Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

Anselmo, 2014, An Overview of Clinical and Commercial Impact of Drug Delivery Systems, J. Control. Release, 190, 15, 10.1016/j.jconrel.2014.03.053

Han, 2015, Potential of Combined Ultrasound and Microneedles for Enhanced Transdermal Drug Permeation: A Review, Eur. J. Pharm. Biopharm., 89, 312, 10.1016/j.ejpb.2014.12.020

Brambilla, 2014, Breakthrough Discoveries in Drug Delivery Technologies: The Next 30 years, J. Control. Release, 190, 9, 10.1016/j.jconrel.2014.03.056

Ita, 2014, Transdermal Drug Delivery: Progress and Challenges, J. Drug Deliv. Sci. Technol., 24, 245, 10.1016/S1773-2247(14)50041-X

Schoellhammer, 2014, Skin Permeabilization for Transdermal Drug Delivery: Recent Advances and Future Prospects, Expert Opin. Drug Deliv., 11, 393, 10.1517/17425247.2014.875528

McCrudden, 2013, Strategies for Enhanced Peptide and Protein Delivery, Ther. Deliv., 4, 593, 10.4155/tde.13.31

Kermode, 2004, Unsafe Injections in Low-Income Country Health Settings: Need for Injection Safety Promotion to Prevent the Spread of Blood-Borne Viruses, Health Promot. Int., 19, 95, 10.1093/heapro/dah110

Donnelly, R.F., Singh, T.R.R., Morrow, D.I., and Woolfson, A.D. (2012). Microneedle-Mediated Transdermal and Intradermal Drug Delivery, Wiley.

Kretsos, 2007, A Geometrical Model of Dermal Capillary Clearance, Math. Biosci., 208, 430, 10.1016/j.mbs.2006.10.012

Donnelly, 2012, Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery, Adv. Funct. Mater., 22, 4879, 10.1002/adfm.201200864

Arora, 2008, Micro-Scale Devices for Transdermal Drug Delivery, Int. J. Pharm., 364, 227, 10.1016/j.ijpharm.2008.08.032

McCrudden, 2013, Microneedles for Intradermal and Transdermal Drug Delivery, Eur. J. Pharm. Sci., 50, 623, 10.1016/j.ejps.2013.05.005

Prausnitz, 2008, Transdermal Drug Delivery, Nat. Biotechnol., 26, 1261, 10.1038/nbt.1504

Suh, 2014, Microneedle Patches for Vaccine Delivery, Clin. Exp. Vaccine Res., 3, 42, 10.7774/cevr.2014.3.1.42

Peasah, 2013, Influenza Cost and Cost-Effectiveness Studies globally—A Review, Vaccine, 31, 5339, 10.1016/j.vaccine.2013.09.013

Menon, 2002, New Insights into Skin Structure: Scratching the Surface, Adv. Drug Deliv. Rev., 54, S3, 10.1016/S0169-409X(02)00121-7

Liu, 2014, Using Skin for Drug Delivery and Diagnosis in the Critically Ill, Adv. Drug Deliv. Rev., 77, 40, 10.1016/j.addr.2014.10.004

Williams, 2012, Penetration Enhancers, Adv. Drug Deliv. Rev., 64, 128, 10.1016/j.addr.2012.09.032

Benson, H.A., and Watkinson, A.C. (2012). Topical and Transdermal Drug Delivery: Principles and Practice, Wiley.

Gratieri, 2013, Next Generation Intra-and Transdermal Therapeutic Systems: Using Non-and Minimally-Invasive Technologies to Increase Drug Delivery into and Across the Skin, Eur. J. Pharm. Sci., 50, 609, 10.1016/j.ejps.2013.03.019

Lambert, 2008, Intradermal Vaccine Delivery: Will New Delivery Systems Transform Vaccine Administration?, Vaccine, 26, 3197, 10.1016/j.vaccine.2008.03.095

Jiskoot, 2012, Microneedle Technologies for (Trans) Dermal Drug and Vaccine Delivery, J. Control. Release, 161, 645, 10.1016/j.jconrel.2012.01.042

Domínguez-Delgado, C.L., Rodríguez-Cruz, I.M., López-Cervantes, M., Escobar-Chávez, J., and Merino, V. (2010). The Skin a Valuable Route for Administration of Drugs. Current Technologies to Increase the Transdermal Delivery of Drugs, Bentham Science.

