Thyroid-Associated Orbitopathy and Biomarkers: Where We Are and What We Can Hope for the Future

Disease Markers - Tập 2018 - Trang 1-9 - 2018
Natacha Turck1, Simone Eperon2, Maria De Los Angeles Gracia1, A. Obéric2, M Hamédani2
1Optics Group, Department of Human Protein Sciences, University Medical Center, Geneva, Switzerland
2Department of Ophthalmology, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, Switzerland

Tóm tắt

Background. Thyroid-associated orbitopathy (TAO) is the most common autoimmune disease of the orbit. It occurs more often in patients presenting with hyperthyroidism, characteristic of Graves’ disease, but may be associated with hypothyroidism or euthyroidism. The diagnosis of TAO is based on clinical orbital features, radiological criteria, and the potential association with thyroid disease. To date, there is no specific marker of the orbital disease, making the early diagnosis difficult, especially if the orbital involvement precedes the thyroid dysfunction.Summary. The goal of this review is to present the disease and combine the available data in the literature concerning investigation of TAO biomarkers.Conclusions. Despite the progress done in the understanding of TAO disease, some important pieces are still missing. Typically, for the future, major efforts have to be done in the discovery of new biomarkers, validation of the suspected candidates on multicenter cohorts with standardized methodologies, and establishment of their clinical performances on the specific clinical application fields in order to improve not only the management of the TAO patients but also the therapeutic options and follow-up.

Từ khóa


Tài liệu tham khảo

10.1590/s1679-45082016rc3744

10.1136/bjo.87.3.370

10.6061/clinics/2012(11)18

10.1590/S0004-27492006000300029

10.1097/01.IOP.0000132179.74910.79

10.1590/S0004-27492011000500015

10.1016/S0039-6257(99)00101-0

10.1136/bjo.71.1.32

10.3389/fendo.2017.00184

10.1097/MAJ.0b013e3182582330

10.5603/EP.2016.0061

10.1007/s40618-014-0171-9

1945, Clinical Science, 5, 177

1957, Metabolism, 6, 36

10.1001/archophthalmol.2011.29

10.4103/0301-4738.94048

2011, Maedica, 6, 146

2013, Revue Medicale Suisse, 9, 66, 10.53738/REVMED.2013.9.368.0066

10.1056/NEJMra0905750

10.1089/thy.2013.0240

10.1007/BF03350193

10.1530/EJE-07-0666

10.1016/j.ejim.2011.02.006

10.1136/bjo.73.8.639

10.1016/0002-9394(77)90140-4

10.1097/01.iop.0000235499.34867.85

10.1530/eje.1.02230

10.1210/jc.2013-3207

10.1016/j.beem.2011.11.005

10.1097/IOP.0000000000000037

10.1056/NEJMoa1614949

10.1167/iovs.14-14002

10.1038/nrendo.2014.226

10.1210/endo-119-2-940

10.1080/14728222.2017.1288215

10.1096/fj.13-231381

10.3389/fendo.2016.00167

10.1210/jc.2016-1315

10.1136/bjophthalmol-2015-306634

10.1155/2008/895901

10.1136/bjophthalmol-2015-307399

10.1089/thy.1998.8.429

10.1016/j.exer.2012.11.014

10.1167/iovs.10-6907

10.1067/mcp.2001.113989

2010, Pediatric Endocrinology Reviews, 7, 198

10.1055/s-0033-1363193

10.1007/s12519-014-0476-y

10.1046/j.1365-2265.2000.00959.x

10.1111/j.1365-2265.2008.03192.x

10.1210/jc.2009-2470

10.1210/edrv-14-6-747

10.1016/S0002-9394(14)70276-4

10.1089/thy.2000.10.1093

10.1507/endocrj.52.525

10.1210/jcem-29-2-231

10.1111/j.1365-2265.1995.tb02671.x

10.1507/endocrj.50.595

10.1111/j.1365-2265.2004.02143.x

10.1111/j.1365-2265.2004.02033.x

10.1038/jhg.2016.135

10.1167/iovs.13-13704

10.1111/cen.12778

10.1007/s40618-015-0322-7

10.1371/journal.pone.0064277

10.1507/endocrj.EJ14-0246

2012, Endokrynologia Polska, 63, 92

10.3892/etm.2015.2180

10.4149/endo_2013_02_57

2007, Endokrynologia Polska, 58, 487

10.1155/2017/1297658

10.1111/cen.12392

10.1371/journal.pone.0056533

10.1016/j.ejim.2008.12.005

2004, Archivum Immunologiae et Therapiae Experimentalis, 52, 369

10.2174/138920211798120844

10.1007/s00417-014-2580-z

1983, Clinical and Investigative Medicine, 6, 181

10.20452/pamw.3505

2013, Neuro Endocrinology Letters, 34, 241

10.1111/j.1365-2265.2004.02044.x

10.1038/eye.2008.310

10.1089/thy.2014.0153

10.1136/jclinpath-2012-200719

10.1210/jc.2012-1020

10.1210/jc.2011-2697

10.1159/000367968

10.1167/iovs.08-2443

10.1167/iovs.15-17001

10.1167/iovs.14-14873

10.1155/2015/340934

10.1080/08820530701745256

10.1007/s12020-012-9840-7

10.1167/iovs.15-16699

10.1210/jc.2015-2976

Thông tin
Thông tin xuất bản

Disease Markers

Tập 2018

1-9

Thông tin tác giả