Three‐dimensional whole‐heart T<sub>2</sub> mapping at 3T

Magnetic Resonance in Medicine - Tập 74 Số 3 - Trang 803-816 - 2015
Haiyan Ding1,2, L. Fernandez-de-Manuel3,2, Michael Schär4,5, Karl H. Schuleri6, Henry R. Halperin6, Le He1, Muz Zviman6, Roy Beinart7,8, Daniel A. Herzka2
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China
2Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
3Biomedical Image Technologies Laboratory ETSI Telecomunicación, Universidad Politécnica de Madrid, and CIBER‐BBN Madrid Spain
4Philips Healthcare, Cleveland, Ohio, USA
5Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
6Department of Medicine - Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
7Department of Medicine, Cardiology; Johns Hopkins School of Medicine; Baltimore Maryland USA
8Heart Institute, Sheba Medical Center, Tel Aviv University, Ramat Gan, Israel

Tóm tắt

PurposeDetecting variations in myocardial water content with T2 mapping is superior to conventional T2‐weighted MRI since quantification enables direct observation of complicated pathology. Most commonly used T2 mapping techniques are limited in achievable spatial and/or temporal resolution, both of which reduce accuracy due to partial‐volume averaging and misregistration between images. The goal of this study was to validate a novel free breathing T2 mapping sequence that overcomes these limitations.MethodsThe proposed technique was made insensitive to heart rate variability through the use of a saturation prepulse to reset magnetization every heartbeat. Respiratory navigator‐gated, differentially T2‐weighted volumes were interleaved per heartbeat, guaranteeing registered images and robust voxel‐by‐voxel T2 maps. Free breathing acquisitions removed limits on spatial resolution and allowed short diastolic windows. Accuracy was quantified with simulations and phantoms.ResultsHomogeneous three‐dimensional (3D) T2 maps were obtained from normal human subjects and swine. Normal human and swine left ventricular T2 values were 42.3 ± 4.0 and 43.5 ± 4.3 ms, respectively. The T2 value for edematous myocardium obtained from a swine model of acute myocardial infarction was 59.1 ± 7.1 ms.ConclusionFree‐breathing accurate 3D T2 mapping is feasible and may be applicable in myocardial assessment in lieu of current clinical black blood, T2‐weighted techniques. Magn Reson Med 74:803–816, 2015. © 2014 Wiley Periodicals, Inc.

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Magnetic Resonance in Medicine

Tập 74 Số 3

803-816

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