Barry, 2008, Liposomes and Skin: From Drug Delivery to Model Membranes, Eur. J. Pharm. Sci., 34, 203, 10.1016/j.ejps.2008.05.002

Walters, K.A. (2002). Dermatological and Transdermal Formulations, CRC Press.

Alexander, 2012, Approaches for Breaking the Barriers of Drug Permeation through Transdermal Drug Delivery, J. Control. Release, 164, 26, 10.1016/j.jconrel.2012.09.017

Sherwood, 2007, Age Moderates the Short-Term Effects of Transdermal 17β-Estradiol on Endothelium-Dependent Vascular Function in Postmenopausal Women, Arterioscler. Thromb. Vasc. Biol., 27, 1782, 10.1161/ATVBAHA.107.145383

McLennan, 2005, Subcutaneous Drug Delivery and the Role of the Lymphatics, Drug Discov. Today Technol., 2, 89, 10.1016/j.ddtec.2005.05.006

Schuetz, 2005, Emerging Strategies for the Transdermal Delivery of Peptide and Protein Drugs, Expert Opin. Drug Deliv., 2, 533, 10.1517/17425247.2.3.533

Shahzad, 2015, Breaching the Skin Barrier through Temperature Modulations, J. Control. Release, 202, 1, 10.1016/j.jconrel.2015.01.019

Dhote, 2012, Iontophoresis: A Potential Emergence of a Transdermal Drug Delivery System, Sci. Pharm., 80, 1, 10.3797/scipharm.1108-20

Dragicevic, N., and Maibach, H.I. (2015). Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Drug Manipulation Strategies and Vehicle Effects, Springer.

Subramony, 2013, Needle Free Parenteral Drug Delivery: Leveraging active transdermal technologies for pediatric use, Int. J. Pharm., 455, 14, 10.1016/j.ijpharm.2013.07.055

Wiedersberg, 2014, Transdermal Drug Delivery: 30 Years of War and Still Fighting!, J. Control. Release, 190, 150, 10.1016/j.jconrel.2014.05.022

Ghosh, T.K., and Jasti, B.R. (2004). Theory and Practice of Contemporary Pharmaceutics, CRC press.

Choy, 2011, The Rule of Five for Non-Oral Routes of Drug Delivery: Ophthalmic, Inhalation and Transdermal, Pharm. Res., 28, 943, 10.1007/s11095-010-0292-6

Lipinski, 2012, Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings, Adv. Drug Deliv. Rev., 64, 4, 10.1016/j.addr.2012.09.019

Barry, 2001, Novel Mechanisms and Devices to Enable Successful Transdermal Drug Delivery, Eur. J. Pharm. Sci., 14, 101, 10.1016/S0928-0987(01)00167-1

Park, 2014, Sonophoresis in Transdermal Drug Deliverys, Ultrasonics, 54, 56, 10.1016/j.ultras.2013.07.007

Naik, 2000, Transdermal Drug Delivery: Overcoming the skin’s Barrier Function, Pharm. Sci. Technol. Today, 3, 318, 10.1016/S1461-5347(00)00295-9

Chen, 2006, Transdermal Protein Delivery by a Coadministered Peptide Identified Via Phage Display, Nat. Biotechnol., 24, 455, 10.1038/nbt1193

Williams, 2006, Can drug-bearing Liposomes Penetrate Intact Skin?, J. Pharm. Pharmacol., 58, 415

Rehman, 2013, Recent Advances in Gel Technologies for Topical and Transdermal Drug Delivery, Drug Dev. Ind. Pharm., 40, 433, 10.3109/03639045.2013.828219

Zorec, 2013, Active Enhancement Methods for Intra-and Transdermal Drug Delivery: A Review, Zdravniški Vestnik, 82, 339

Paudel, 2010, Challenges and Opportunities in dermal/transdermal Delivery, Ther. Deliv., 1, 109, 10.4155/tde.10.16

Marianecci, 2014, Niosomes from 80s to Present: The State of the Art, Adv. Colloid Interface Sci., 205, 187, 10.1016/j.cis.2013.11.018

Karande, 2009, Enhancement of Transdermal Drug Delivery via Synergistic Action of Chemicals, Biochim. Biophys. Acta Biomembr., 1788, 2362, 10.1016/j.bbamem.2009.08.015

