory distress, it was also noted shock (33%), fever (18 %), cough (18%), nausea/vomiting (18 %), chills (12%) and agitation (12%). The X-ray showed mainly bilateral alveolar opacities (n = 15; 88%). Mechanical ventilation was needed in nine cases (53%), with median 1-day duration [1–4]. Four patients (24%) died during hospitalisation in the intensive care unit. Given the increasing use of intravenous immunoglobulins, TRALI must now be discussed in cases of respiratory distress occurring during or immediately following the infusion even if this side effect remains rare.
Tài liệu tham khảo
Vlaar AP, Juffermans NP (2013) Transfusion-related acute lung injury: a clinical review. Lancet 382:984–994
Kleinman S, Caulfield T, Chan P, Davenport R, McFarland J, McPhedran S, Meade M, Morrison D, Pinsent T, Robillard P, Slinger P (2004) Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion 44:1774–1789
Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D (2005) National Heart, Lung and Blood Institute Working Group on TRALI. Transfusion-related acute lung injury: definition and review. Crit Care Med 33:721–726
Sayah DM, Looney MR, Toy P (2012) Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment and prevention of transfusion related acute lung injury (TRALI). Crit Care Clin 28:363–372
Toy P, Kleinman SH, Looney MR (2017) Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion 57(3):709–713
Silliman C, Paterson A, Dickey W et al (1997) The association of biologically active lipids with the development of transfusion related acute lung injury : a retrospective study. Transfusion 37:719–726
Dry S, Bechard K, Milford E, Curchill W, Benjamin R (1999) Pathology of transfusion related acute lung injury. Am J Clin Pathol 112(2):216–221
Kumar R, Sedky MJ, Varghese SJ, Sharawy OE (2016) Transfusion related acute injury (TRALI): a single institution experience of 15 years. Indian J Hematol Blood Transfus 32:320–327
Popovsky MA, Moore SB (1985) Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion 25:573–577
Looney M, Su X, Van Ziffe J, Lowell C, Mathay M (2006) Neutrophils and their fc gamma receptors are essential in a mouse model of transfusion related acute lung injury. J Clin Invest 116:1615–1623
Eastlund T, McGarth P, Britten A et al (1989) Fatal pulmonary transfusion reaction to plasma containing donor HLA antibody. Vox Sang 57:42–45
Densmore T, Goodnough L, Ali S et al (1999) Prevalence of HLA sensitization in female apheresis donors. Transfusion 39:103–106
Silliman C, Voelkel N, Allard J et al (1998) Plasma and lipids from stored packed red cells cause acute lung injury in animal model. J Clin Invest 101:1458–1469
Christopher C, Silliman C, Ernest E, Moore M, Kehler A (2011) and al. Identification of lipids that accumulate during the routine storage of prestoragfe leukoreduced red blood cells and cause acute lung injury. Transfusion 51(12):2549–2554
Suassuna JH, da Costa MA, Faria RA, Melichar AC (1997) Non cardiogenic pulmonary edema triggered by intravenous immunoglobulin in cancer-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Nephron 77(3):368–370
Rizk A, Gorson KC, Kenney L, Weinstein R (2001) Transfusion-related acute lung injury after the infusion of IVIG. Transfusion 41:264–268
Voulgari PV, Paschou S, Svarna E, Tsifetaki N, Drosos AA (2010) Images in rheumatology. Transfusion-related acute lung injury during intravenous immunoglobulin treatment. J Rheumatol 37:190–191
Gupta V, Gupta P, Yadaz TP (2011) Transfusion related acute lung injury with intravenous immunoglobulin. Indian Pediatr 48(10):807–808
Stoclin A, Delbos F, Dauriat G, Brugiere O, Boeri N, Metivier AC (2013) and al. Transfused-related acute lung injury after intravenous immunoglobulin treatment in a lung transplant recipient. Vox Sang 104(2):175–178
Quest GR, Gaal H, Clarke G, Nahirniak S (2014) Transfusion-related acute lung injury after transfusion of pooled immune globulin: a case report. Transfusion 54:3088–3091
Reddy DR, Guru PK, Blessing MM, Stubbs JR, Rabinstein AA, Wijdicks EF (2015) Transfusion-related acute lung injury after IVIG for myasthenic crisis. Neurocrit Care 23(2):259–261
Dooren MC, Ouwehand WH, Verhoeven AJ, von dem Borne AE, Kuijpers RW (1998) Adult respiratory distress syndrome after experimental intravenous gamma-globulin concentrate and monocyte-reactive IgG antibodies. Lancet 14(352):1601–1602
Ibrahim J, Al Amri A, Ghatasheh G (2017) Transfusion-related acute lung injury after immunoglobulin infusion for kawasaki disease: a case report and literature review. Glob Pediatr Health 19:1–4
Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA (2012) TRALI study group. Transfusion related acute lung injury: incidence and risk factors. Blood 119:1757–1767
Goligher EC, Cserti-Gazdewich C, Balter M, Gupta V, Brandwein JE (2009) Acute lung injury during antithymocyte globulin therapy for aplastic anemia. Can Respir J 16:e3–e5
Silliman CC, Boshkov LK, Mehdizadehkashi Z, Elzi DJ, Dickey WO, Podlosky L, Clarke G, Ambruso DR (2003) Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors. Blood 101:454–462
Gajic O, Rana R, Winters JL, Yilmaz M, Mendez JL, Rickman OB, O'Byrne MM, Evenson LK, Malinchoc M, DeGoey SR, Afessa B, Hubmayr RD, Moore SB (2007) Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med 176:886–891
Vlaar AP, Binnekade JM, Prins D, van Stein D, Hofstra JJ, Schultz MJ, Juffermans NP (2010) Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med 38:771–778
Benson AB, Moss M, Silliman CC (2009) Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically ill. Br J Haematol 147:431–433
Benson AB, Austin GL, Berg M, McFann KK, Thomas S, Ramirez G, Rosen H, Silliman CC, Moss M (2010) Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding. Intensive Care Med 36:1710–1717
Vlaar AP, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Kulik W, Korevaar J, de Mol BA, Koopman MM, Porcelijn L, Binnekade JM, Vroom MB, Schultz MJ, Juffermans NP (2011) The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. Blood 117:4218–4225
Semple JW, Kim M, Hou J, McVey M, Lee YJ, Tabuchi A, Kuebler WM, Chai ZW, Lazarus AH (2012) Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production. PLoS One 7(2):e31357
Fung YL, Kim M, Tabuchi A, Aslam R, Speck ER, Chow L, Kuebler WM, Freedman J, Semple JW (2010) Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury. Blood
Suassuna JH, da Costa MA, Faria RA, Melichar AC (1997) Noncardiogenic pulmonary edema triggered by intravenous immunoglobulin in cancer-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Nephron. 77(3):368–370