Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Blood Advances - Tập 3 Số 5 - Trang 729-733 - 2019
Guojie Wu1,2, Blake A. Mazzitelli1,2, Adam J. Quek1,2, Matthew J. Veldman1,2, Paul J. Conroy1,2, Tom T. Caradoc-Davies1,3,2, Lisa M. Ooms1,2, Kellie L. Tuck4, Jonathan G. Schoenecker5, James C. Whisstock1,2,6, Ruby H. P. Law1,2
1ARC Centre of Excellence in Advanced Molecular Imaging, and
2Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia
3Australian Synchrotron, Clayton, Australia
4School of Chemistry, Monash University, Melbourne, Australia
5Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN; and
6South East University–Monash Joint Institute, Institute of Life Sciences, Southeast University, Nanjing, China

Tóm tắt

Key PointsTXA is an active-site inhibitor of uPA. TXA attenuates MDA-MB-231 BAG cell migration and inhibits endogenous uPA activity.

Từ khóa


Tài liệu tham khảo

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