Mitragotri, 2013, Devices for Overcoming Biological Barriers: The use of physical forces to disrupt the barriers, Adv. Drug Deliv. Rev., 65, 100, 10.1016/j.addr.2012.07.016

Lee, 2011, Microsecond Thermal Ablation of Skin for Transdermal Drug Delivery, J. Control. Release, 154, 58, 10.1016/j.jconrel.2011.05.003

Azagury, 2014, Ultrasound Mediated Transdermal Drug Delivery, Adv. Drug Deliv. Rev., 72, 127, 10.1016/j.addr.2014.01.007

Zhang, 2014, Microneedle-Assisted Microparticle Delivery by Gene Guns: Experiments and Modeling on the Effects of Particle Characteristics, Drug Deliv., 22, 1, 10.3109/10717544.2014.960982

Katsumi, 2012, Development of a Novel self-dissolving Microneedle Array of Alendronate, a nitrogen-containing Bisphosphonate: Evaluation of Transdermal Absorption, Safety, and Pharmacological Effects After Application in Rats, J. Pharm. Sci., 101, 3230, 10.1002/jps.23136

Simonin, 1995, On the Mechanisms of in Vitro and in Vivo Phonophoresis, J. Control. Release, 33, 125, 10.1016/0168-3659(94)00075-6

Skauen, 1984, Phonophoresis, Int. J. Pharm., 20, 235, 10.1016/0378-5173(84)90171-6

Polat, 2011, Ultrasound-Mediated Transdermal Drug Delivery: Mechanisms, Scope, and Emerging Trends, J. Control. Release, 152, 330, 10.1016/j.jconrel.2011.01.006

Singer, 1998, Low-frequency Sonophoresis: Pathologic and Thermal Effects in Dogs, Acad. Emerg. Med., 5, 35, 10.1111/j.1553-2712.1998.tb02572.x

Adamo, 2013, Microfluidic Jet Injection for Delivering Macromolecules into Cells, J. Micromech. Microeng., 23, 35026, 10.1088/0960-1317/23/3/035026

Lakshmanan, 2014, Physical Energy for Drug Delivery; Poration, Concentration and Activation, Adv. Drug Deliv. Rev., 71, 98, 10.1016/j.addr.2013.05.010

Neumann, 1982, Gene Transfer into Mouse Lyoma Cells by Electroporation in High Electric Fields, EMBO J., 1, 841, 10.1002/j.1460-2075.1982.tb01257.x

Preat, 2002, Skin Electroporation for Transdermal and Topical Drug Delivery, Transdermal Drug Deliv., 123, 227, 10.1201/9780203909683-6

Denet, 2003, Transdermal Delivery of Timolol by Electroporation through Human Skin, J. Control. Release, 88, 253, 10.1016/S0168-3659(03)00010-5

Prausnitz, 1993, Electroporation of Mammalian Skin: A Mechanism to Enhance Transdermal Drug Delivery, Proc. Natl. Acad. Sci. USA, 90, 10504, 10.1073/pnas.90.22.10504

Prausnitz, 1995, Transdermal Delivery of Heparin by Skin Electroporation, Biotechnology, 13, 1205

Bommannan, 1994, Effect of Electroporation on Transdermal Lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH) in Vitro, Pharm. Res., 11, 1809, 10.1023/A:1018983804635

Chang, 2000, The Effect of Electroporation on Iontophoretic Transdermal Delivery of Calcium Regulating Hormones, J. Control. Release, 66, 127, 10.1016/S0168-3659(99)00262-X

Lombry, 2000, Transdermal Delivery of Macromolecules using Skin Electroporation, Pharm. Res., 17, 32, 10.1023/A:1007510323344

Yi, J., Barrow, A.J., Yu, N., and O'Neill, B.E. (2013). Efficient Electroporation of Liposomes Doped with Pore Stabilizing Nisin. J. Liposome Res., 1–6.

