Total Synthesis of Indole and Dihydroindole Alkaloids. XV. Further Chemistry of Vindoline

Helvetica Chimica Acta - Tập 61 Số 5 - Trang 1554-1564 - 1978
James P. Kutney1, Ursula Bünzli-Trepp1, Toshio Honda1, Junki Katsube1, Brian R. Worth1
1Department of Chemistry , University of British Columbia , 2075 Wesbrook Place, Vancouver , Canada , V6T 1W5

Tóm tắt

AbstractThe general reactivity of various sites in the vindoline series has been investigated. The facility of electrophilic substitution at C(15) and the effect of steric crowding on reactions at C(4) are discussed. At the basic nitrogen sites, oxidations with mercuric acetate and potassium permanganate are also discussed.

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