Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis
Tóm tắt
Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve interactions among several physiological systems, e.g. skin, lung, mucosae, and the immune system. It was the aim of this study to compare the effects of age on total and specific IgE in patients with atopic dermatitis (AD), allergic rhinitis or asthma, and insect allergy, respectively. The study population consisted of 559 individuals (male: 229 and female: 330). Total and allergen specific IgE was measured in every individual. From the whole study population, 113 patients suffered from atopic dermatitis (AD), 132 had allergic rhinitis or asthma, and 314 were tested because of insect allergy. Total and specific serum IgE was significantly decreased as a function of age in patients with allergic rhinitis and asthma and with insect allergy. In contrast, no significant decrease of total and specific serum IgE in old individuals with AD was observed. Additionally, in the group of patients with a total IgE < 300 kU/l a reduction of total serum IgE was significantly correlated with age. In contrast, patients with IgE levels > 300 kU/l showed no correlation with age. Immunosenescence does not affect increased IgE levels in atopic patients with AD and/or high serum IgE levels indicating that in these subgroups of patients the atopic propensity remains into advanced age. One may hypothesize that either onset of allergic sensitization during life or the kind of atopic disease influences the correlation between age and IgE synthesis.
Tài liệu tham khảo
Hanneuse Y, Delespesse G, Hudson D, de Halleux F, Jacques JM: Influence of ageing on IgE-mediated reactions in allergic patients. Clin Allergy. 1978, 8: 165-174.
Barbee RA, Brown WG, Kaltenborn W, Halonen M: Allergen skin-test reactivity in a community population sample: correlation with age, histamine skin reactions and total serum immunoglobulin E. J Allergy Clin Immunol. 1981, 68: 15-19.
Barbee RA, Halonen M, Lebowitz M, Burrows B: Distribution of IgE in a community population sample: correlations with age, sex, and allergen skin test reactivity. J Allergy Clin Immunol. 1981, 68: 106-111.
Barbee RA, Halonen M, Kaltenborn W, Lebowitz M, Burrows B: A longitudinal study of serum IgE in a community cohort: correlations with age, sex, smoking, and atopic status. J Allergy Clin Immunol. 1987, 79: 919-927. 10.1016/0091-6749(87)90241-7.
Barbee RA, Kaltenborn W, Lebowitz MD, Burrows B: Longitudinal changes in allergen skin test reactivity in a community population sample. J Allergy Clin Immunol. 1987, 79: 16-24. 10.1016/0091-6749(87)90241-7.
Freidhoff LR, Meyers DA, Bias WB, Chase GA, Hussain R, Marsh DG: A genetic-epidemiologic study of human immune responsiveness to allergens in an industrial population: I. Epidemiology of reported allergy and skin-test positivity. Am J Med Genet. 1981, 9: 323-340.
Freidhoff LR, Meyers DA, Marsh DG: A genetic-epidemiologic study of human immune responsiveness to allergens in an industrial population. II. The associations among skin sensitivity, total serum IgE, age, sex, and the reporting of allergies in a stratified random sample. J Allergy Clin Immunol. 1984, 73: 490-499. 10.1016/0091-6749(84)90360-9.
Pawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C, Franceschi C, Fulop T, Gupta S, Mariani E, Mocchegiani E, Solana R: T cells and aging, January 2002 update. Front Biosci. 2002, 7: d1056-183.
Hannet I, Erkeller-Yuksel F, Lydyard P, Deneys V, Bruyere MD: Developmental and maturational changes in human blood lymphocyte subpopulations. Immunol Today. 1992, 13: 215-218. 10.1016/0167-5699(92)90157-3.
Gabriel H, Schmitt B, Kindermann W: Age-related increase of CD45RO+ lymphocytes in physically active adults. Eur J Immunol. 1993, 23: 2704-2706.
Flurkey K, Stadecker M, Miller RA: Memory lymphocyte-T hyporesponsiveness to non-cognate stimuli - a key factor in age-related immunodeficiency. Eur J Immunol. 1992, 22: 931-935.
Shearer GM: Th1/Th2 changes in aging. Mech Ageing Dev. 1997, 94: 1-5. 10.1016/S0047-6374(96)01849-0.
Klinman NR, Kline GH: The B-cell biology of aging. Immunol Rev. 1997, 160: 103-114.
LeMaoult J, Szabo P, Weksler ME: Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev. 1997, 160: 115-126.
Di Lorenzo G, Pacor ML, Esposito Pellitteri M, Listi F, Colombo A, Candore G, Mansueto P, Lo Bianco C, Ditta V, Battista Rini G, Caruso C: A study of age-related IgE pathophysiological changes. Mech Ageing Dev. 2003, 124: 445-448. 10.1016/S0047-6374(03)00020-4.
Kendall M, Gibbons JD: Rank Correlation Methods. 1990, London, Edward Arnold, 220-5
Jackola DR, Pierson-Mullany LK, Daniels LR, Corazalla E, Rosenberg A, Blumenthal MN: Robustness into advanced age of atopy-specific mechanisms in atopy-prone families. J Gerontol A Biol Sci Med Sci. 2003, 58: 99-107.
Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, van Hage-Hamsten M, Wuthrich B: A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 2001, 56: 813-824. 10.1034/j.1398-9995.2001.t01-1-00001.x.