Badkar, 2002, Electrically Enhanced Transdermal Delivery of a Macromolecule, J. Pharm. Pharmacol., 54, 907, 10.1211/002235702760089018

Kotzki, 2015, Effect of Continuous Vs Pulsed Iontophoresis of Treprostinil on Skin Blood Flow, Eur. J. Pharm. Sci., 72, 21, 10.1016/j.ejps.2015.02.012

Gratieri, 2013, Mathematical Models to Describe Iontophoretic Transport in Vitro and in Vivo and the Effect of Current Application on the Skin Barrier, Adv. Drug Deliv. Rev., 65, 315, 10.1016/j.addr.2012.04.012

Toyoda, 2015, Anti-Cancer Vaccination by Transdermal Delivery of Antigen Peptide-Loaded Nanogels via Iontophoresis, Int. J. Pharm., 483, 110, 10.1016/j.ijpharm.2015.02.024

Dixit, 2007, Iontophoresis—An Approach for Controlled Drug Delivery: A Review, Curr. Drug Deliv., 4, 1

Khan, 2011, Iontophoretic Drug Delivery: History and Applications, J. Appl. Pharm. Sci., 1, 11

Miller, L.L., Blankespoor, R.L., and Zinger, B. (1986). Electrochemical controlled release drug delivery system. (4585652 A), U.S. Patent.

Green, 1991, Lontophoretic Delivery of Amino Acids and Amino Acid Derivatives Across the Skin in Vitro, Pharm. Res., 8, 1113, 10.1023/A:1015894016235

Green, 1992, Transdermal Iontophoresis of Amino Acids and Peptides in Vitro, J. Control. Release, 21, 187, 10.1016/0168-3659(92)90020-R

Burnette, 1987, Characterization of the Permselective Properties of Excised Human Skin during Iontophoresis, J. Pharm. Sci., 76, 765, 10.1002/jps.2600761003

Hueber, 1996, Iontophoresis of Bases, Nucleosides, and Nucleotides, Pharm. Res., 13, 553, 10.1023/A:1016041904037

Banga, A.K. (1998). Electrically Assisted Transdermal and Topical Drug Delivery, Taylor & Francis.

Roustit, 2014, Cutaneous Iontophoresis of Treprostinil in Systemic Sclerosis: A Proof-of-Concept Study, Clin. Pharmacol. Ther., 95, 439, 10.1038/clpt.2013.255

Pillai, 2004, Transdermal Iontophoresis of Insulin: IV. Influence of Chemical Enhancers, Int. J. Pharm., 269, 109, 10.1016/j.ijpharm.2003.09.032

Naik, 2007, Transdermal Delivery of Cytochrome C—A 12.4 kDa protein—across Intact Skin by constant–current Iontophoresis, Pharm. Res., 24, 1360, 10.1007/s11095-007-9294-4

Gratieri, 2014, Targeted Local Simultaneous Iontophoresis of Chemotherapeutics for Topical Therapy of Head and Neck Cancers, Int. J. Pharm., 460, 24, 10.1016/j.ijpharm.2013.10.053

Dubey, 2010, Non-Invasive Iontophoretic Delivery of Enzymatically Active Ribonuclease A (13.6 kDa) Across Intact Porcine and Human Skins, J. Control. Release, 145, 203, 10.1016/j.jconrel.2010.04.020

Dubey, 2011, Non-Invasive Electrically-Assisted Transdermal Delivery of Human Basic Fibroblast Growth Factor, Mol. Pharm., 8, 1322, 10.1021/mp200125j

Dubey, 2014, Understanding the Poor Iontophoretic Transport of Lysozyme across the Skin: When High Charge and High Electrophoretic Mobility are not enough, J. Control. Release, 183, 35, 10.1016/j.jconrel.2014.03.027

LeGrys, 2007, Diagnostic Sweat Testing: The Cystic Fibrosis Foundation Guidelines, J. Pediatr., 151, 85, 10.1016/j.jpeds.2007.03.002

Sun, 2014, Carbon Nanotube Composites for Glucose Biosensor Incorporated with Reverse Iontophoresis Function for Noninvasive Glucose Monitoring, Inter. J. Nanomed., 9, 3069

Krueger, 2014, Iontophoresis: Principles and Applications, Fisioterapia Movimento, 27, 469, 10.1590/0103-5150.027.003.AR02

Kalia, 2004, Iontophoretic Drug Delivery, Adv. Drug Deliv. Rev., 56, 619, 10.1016/j.addr.2003.10.026

Mitragotri, 2006, Current Status and Future Prospects of Needle-Free Liquid Jet Injectors, Nat. Rev. Drug Discov., 5, 543, 10.1038/nrd2076

Stachowiak, 2009, Dynamic Control of Needle-Free Jet Injection, J. Control. Release, 135, 104, 10.1016/j.jconrel.2009.01.003

Mitragotri, 2005, Immunization without Needles, Nat. Rev. Immunol., 5, 905, 10.1038/nri1728

Arora, 2007, Needle-Free Delivery of Macromolecules Across the Skin by Nanoliter-Volume Pulsed Microjets, Proc. Natl. Acad. Sci. USA, 104, 4255, 10.1073/pnas.0700182104

Kelly, 2008, Preventing Contamination between Injections with Multiple-use Nozzle Needle-Free Injectors: A Safety Trial, Vaccine, 26, 1344, 10.1016/j.vaccine.2007.12.041

Cassaday, 2007, A Phase I Study of Immunization using Particle-Mediated Epidermal Delivery of Genes for gp100 and GM-CSF into Uninvolved Skin of Melanoma Patients, Clin. Cancer Res., 13, 540, 10.1158/1078-0432.CCR-06-2039

Sarno, 2000, Clinical Immunogenicity of Measles, Mumps and Rubella Vaccine Delivered by the Injex Jet Injector: Comparison with Standard Syringe Injection, Pediatr. Infect. Dis. J., 19, 839, 10.1097/00006454-200009000-00006

Jackson, 2001, Safety and Immunogenicity of Varying Dosages of Trivalent Inactivated Influenza Vaccine Administered by Needle-Free Jet Injectors, Vaccine, 19, 4703, 10.1016/S0264-410X(01)00225-0

Kendall, 2004, Intradermal Ballistic Delivery of Micro-Particles into Excised Human Skin for Pharmaceutical Applications, J. Biomech., 37, 1733, 10.1016/j.jbiomech.2004.01.032

Hussain, 2014, Potential Enhancers for Transdermal Drug Delivery: A Review, Inter. J. Basic Med. Sci. Pharm., 4, 19

Sklar, 2014, Laser Assisted Drug Delivery: A Review of an Evolving Technology, Lasers Surg. Med., 46, 249, 10.1002/lsm.22227

Giannos, 2014, Skin Microporation: Strategies to Enhance and Expand Transdermal Drug Delivery, J. Drug Deliv. Sci. Technol., 24, 293, 10.1016/S1773-2247(14)50048-2

Brown, M.B., Traynor, M.J., Martin, G.P., and Akomeah, F.K. (2008). Drug Delivery Systems, Springer.

Gomez, 2008, Laser Treatments on Skin Enhancing and Controlling Transdermal Delivery of 5-fluorouracil, Lasers Surg. Med., 40, 6, 10.1002/lsm.20590

Nelson, 1991, Mid-Infrared Laser Ablation of Stratum Corneum Enhances in Vitro Percutaneous Transport of Drugs, J. Investig. Dermatol., 97, 874, 10.1111/1523-1747.ep12491600

Baron, 2003, Laser-Assisted Penetration of Topical Anesthetic in Adults, Arch. Dermatol., 139, 1288, 10.1001/archderm.139.10.1288

Dhamecha, 2010, Physical Approaches to Penetration Enhancement, Inter. J. Health Res., 3, 57

Kumar, 2007, Modified Transdermal Technologies: Breaking the Barriers of Drug Permeation via the Skin, Trop. J. Pharm. Res., 6, 633, 10.4314/tjpr.v6i1.14641

Wang, 2004, Erbium: YAG Laser Pretreatment Accelerates the Response of Bowen’s Disease Treated by Topical 5-Fluorouracil, Dermatol. Surg., 30, 441

Lin, 2014, Lasers as an Approach for Promoting Drug Delivery via Skin, Expert Opin. Drug Deliv., 11, 599, 10.1517/17425247.2014.885501

Hong, 2014, Hydrogel Microneedle Arrays for Transdermal Drug Delivery, Nano-Micro Lett., 6, 191, 10.1007/BF03353783

Indermun, 2014, Current Advances in the Fabrication of Microneedles for Transdermal Delivery, J. Control. Release, 185, 130, 10.1016/j.jconrel.2014.04.052

Lademann, 2009, The Tape Stripping procedure—Evaluation of some Critical Parameters, Eur. J. Pharm. Biopharm., 72, 317, 10.1016/j.ejpb.2008.08.008

2008, The Tape-Stripping Technique as a Method for Drug Quantification in Skin, J. Pharm. Pharm. Sci., 11, 104, 10.18433/J3201Z

Liu, 2014, Transdermal Delivery of Relatively High Molecular Weight Drugs using Novel Self-Dissolving Microneedle Arrays Fabricated from Hyaluronic Acid and their Characteristics and Safety after Application to the Skin, Eur. J. Pharm. Biopharm., 86, 267, 10.1016/j.ejpb.2013.10.001

Nayak, A., Babla, H., Han, T., and Das, D.B. (2014). Lidocaine Carboxymethylcellulose with Gelatine Co-Polymer Hydrogel Delivery by Combined Microneedle and Ultrasound. Drug Deliv.

McAllister, 2003, Microfabricated Needles for Transdermal Delivery of Macromolecules and Nanoparticles: Fabrication Methods and Transport Studies, Proc. Natl. Acad. Sci. USA, 100, 13755, 10.1073/pnas.2331316100

Yung, 2012, Sharp Tipped Plastic Hollow Microneedle Array by Microinjection Moulding, J. Micromech. Microeng., 22, 015016, 10.1088/0960-1317/22/1/015016

Park, 2005, Biodegradable Polymer Microneedles: Fabrication, Mechanics and Transdermal Drug Delivery, J. Control. Release, 104, 51, 10.1016/j.jconrel.2005.02.002

Pattani, 2012, Microneedle Mediated Intradermal Delivery of Adjuvanted Recombinant HIV-1 CN54gp140 Effectively Primes Mucosal Boost Inoculations, J. Control. Release, 162, 529, 10.1016/j.jconrel.2012.07.039

Gomaa, 2012, Laser-Engineered Dissolving Microneedles for Active Transdermal Delivery of Nadroparin Calcium, Eur. J. Pharm. Biopharm., 82, 299, 10.1016/j.ejpb.2012.07.008

Ito, 2012, Two-Layered Dissolving Microneedles Formulated with Intermediate-Acting Insulin, Int. J. Pharm., 436, 387, 10.1016/j.ijpharm.2012.06.047

Kim, 2012, Microneedles for Drug and Vaccine Delivery, Adv. Drug Deliv. Rev., 64, 1547, 10.1016/j.addr.2012.04.005

McCrudden, 2014, Design and Physicochemical Characterisation of Novel Dissolving Polymeric Microneedle Arrays for Transdermal Delivery of High Dose, Low Molecular Weight Drugs, J. Control. Release, 180, 71, 10.1016/j.jconrel.2014.02.007

Gill, 2008, Effect of Microneedle Design on Pain in Human Subjects, Clin. J. Pain, 24, 585, 10.1097/AJP.0b013e31816778f9

Ameri, 2014, Human Growth Hormone Delivery with a Microneedle Transdermal System: Preclinical Formulation, Stability, Delivery and PK of Therapeutically Relevant Doses, Pharmaceutics, 6, 220, 10.3390/pharmaceutics6020220

Donnelly, 2013, Hydrogel-Forming Microneedle Arrays Exhibit Antimicrobial Properties: Potential for Enhanced Patient Safety, Int. J. Pharm., 451, 76, 10.1016/j.ijpharm.2013.04.045

Sullivan, 2010, Dissolving Polymer Microneedle Patches for Influenza Vaccination, Nat. Med., 16, 915, 10.1038/nm.2182

Norman, 2014, Microneedle Patches: Usability and Acceptability for Self-Vaccination Against Influenza, Vaccine, 32, 1856, 10.1016/j.vaccine.2014.01.076

Nicolas, 2008, Intradermal, Epidermal and Transcutaneous Vaccination: From Immunology to Clinical Practice, Expert Rev. Vaccine, 7, 1201, 10.1586/14760584.7.8.1201

Donnelly, 2014, Hydrogel-Forming Microneedle Arrays can be Effectively Inserted in Skin by Self-Application: A Pilot Study Centred on Pharmacist Intervention and a Patient Information Leaflet, Pharm. Res., 31, 1989, 10.1007/s11095-014-1301-y

Laurent, 2007, Evaluation of the Clinical Performance of a New Intradermal Vaccine Administration Technique and Associated Delivery System, Vaccine, 25, 8833, 10.1016/j.vaccine.2007.10.020

Daddona, 2011, Parathyroid Hormone (1–34)-Coated Microneedle Patch System: Clinical Pharmacokinetics and Pharmacodynamics for Treatment of Osteoporosis, Pharm. Res., 28, 159, 10.1007/s11095-010-0192-9

Zhang, 2012, Development of Lidocaine-Coated Microneedle Product for Rapid, Safe, and Prolonged Local Analgesic Action, Pharm. Res., 29, 170, 10.1007/s11095-011-0524-4

Donnelly, 2010, Microneedle-Based Drug Delivery Systems: Microfabrication, Drug Delivery, and Safety, Drug Deliv., 17, 187, 10.3109/10717541003667798

Watanabe, 2014, Evaluation of the Effect of Polymeric Microneedle Arrays of Varying Geometries in Combination with a High-Velocity Applicator on Skin Permeability and Irritation, Biomed. Microdevices, 16, 591, 10.1007/s10544-014-9861-5

Wang, 2015, Investigation on Fabrication Process of Dissolving Microneedle Arrays to Improve Effective Needle Drug Distribution, Eur. J. Pharm. Sci., 66, 148, 10.1016/j.ejps.2014.09.011

Yang, 2012, A Scalable Fabrication Process of Polymer Microneedles, Inter. J. Nanomed., 7, 1415

Donnelly, 2011, Design and Physicochemical Characterisation of Optimised Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique, Pharm. Res., 28, 41, 10.1007/s11095-010-0169-8

Ashraf, 2012, Optimization of Fabrication Process for MEMS Based Microneedles using ICP Etching Technology, Adv. Mater. Res., 403, 4611

Gardeniers, 2003, Silicon Micromachined Hollow Microneedles for Transdermal Liquid Transport, Microelectromech. Syst., 12, 855, 10.1109/JMEMS.2003.820293

Martanto, 2006, Microinfusion using Hollow Microneedles, Pharm. Res., 23, 104, 10.1007/s11095-005-8498-8

Gupta, 2009, Minimally Invasive Insulin Delivery in Subjects with Type 1 Diabetes using Hollow Microneedles, Diabetes Technol. Ther., 11, 329, 10.1089/dia.2008.0103

Amirouche, 2009, Current Micropump Technologies and their Biomedical Applications, Microsyst. Technol., 15, 647, 10.1007/s00542-009-0804-7

Bariya, 2012, Microneedles: An Emerging Transdermal Drug Delivery System, J. Pharm. Pharmacol., 64, 11, 10.1111/j.2042-7158.2011.01369.x

Gill, 2007, Coated Microneedles for Transdermal Delivery, J. Control. Release, 117, 227, 10.1016/j.jconrel.2006.10.017

Choi, 2012, Stability of Influenza Vaccine Coated onto Microneedles, Biomaterials, 33, 3756, 10.1016/j.biomaterials.2012.01.054

Vrdoljak, 2012, Coated Microneedle Arrays for Transcutaneous Delivery of Live Virus Vaccines, J. Control. Release, 159, 34, 10.1016/j.jconrel.2011.12.026

Demir, Y.K., Akan, Z., and Kerimoglu, O. (2013). Sodium Alginate Microneedle Arrays Mediate the Transdermal Delivery of Bovine Serum Albumin. PLoS ONE.

Kolli, 2012, Microneedle Assisted Iontophoretic Transdermal Delivery of Prochlorperazine Edisylate, Drug Dev. Ind. Pharm., 38, 571, 10.3109/03639045.2011.617753

Singh, 2013, Controlled Delivery of Ropinirole Hydrochloride through Skin using Modulated Iontophoresis and Microneedles, J. Drug Target., 21, 354, 10.3109/1061186X.2012.757768

Liu, 2012, The Development and Characteristics of Novel Microneedle Arrays Fabricated from Hyaluronic Acid, and their Application in the Transdermal Delivery of Insulin, J. Control. Release, 161, 933, 10.1016/j.jconrel.2012.05.030

Prausnitz, 2004, Microneedles for Transdermal Drug Delivery, Adv. Drug Deliv. Rev., 56, 581, 10.1016/j.addr.2003.10.023

Ita, 2015, Transdermal Delivery of Drugs with Microneedles—Potential and Challenges, Pharmaceutics, 7, 90, 10.3390/pharmaceutics7030090

Donnelly, R.F., and Singh, T.R.R. (2015). Novel Delivery Systems for Transdermal and Intradermal Drug Delivery, Wiley.